Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183207415> ?p ?o ?g. }
- W3183207415 endingPage "243" @default.
- W3183207415 startingPage "235" @default.
- W3183207415 abstract "Atopic diseases, such as atopic dermatitis (AD), allergic asthma (AA), and allergic rhinitis (AR), are increasingly becoming a worldwide issue. This atopic triad originates at an early age and on a multifactorial basis, causing significant discomfort to susceptible individuals. The global case number is now reaching new highs, so exploring immune system regulation and its components is becoming critical. One cytokine, interleukin-32 (IL-32), is involved in inflammation and regulation of the immune system. It has nine isoforms that show varying degrees of expression, both intracellularly and extracellularly. IL-32 is secreted by immune cells, such as monocytes, macrophages, natural killer cells, and T cells, and by nonimmune cells, including fibroblasts, keratinocytes, and endothelial cells. Its production is regulated and augmented by microorganisms, mitogens, and other cytokines. Early studies demonstrated that IL-32 was an immune regulator that functioned to protect against inflammatory diseases, including AD, AA, and AR, and proposed a proinflammatory role for IL-32 in immune regulation and symptom exacerbation. However, several later reports suggested that IL-32 is downregulated in inflammatory diseases and exerts an anti-inflammatory effect. This review article focuses on recent findings regarding the detrimental and protective roles of IL-32 in development and management of inflammatory diseases. The exact role of IL-32 in AD, AA, and AR still remains to be elucidated. Future research should explore new avenues of IL-32 functionality in human inflammatory diseases." @default.
- W3183207415 created "2021-08-02" @default.
- W3183207415 creator A5023986279 @default.
- W3183207415 creator A5070918864 @default.
- W3183207415 date "2021-07-01" @default.
- W3183207415 modified "2023-10-16" @default.
- W3183207415 title "Interleukin-32 in Pathogenesis of Atopic Diseases: Proinflammatory or Anti-Inflammatory Role?" @default.
- W3183207415 cites W1527957830 @default.
- W3183207415 cites W1536028944 @default.
- W3183207415 cites W1548087739 @default.
- W3183207415 cites W1948783774 @default.
- W3183207415 cites W1964539025 @default.
- W3183207415 cites W1967686662 @default.
- W3183207415 cites W1969884127 @default.
- W3183207415 cites W1973394808 @default.
- W3183207415 cites W1973668473 @default.
- W3183207415 cites W1983530785 @default.
- W3183207415 cites W1986204042 @default.
- W3183207415 cites W1986600983 @default.
- W3183207415 cites W1993815621 @default.
- W3183207415 cites W1994184600 @default.
- W3183207415 cites W1995335649 @default.
- W3183207415 cites W1996220295 @default.
- W3183207415 cites W1996223831 @default.
- W3183207415 cites W1996398325 @default.
- W3183207415 cites W1998442642 @default.
- W3183207415 cites W2002123566 @default.
- W3183207415 cites W2010587928 @default.
- W3183207415 cites W2012755706 @default.
- W3183207415 cites W2020206647 @default.
- W3183207415 cites W2020688071 @default.
- W3183207415 cites W2024428337 @default.
- W3183207415 cites W2024773806 @default.
- W3183207415 cites W2030189317 @default.
- W3183207415 cites W2038008688 @default.
- W3183207415 cites W2053321569 @default.
- W3183207415 cites W2061163648 @default.
- W3183207415 cites W2062428707 @default.
- W3183207415 cites W2063850268 @default.
- W3183207415 cites W2082737488 @default.
- W3183207415 cites W2083874662 @default.
- W3183207415 cites W2083909329 @default.
- W3183207415 cites W2085429107 @default.
- W3183207415 cites W2085508489 @default.
- W3183207415 cites W2097512250 @default.
- W3183207415 cites W2098108973 @default.
- W3183207415 cites W2112663355 @default.
- W3183207415 cites W2113810254 @default.
- W3183207415 cites W2113831203 @default.
- W3183207415 cites W2118750312 @default.
- W3183207415 cites W2119885078 @default.
- W3183207415 cites W2127092918 @default.
- W3183207415 cites W2127203245 @default.
- W3183207415 cites W2136559637 @default.
- W3183207415 cites W2138148311 @default.
- W3183207415 cites W2140577474 @default.
- W3183207415 cites W2142289238 @default.
- W3183207415 cites W2149912273 @default.
- W3183207415 cites W2155509911 @default.
- W3183207415 cites W2169970560 @default.
- W3183207415 cites W2230991025 @default.
- W3183207415 cites W2304609579 @default.
- W3183207415 cites W2333549840 @default.
- W3183207415 cites W2339109475 @default.
- W3183207415 cites W2341079862 @default.
- W3183207415 cites W2399472917 @default.
- W3183207415 cites W2517700447 @default.
- W3183207415 cites W2518680640 @default.
- W3183207415 cites W2544435890 @default.
- W3183207415 cites W2592503261 @default.
- W3183207415 cites W2605908163 @default.
- W3183207415 cites W2608201651 @default.
- W3183207415 cites W2623554746 @default.
- W3183207415 cites W2734299438 @default.
- W3183207415 cites W2735412263 @default.
- W3183207415 cites W2762681938 @default.
- W3183207415 cites W2772904315 @default.
- W3183207415 cites W2784010902 @default.
- W3183207415 cites W2790372871 @default.
- W3183207415 cites W2805210613 @default.
- W3183207415 cites W2807747724 @default.
- W3183207415 cites W2809022050 @default.
- W3183207415 cites W2809566874 @default.
- W3183207415 cites W2862189625 @default.
- W3183207415 cites W2887679679 @default.
- W3183207415 cites W2893246444 @default.
- W3183207415 cites W2902671631 @default.
- W3183207415 cites W2916610774 @default.
- W3183207415 cites W2943156525 @default.
- W3183207415 cites W2951931980 @default.
- W3183207415 cites W2965129239 @default.
- W3183207415 cites W2970292077 @default.
- W3183207415 cites W2971960535 @default.
- W3183207415 cites W2980226139 @default.
- W3183207415 cites W2981325831 @default.
- W3183207415 cites W2984115711 @default.
- W3183207415 cites W3000707875 @default.
- W3183207415 cites W3010681245 @default.