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• W3183242215 endingPage "1920" @default.
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• W3183242215 abstract "Neisseria gonorrhoeae (gonococcus) causes the human sexually transmitted disease gonorrhea. Studying gonococcal pathogenesis and developing new vaccines and therapies to combat the increasing prevalence of multi-antibiotic resistant bacteria has made use of many ex vivo models based on human cells and tissues, and in vivo vertebrate models, for example, rodent, pig and human. The focus of the current study was to examine the utility of the invertebrate greater wax moth Galleria mellonella as an in vivo model of gonococcal infection. We observed that a threshold of ~106 - 107 gonococci/larva was required to kill >50% of larvae (P < 0.05), and increased toxicity correlated with reduced health index scores and pronounced histopathological changes such as increases in the total lesion grade, melanized nodules, hemocyte reaction, and multifocal adipose body degeneration. Larval death was independent of the expression of pilus or Opa protein or LOS sialylation within a single gonococcal species studied, but the model could demonstrate relative toxicity of different isolates. N. meningitidis, N. lacatamica and gonococci all killed larvae equally, but were significantly less toxic (P > 0.05) than Pseudomonas aeruginosa. Larvae primed with nontoxic doses of gonococci were more susceptible to subsequent challenge with homologous and heterologous bacteria, and larval survival was significantly reduced (P < 0.05) in infected larvae after depletion of their hemocytes with clodronate-liposomes. The model was used to test the anti-gonococcal properties of antibiotics and novel antimicrobials. Ceftriaxone (P < 0.05) protected larvae from infection with different gonococcal isolates, but not azithromycin or monocaprin or ligand-coated silver nanoclusters (P > 0.05)." @default.
• W3183242215 created "2021-08-02" @default.
• W3183242215 creator A5033439222 @default.
• W3183242215 creator A5034567657 @default.
• W3183242215 creator A5042133390 @default.
• W3183242215 creator A5049389523 @default.
• W3183242215 creator A5086426638 @default.
• W3183242215 date "2021-07-25" @default.
• W3183242215 modified "2023-10-17" @default.
• W3183242215 title "Establishing an invertebrate <i>Galleria mellonella</i> greater wax moth larval model of <i>Neisseria gonorrhoeae</i> infection" @default.
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• W3183242215 doi "https://doi.org/10.1080/21505594.2021.1950269" @default.
• W3183242215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8312596" @default.
• W3183242215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34304706" @default.
• W3183242215 hasPublicationYear "2021" @default.
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