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• W3183302620 abstract "• Serotype (cps) 1 of clonal complex 1 is an important pathotype in suckling piglets. • Cps 1 is currently more prevalent in Germany than cps 14. • S. suis cps 1 and cps 14 proliferate in porcine blood in presence of high IgG levels. • IgM restricts survival of S. suis cps 1 and 14 in blood of growing piglets. • Absorption of plasma with S. suis cps1 eliminates Ig mediating killing of cps14 . Streptococcus suis serotype ( cps ) 1 and cps 14 have been detected in association with severe diseases such as meningitis and polyarthritis in pigs. Though these two cps are very similar, only cps 14 is an important zoonotic agent in Asia and only cps 1 is described to be associated with diseases in suckling piglets rather than weaning piglets. The main objective of this study was to assess restriction of survival of cps 14 and cps 1 in porcine blood by IgG and IgM putatively cross-reacting with these two cps . Furthermore, we differentiate recent European cps 1/14 strains by agglutination, cps K sequencing, MLST and virulence-associated gene profiling. Our data confirmed cps 1 of clonal complex 1 as an important pathotype causing polyarthritis in suckling piglets in Europe. The experimental design included also bactericidal assays with blood samples drawn at different ages of piglets naturally infected with different S. suis cps types including cps 1 but not cps 14. We report survival of a cps 1 and a cps 14 strain (both of sequence type 1) in blood of suckling piglets with high levels of maternal IgG binding to the bacterial surface. In contrast, killing of cps 1 and cps 14 was recorded in older piglets due to an increase of IgM as demonstrated by specific cleavage of IgM. Heterologous absorption of antibodies with cps 1 or cps 14 is sufficient to significantly increase the survival of the other cps . In conclusion, IgM elicited by natural S. suis infection is crucial for killing of S. suis cps 1 and cps 14 in older weaning piglets and has most likely the potential to cross-react between cps 1 and cps 14." @default.
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• W3183302620 date "2021-09-01" @default.
• W3183302620 modified "2023-09-24" @default.
• W3183302620 title "Survival patterns of Streptococcus suis serotypes 1 and 14 in porcine blood indicate cross-reactive bactericidal antibodies in naturally infected pigs" @default.
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• W3183302620 doi "https://doi.org/10.1016/j.vetmic.2021.109183" @default.
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