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- W3183229223 startingPage "7737" @default.
- W3183229223 abstract "The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological processes, including parturition, lactation, cell growth, wound healing, and social behavior. More recently, increasing evidence has established the effects of oxytocin on food intake, energy expenditure, and peripheral metabolism. In this review, we provide a comprehensive description of the central oxytocinergic system in which oxytocin acts to shape eating behavior and metabolism. Next, we discuss the peripheral beneficial effects oxytocin exerts on key metabolic organs, including suppression of visceral adipose tissue inflammation, skeletal muscle regeneration, and bone tissue mineralization. A brief summary of oxytocin actions learned from animal models is presented, showing that weight loss induced by chronic oxytocin treatment is related not only to its anorexigenic effects, but also to the resulting increase in energy expenditure and lipolysis. Following an in-depth discussion on the technical challenges related to endogenous oxytocin measurements in humans, we synthesize data related to the association between endogenous oxytocin levels, weight status, metabolic syndrome, and bone health. We then review clinical trials showing that in humans, acute oxytocin administration reduces food intake, attenuates fMRI activation of food motivation brain areas, and increases activation of self-control brain regions. Further strengthening the role of oxytocin in appetite regulation, we review conditions of hypothalamic insult and certain genetic pathologies associated with oxytocin depletion that present with hyperphagia, extreme weight gain, and poor metabolic profile. Intranasal oxytocin is currently being evaluated in human clinical trials to learn whether oxytocin-based therapeutics can be used to treat obesity and its associated sequela. At the end of this review, we address the fundamental challenges that remain in translating this line of research to clinical care." @default.
- W3183229223 created "2021-08-02" @default.
- W3183229223 creator A5006543624 @default.
- W3183229223 creator A5088073213 @default.
- W3183229223 date "2021-07-20" @default.
- W3183229223 modified "2023-10-06" @default.
- W3183229223 title "The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans" @default.
- W3183229223 cites W122399824 @default.
- W3183229223 cites W1502693045 @default.
- W3183229223 cites W1525279530 @default.
- W3183229223 cites W1532235063 @default.
- W3183229223 cites W1561443084 @default.
- W3183229223 cites W1602255891 @default.
- W3183229223 cites W1627886265 @default.
- W3183229223 cites W1826369257 @default.
- W3183229223 cites W1861892758 @default.
- W3183229223 cites W1922423641 @default.
- W3183229223 cites W1964559979 @default.
- W3183229223 cites W1968793849 @default.
- W3183229223 cites W1969420213 @default.
- W3183229223 cites W1969917245 @default.
- W3183229223 cites W1971716149 @default.
- W3183229223 cites W1972127276 @default.
- W3183229223 cites W1974011030 @default.
- W3183229223 cites W1975008822 @default.
- W3183229223 cites W1976814389 @default.
- W3183229223 cites W1977409318 @default.
- W3183229223 cites W1978044599 @default.
- W3183229223 cites W1978165201 @default.
- W3183229223 cites W1978486525 @default.
- W3183229223 cites W1981100482 @default.
- W3183229223 cites W1982747041 @default.
- W3183229223 cites W1984642682 @default.
- W3183229223 cites W1984838611 @default.
- W3183229223 cites W1986792783 @default.
- W3183229223 cites W1989249916 @default.
- W3183229223 cites W1990245349 @default.
- W3183229223 cites W1991442212 @default.
- W3183229223 cites W1991834855 @default.
- W3183229223 cites W1992547598 @default.
- W3183229223 cites W1994025579 @default.
- W3183229223 cites W1995318224 @default.
- W3183229223 cites W1999753672 @default.
- W3183229223 cites W2000182001 @default.
- W3183229223 cites W2000312962 @default.
- W3183229223 cites W2001160654 @default.
- W3183229223 cites W2002422041 @default.
- W3183229223 cites W2008667373 @default.
- W3183229223 cites W2010809763 @default.
- W3183229223 cites W2012771984 @default.
- W3183229223 cites W2013694191 @default.
- W3183229223 cites W2016886211 @default.
- W3183229223 cites W2017290050 @default.
- W3183229223 cites W2018038256 @default.
- W3183229223 cites W2023636464 @default.
- W3183229223 cites W2023780399 @default.
- W3183229223 cites W2027956310 @default.
- W3183229223 cites W2029372047 @default.
- W3183229223 cites W2029619104 @default.
- W3183229223 cites W2032927087 @default.
- W3183229223 cites W2034407748 @default.
- W3183229223 cites W2038970714 @default.
- W3183229223 cites W2040402447 @default.
- W3183229223 cites W2042099974 @default.
- W3183229223 cites W2042213884 @default.
- W3183229223 cites W2042845786 @default.
- W3183229223 cites W2048715566 @default.
- W3183229223 cites W2049356067 @default.
- W3183229223 cites W2050870573 @default.
- W3183229223 cites W2050973673 @default.
- W3183229223 cites W2052624720 @default.
- W3183229223 cites W2055374671 @default.
- W3183229223 cites W2057424192 @default.
- W3183229223 cites W2057702387 @default.
- W3183229223 cites W2058467798 @default.
- W3183229223 cites W2060180675 @default.
- W3183229223 cites W2061257354 @default.
- W3183229223 cites W2062418273 @default.
- W3183229223 cites W2062508009 @default.
- W3183229223 cites W2062546576 @default.
- W3183229223 cites W2062756785 @default.
- W3183229223 cites W2068155003 @default.
- W3183229223 cites W2069300470 @default.
- W3183229223 cites W2069935277 @default.
- W3183229223 cites W2070426190 @default.
- W3183229223 cites W2073175641 @default.
- W3183229223 cites W2076652575 @default.
- W3183229223 cites W2078628715 @default.
- W3183229223 cites W2078944460 @default.
- W3183229223 cites W2080694955 @default.
- W3183229223 cites W2082561815 @default.
- W3183229223 cites W2084234221 @default.
- W3183229223 cites W2084424279 @default.
- W3183229223 cites W2084802447 @default.
- W3183229223 cites W2085708523 @default.
- W3183229223 cites W2086946590 @default.
- W3183229223 cites W2088864173 @default.
- W3183229223 cites W2090036936 @default.