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- W3183292004 abstract "ABSTRACT Robust oscillation of clock genes is a core feature of the circadian system. Relative amplitude (rAMP) measures the robustness of clock gene oscillations, but only works for longitudinal samples. We lack a method for estimating robust oscillations from human samples without labeled time. We show that the normalized coefficient of variation (nCV) is linearly correlated with rAMP, independent of time labels. Using nCV, we found that clock gene oscillations are consistently dampened in tumors compared to non-tumors, suggesting a new therapeutic target in cancer treatment by enhancing clock robustness. nCV can provide a simple measure of the robustness of clock gene oscillations in any population-level dataset. Availability and implementation The nCV web application is available on the GitHub repository ( https://github.com/gangwug/nCV )." @default.
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- W3183292004 date "2021-07-29" @default.
- W3183292004 modified "2023-09-27" @default.
- W3183292004 title "Normalized coefficient of variation (nCV): a method to evaluate circadian clock robustness in population scale data" @default.
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- W3183292004 doi "https://doi.org/10.1101/2021.07.28.454045" @default.
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