FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183201975> ?p ?o ?g. }

• W3183201975 abstract "Abstract Background Emergence of Plasmodium falciparum resistance to artemisinin and its derivatives poses a threat to the global effort to control malaria. The emergence of anti-malarial resistance has become a great public health challenge and continues to be a leading threat to ongoing malaria control efforts. The aim of this review was to synthesize available evidence on the efficacy of dihydroartemisinin-piperaquine (DHA-PQ) compared to artemether-lumefantrine (AL) for the treatment of uncomplicated falciparum malaria among children in Africa. Methods A systematic literature search was done to identify relevant articles from online databases PubMed/ MEDLINE, Embase, and Cochrane Central Register of Controlled Trials’ database (CENTRAL) for retrieving randomized control trials comparing efficacy of DHA-PQ and AL for treatment of uncomplicated falciparum malaria in African children. The search was performed from August 2020 to April 2021. Using Rev-Man software (V5.4.1), R-studio and Comprehensive Meta-analysis software version 3, the extracted data from eligible studies were pooled as risk ratio (RR) with 95% confidence interval (CI). Results In this review, 25 studies which involved a total of 13,198 participants were included. PCR-unadjusted treatment failure in children aged between 6 months and 15 years was significantly lower in the DHA-PQ treatment arm on day 28 than that of AL (RR 0.14, 95% CI 0.08–0.26; participants = 1302; studies = 4; I 2 = 0%, high quality of evidence). Consistently, the PCR-adjusted treatment failure was significantly lower with DHA-PQ treatment group on day 28 (RR 0.45, 95% CI 0.29–0.68; participants = 8508; studies = 16; I 2 = 51%, high quality of evidence) and on day 42 (RR 0.60, 95% CI 0.47–0.78; participants = 5959; studies = 17; I 2 = 0%, high quality of evidence). However, the efficacy was ≥ 95% in both treatment groups on day 28. Conclusion From this review, it can be concluded that DHA-PQ reduces new infection and recrudescence on days 28 and 42 more than AL. This may trigger DHA-PQ to become a first-line treatment option." @default.
• W3183201975 created "2021-08-02" @default.
• W3183201975 creator A5022301113 @default.
• W3183201975 creator A5042828277 @default.
• W3183201975 creator A5082312020 @default.
• W3183201975 date "2021-08-12" @default.
• W3183201975 modified "2023-10-12" @default.
• W3183201975 title "Efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria among children in Africa: a systematic review and meta-analysis of randomized control trials" @default.
• W3183201975 cites W1275343739 @default.
• W3183201975 cites W1483203554 @default.
• W3183201975 cites W1977852231 @default.
• W3183201975 cites W2039639971 @default.
• W3183201975 cites W2056604901 @default.
• W3183201975 cites W2067656239 @default.
• W3183201975 cites W2077188081 @default.
• W3183201975 cites W2085452046 @default.
• W3183201975 cites W2090132603 @default.
• W3183201975 cites W2104657845 @default.
• W3183201975 cites W2107461435 @default.
• W3183201975 cites W2112222406 @default.
• W3183201975 cites W2118868447 @default.
• W3183201975 cites W2119156545 @default.
• W3183201975 cites W2122534122 @default.
• W3183201975 cites W2122967261 @default.
• W3183201975 cites W2129428401 @default.
• W3183201975 cites W2135970036 @default.
• W3183201975 cites W2137432389 @default.
• W3183201975 cites W2139430647 @default.
• W3183201975 cites W2144874346 @default.
• W3183201975 cites W2147136758 @default.
• W3183201975 cites W2150644831 @default.
• W3183201975 cites W2151344802 @default.
• W3183201975 cites W2157656397 @default.
• W3183201975 cites W2159536724 @default.
• W3183201975 cites W2161311583 @default.
• W3183201975 cites W2171102256 @default.
• W3183201975 cites W2229864756 @default.
• W3183201975 cites W2412881656 @default.
• W3183201975 cites W2467259677 @default.
• W3183201975 cites W2585849544 @default.
• W3183201975 cites W2604706316 @default.
• W3183201975 cites W2767127869 @default.
• W3183201975 cites W2802043998 @default.
• W3183201975 cites W2809951886 @default.
• W3183201975 cites W2826739133 @default.
• W3183201975 cites W2895245324 @default.
• W3183201975 cites W2922704184 @default.
• W3183201975 cites W2960101348 @default.
• W3183201975 cites W2966856643 @default.
• W3183201975 cites W2974747689 @default.
• W3183201975 cites W2995187875 @default.
• W3183201975 cites W3031413726 @default.
• W3183201975 cites W3049606700 @default.
• W3183201975 cites W3084440238 @default.
• W3183201975 cites W3118615836 @default.
• W3183201975 cites W3121951570 @default.
• W3183201975 cites W3124145179 @default.
• W3183201975 cites W3125384312 @default.
• W3183201975 cites W3143367749 @default.
• W3183201975 doi "https://doi.org/10.1186/s12936-021-03873-1" @default.
• W3183201975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8359548" @default.
• W3183201975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34384431" @default.
• W3183201975 hasPublicationYear "2021" @default.
• W3183201975 type Work @default.
• W3183201975 sameAs 3183201975 @default.
• W3183201975 citedByCount "6" @default.
• W3183201975 countsByYear W31832019752021 @default.
• W3183201975 countsByYear W31832019752022 @default.
• W3183201975 countsByYear W31832019752023 @default.
• W3183201975 crossrefType "journal-article" @default.
• W3183201975 hasAuthorship W3183201975A5022301113 @default.
• W3183201975 hasAuthorship W3183201975A5042828277 @default.
• W3183201975 hasAuthorship W3183201975A5082312020 @default.
• W3183201975 hasBestOaLocation W31832019751 @default.
• W3183201975 hasConcept C126322002 @default.
• W3183201975 hasConcept C142724271 @default.
• W3183201975 hasConcept C168563851 @default.
• W3183201975 hasConcept C185032368 @default.
• W3183201975 hasConcept C203014093 @default.
• W3183201975 hasConcept C2776120307 @default.
• W3183201975 hasConcept C2778048844 @default.
• W3183201975 hasConcept C2778059366 @default.
• W3183201975 hasConcept C2778118209 @default.
• W3183201975 hasConcept C2778371730 @default.
• W3183201975 hasConcept C2778629330 @default.
• W3183201975 hasConcept C2781160685 @default.
• W3183201975 hasConcept C44249647 @default.
• W3183201975 hasConcept C71924100 @default.
• W3183201975 hasConcept C82789193 @default.
• W3183201975 hasConcept C95190672 @default.
• W3183201975 hasConceptScore W3183201975C126322002 @default.
• W3183201975 hasConceptScore W3183201975C142724271 @default.
• W3183201975 hasConceptScore W3183201975C168563851 @default.
• W3183201975 hasConceptScore W3183201975C185032368 @default.
• W3183201975 hasConceptScore W3183201975C203014093 @default.
• W3183201975 hasConceptScore W3183201975C2776120307 @default.
• W3183201975 hasConceptScore W3183201975C2778048844 @default.
• W3183201975 hasConceptScore W3183201975C2778059366 @default.
• W3183201975 hasConceptScore W3183201975C2778118209 @default.
• W3183201975 hasConceptScore W3183201975C2778371730 @default.

• next