FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183189600> ?p ?o ?g. }

• W3183189600 abstract "The colonization of the human gut microbiome begins at birth, and over time, these microbial communities become increasingly complex. Most of what we currently know about the human microbiome, especially in early stages of development, was described using culture-independent sequencing methods that allow us to identify the taxonomic composition of microbial communities using genomic techniques, such as amplicon or shotgun metagenomic sequencing. Each method has distinct tradeoffs, but there has not been a direct comparison of the utility of these methods in stool samples from very young children, which have different features than those of adults. We compared the effects of profiling the human infant gut microbiome with 16S rRNA amplicon vs. shotgun metagenomic sequencing techniques in 338 fecal samples; younger than 15, 15–30, and older than 30 months of age. We demonstrate that observed changes in alpha-diversity and beta-diversity with age occur to similar extents using both profiling methods. We also show that 16S rRNA profiling identified a larger number of genera and we find several genera that are missed or underrepresented by each profiling method. We present the link between alpha diversity and shotgun metagenomic sequencing depth for children of different ages. These findings provide a guide for selecting an appropriate method and sequencing depth for the three studied age groups." @default.
• W3183189600 created "2021-08-02" @default.
• W3183189600 creator A5001700176 @default.
• W3183189600 creator A5003099948 @default.
• W3183189600 creator A5003679461 @default.
• W3183189600 creator A5008540004 @default.
• W3183189600 creator A5010741021 @default.
• W3183189600 creator A5015093036 @default.
• W3183189600 creator A5015480892 @default.
• W3183189600 creator A5015660912 @default.
• W3183189600 creator A5019497292 @default.
• W3183189600 creator A5032607965 @default.
• W3183189600 creator A5033437526 @default.
• W3183189600 creator A5034510694 @default.
• W3183189600 creator A5034557867 @default.
• W3183189600 creator A5035160894 @default.
• W3183189600 creator A5037628555 @default.
• W3183189600 creator A5042340545 @default.
• W3183189600 creator A5050617224 @default.
• W3183189600 creator A5058854742 @default.
• W3183189600 creator A5059589604 @default.
• W3183189600 creator A5060071396 @default.
• W3183189600 creator A5060319609 @default.
• W3183189600 creator A5061061525 @default.
• W3183189600 creator A5062656684 @default.
• W3183189600 creator A5072577224 @default.
• W3183189600 creator A5074562026 @default.
• W3183189600 creator A5075079684 @default.
• W3183189600 creator A5076287559 @default.
• W3183189600 creator A5077061085 @default.
• W3183189600 creator A5081286376 @default.
• W3183189600 creator A5091570506 @default.
• W3183189600 date "2021-07-15" @default.
• W3183189600 modified "2023-10-10" @default.
• W3183189600 title "Comparative Analysis of 16S rRNA Gene and Metagenome Sequencing in Pediatric Gut Microbiomes" @default.
• W3183189600 cites W1512978277 @default.
• W3183189600 cites W1952026831 @default.
• W3183189600 cites W1961864475 @default.
• W3183189600 cites W1979966476 @default.
• W3183189600 cites W1988981743 @default.
• W3183189600 cites W1995875735 @default.
• W3183189600 cites W2027946048 @default.
• W3183189600 cites W2031611770 @default.
• W3183189600 cites W2034285706 @default.
• W3183189600 cites W2036897871 @default.
• W3183189600 cites W2050853710 @default.
• W3183189600 cites W2052969143 @default.
• W3183189600 cites W2054385769 @default.
• W3183189600 cites W2084443943 @default.
• W3183189600 cites W2097944779 @default.
• W3183189600 cites W2115701239 @default.
• W3183189600 cites W2116846792 @default.
• W3183189600 cites W2124967403 @default.
• W3183189600 cites W2131026689 @default.
• W3183189600 cites W2132366863 @default.
• W3183189600 cites W2132929849 @default.
• W3183189600 cites W2141637710 @default.
• W3183189600 cites W2144464830 @default.
• W3183189600 cites W2147618390 @default.
• W3183189600 cites W2154003902 @default.
• W3183189600 cites W2155806125 @default.
• W3183189600 cites W2162088497 @default.
• W3183189600 cites W2165182881 @default.
• W3183189600 cites W2207819727 @default.
• W3183189600 cites W2321945161 @default.
• W3183189600 cites W2333481637 @default.
• W3183189600 cites W2343597029 @default.
• W3183189600 cites W2397246897 @default.
• W3183189600 cites W2401404581 @default.
• W3183189600 cites W2424275162 @default.
• W3183189600 cites W2465554544 @default.
• W3183189600 cites W2470154003 @default.
• W3183189600 cites W2486241512 @default.
• W3183189600 cites W2564755845 @default.
• W3183189600 cites W2578149194 @default.
• W3183189600 cites W2592367925 @default.
• W3183189600 cites W2593591803 @default.
• W3183189600 cites W2604308930 @default.
• W3183189600 cites W2762425175 @default.
• W3183189600 cites W2770040643 @default.
• W3183189600 cites W2787925891 @default.
• W3183189600 cites W2789806379 @default.
• W3183189600 cites W2792665386 @default.
• W3183189600 cites W2792871760 @default.
• W3183189600 cites W2798082096 @default.
• W3183189600 cites W2800231416 @default.
• W3183189600 cites W2806408903 @default.
• W3183189600 cites W2807194798 @default.
• W3183189600 cites W2895153150 @default.
• W3183189600 cites W2896481903 @default.
• W3183189600 cites W2909919296 @default.
• W3183189600 cites W2915511928 @default.
• W3183189600 cites W2918137196 @default.
• W3183189600 cites W2927961455 @default.
• W3183189600 cites W2945250978 @default.
• W3183189600 cites W2947129834 @default.
• W3183189600 cites W2949098970 @default.
• W3183189600 cites W2951076599 @default.
• W3183189600 cites W2952152744 @default.
• W3183189600 cites W2963276645 @default.

• next