Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183307679> ?p ?o ?g. }
- W3183307679 abstract "Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a higher level of stimulus. This review will consider the origins of this variability and heterogeneity, both in cells re-entering the cycle from quiescence and in the context of commitment decisions in continuously cycling populations. Particular attention will be paid to the role of two interacting molecular networks, namely the RB-E2F and APC/C CDH1 “switches.” These networks have the property of bistability and it seems likely that they are responsible for dynamic behavior previously described kinetically by Transition Probability models of the cell cycle. The relationship between these switches and the so-called Restriction Point of the cell cycle will also be considered." @default.
- W3183307679 created "2021-08-02" @default.
- W3183307679 creator A5017532387 @default.
- W3183307679 date "2021-07-23" @default.
- W3183307679 modified "2023-10-11" @default.
- W3183307679 title "Cell Cycle Commitment and the Origins of Cell Cycle Variability" @default.
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