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- W3183169674 abstract "A reinvestigation of the linalool synthase from Chryseobacterium polytrichastri uncovered its diterpene synthase activity, yielding polytrichastrene A and polytrichastrol A with new skeletons, besides known wanju-2,5-diene and thunbergol. The enzyme mechanism was investigated by isotopic labeling experiments and DFT calculations to explain an unusual ethyl group formation. Rationally designed exchanges of active site residues showed major functional switches, resulting for I66F in the production of five more new compounds, including polytrichastrene B and polytrichastrol B, while A87T, A192V and the double exchange A87T, A192V gave a product shift towards wanju-2,5-diene." @default.
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- W3183169674 date "2021-08-13" @default.
- W3183169674 modified "2023-10-07" @default.
- W3183169674 title "Functional Switch and Ethyl Group Formation in the Bacterial Polytrichastrene Synthase from <i>Chryseobacterium polytrichastri</i>" @default.
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- W3183169674 doi "https://doi.org/10.1002/anie.202109465" @default.
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