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- W3183168921 abstract "Abstract Protein-protein interactions (PPIs) are important in understanding numerous aspects of protein function. Here, the recently developed all-vs-all sequencing (AVA-Seq) approach to determine protein-protein interactions was tested on a gold-standard human protein interaction set (hsPRS-v2). Initially, these data were interpreted strictly from a binary PPI perspective to compare AVA-Seq to other binary PPI methods tested on the same hsPRS-v2. AVA-Seq recovered 20 of 47 (43%) binary PPIs from this reference set comparing favorably with other methods. The same experimental data allowed for the determination of >500 known and novel PPIs including interactions between wildtype fragments of tumor protein p53 and minichromosomal maintenance complex proteins 2, and 5 (MCM2 and MCM5) that could be of interest in human disease. Additional results gave a better understanding of why interactions might be missed using AVA-Seq and aide future PPI experimental design for maximum recovery of information." @default.
- W3183168921 created "2021-08-02" @default.
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- W3183168921 date "2021-07-29" @default.
- W3183168921 modified "2023-10-16" @default.
- W3183168921 title "High-resolution protein fragment interactions using AVA-Seq on a human reference set" @default.
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- W3183168921 doi "https://doi.org/10.1101/2021.07.28.454266" @default.
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