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- W3183243013 abstract "The first application of 3-alkyl-2-vinylindoles in catalytic asymmetric dearomative cycloadditions was established by chiral phosphoric acid (CPA)-catalyzed (2+3) cycloaddition with azoalkenes, leading to the generation of chiral pyrroloindolines bearing two tetrasubstituted stereogenic centers in good yields (61–96%) and excellent stereoselectivities (all >95:5 dr, 86–99% ee). This reaction has realized the first enantioselective dearomative cycloaddition of 3-alkyl-2-vinylindoles, which brings a new reactivity to this class of vinylindoles and will enrich the chemistry of 3-alkyl-2-vinylindoles. In addition, this approach has provided a useful strategy for the construction of enantioenriched pyrroloindoline skeletons bearing two tetrasubstituted stereogenic centers. More importantly, the bioassay of these chiral pyrroloindolines has revealed that some compounds exhibit strong anti-cancer activity against Hela and MCF-7 cell lines, which will be helpful for discovering anti-cancer drug candidates." @default.
- W3183243013 created "2021-08-02" @default.
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- W3183243013 creator A5091068751 @default.
- W3183243013 date "2021-07-27" @default.
- W3183243013 modified "2023-10-10" @default.
- W3183243013 title "Application of 3-Alkyl-2-vinylindoles in Catalytic Asymmetric Dearomative (2+3) Cycloadditions" @default.
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- W3183243013 doi "https://doi.org/10.1021/acs.joc.1c01105" @default.
- W3183243013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34313431" @default.
- W3183243013 hasPublicationYear "2021" @default.
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