FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183286210> ?p ?o ?g. }

• W3183286210 endingPage "2621" @default.
• W3183286210 startingPage "2606" @default.
• W3183286210 abstract "Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still remains largely unknown. Emerging evidence suggested that some chemotherapeutic drugs played anti-tumor effects by inducing cell pyroptosis. Nevertheless, whether pyroptosis contributes to the DDP-induced anti-tumor effect in TNBC remains unexploited. In the present study, NLRP3/caspase-1/GSDMD pyroptosis pathway was involved in the DDP-induced anti-tumor effect of TNBC in vitro and in vivo, providing evidence that DDP might induce pyroptosis in TNBC. Moreover, DDP activated NLRP3/caspase-1/GSDMD pyroptosis pathway by up-regulating the long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3). Furthermore, knockdown of MEG3 not only partly abolished the activation effect of DDP on NLRP3/caspase-1/GSDMD pathway-mediated pyroptosis, but also reversed the suppression of DDP on tumor growth and metastasis ability in vitro and in vivo, further confirming that MEG3 may partially mediate the pyroptotic signaling upon DDP treatment. Thus, our data uncovered a novel mechanism that DDP induced pyroptosis via activation of MEG3/NLRP3/caspase-1/GSDMD pathway in TNBC to exert anti-tumor effects, which may help to develop new strategies for the therapeutic interventions in TNBC." @default.
• W3183286210 created "2021-08-02" @default.
• W3183286210 creator A5000940922 @default.
• W3183286210 creator A5002203815 @default.
• W3183286210 creator A5021430966 @default.
• W3183286210 creator A5027036708 @default.
• W3183286210 creator A5039566796 @default.
• W3183286210 creator A5046538435 @default.
• W3183286210 creator A5077467339 @default.
• W3183286210 creator A5081525840 @default.
• W3183286210 creator A5082167565 @default.
• W3183286210 date "2021-01-01" @default.
• W3183286210 modified "2023-10-14" @default.
• W3183286210 title "Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer" @default.
• W3183286210 cites W1864325817 @default.
• W3183286210 cites W1965225327 @default.
• W3183286210 cites W2049494585 @default.
• W3183286210 cites W2072860434 @default.
• W3183286210 cites W2089503694 @default.
• W3183286210 cites W2175794645 @default.
• W3183286210 cites W2201316930 @default.
• W3183286210 cites W2461915818 @default.
• W3183286210 cites W2469002912 @default.
• W3183286210 cites W2608687752 @default.
• W3183286210 cites W2761624970 @default.
• W3183286210 cites W2766531047 @default.
• W3183286210 cites W2767981580 @default.
• W3183286210 cites W2768102094 @default.
• W3183286210 cites W2770936091 @default.
• W3183286210 cites W2774335059 @default.
• W3183286210 cites W2784062576 @default.
• W3183286210 cites W2784570320 @default.
• W3183286210 cites W2788640168 @default.
• W3183286210 cites W2789997601 @default.
• W3183286210 cites W2807418950 @default.
• W3183286210 cites W2890037152 @default.
• W3183286210 cites W2897368647 @default.
• W3183286210 cites W2898096959 @default.
• W3183286210 cites W2907424910 @default.
• W3183286210 cites W2911937431 @default.
• W3183286210 cites W2921978320 @default.
• W3183286210 cites W2922122232 @default.
• W3183286210 cites W2926902798 @default.
• W3183286210 cites W2965236776 @default.
• W3183286210 cites W2990249901 @default.
• W3183286210 cites W2990599669 @default.
• W3183286210 cites W3007922183 @default.
• W3183286210 cites W3014055732 @default.
• W3183286210 cites W3018541786 @default.
• W3183286210 cites W3031939267 @default.
• W3183286210 cites W3033191323 @default.
• W3183286210 cites W3034265615 @default.
• W3183286210 doi "https://doi.org/10.7150/ijbs.60292" @default.
• W3183286210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8315016" @default.
• W3183286210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34326697" @default.
• W3183286210 hasPublicationYear "2021" @default.
• W3183286210 type Work @default.
• W3183286210 sameAs 3183286210 @default.
• W3183286210 citedByCount "83" @default.
• W3183286210 countsByYear W31832862102021 @default.
• W3183286210 countsByYear W31832862102022 @default.
• W3183286210 countsByYear W31832862102023 @default.
• W3183286210 crossrefType "journal-article" @default.
• W3183286210 hasAuthorship W3183286210A5000940922 @default.
• W3183286210 hasAuthorship W3183286210A5002203815 @default.
• W3183286210 hasAuthorship W3183286210A5021430966 @default.
• W3183286210 hasAuthorship W3183286210A5027036708 @default.
• W3183286210 hasAuthorship W3183286210A5039566796 @default.
• W3183286210 hasAuthorship W3183286210A5046538435 @default.
• W3183286210 hasAuthorship W3183286210A5077467339 @default.
• W3183286210 hasAuthorship W3183286210A5081525840 @default.
• W3183286210 hasAuthorship W3183286210A5082167565 @default.
• W3183286210 hasBestOaLocation W31832862101 @default.
• W3183286210 hasConcept C104317684 @default.
• W3183286210 hasConcept C121608353 @default.
• W3183286210 hasConcept C126322002 @default.
• W3183286210 hasConcept C127561419 @default.
• W3183286210 hasConcept C150903083 @default.
• W3183286210 hasConcept C17172800 @default.
• W3183286210 hasConcept C173396325 @default.
• W3183286210 hasConcept C185592680 @default.
• W3183286210 hasConcept C190283241 @default.
• W3183286210 hasConcept C207001950 @default.
• W3183286210 hasConcept C2776694085 @default.
• W3183286210 hasConcept C2778239845 @default.
• W3183286210 hasConcept C2780110267 @default.
• W3183286210 hasConcept C2781369401 @default.
• W3183286210 hasConcept C31573885 @default.
• W3183286210 hasConcept C502942594 @default.
• W3183286210 hasConcept C530470458 @default.
• W3183286210 hasConcept C55493867 @default.
• W3183286210 hasConcept C62203573 @default.
• W3183286210 hasConcept C71924100 @default.
• W3183286210 hasConcept C86803240 @default.
• W3183286210 hasConcept C95444343 @default.
• W3183286210 hasConceptScore W3183286210C104317684 @default.
• W3183286210 hasConceptScore W3183286210C121608353 @default.
• W3183286210 hasConceptScore W3183286210C126322002 @default.

• next