FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183311704> ?p ?o ?g. }

• W3183311704 abstract "Abstract The availability of a simple, robust and non-invasive in vitro airway model would be useful to study the functionality of the cystic fibrosis transmembrane regulator (CFTR) protein and to personalize modulator therapy for cystic fibrosis (CF) patients. Our aim was to validate a CFTR functional study using nasospheroids, a patient-derived nasal cell 3D-culture. We performed live-cell experiments in nasospheroids obtained from wild-type individuals and CF patients with different genotypes and phenotypes. We extended the existing method and expanded the analysis to upgrade measurements of CFTR activity using forskolin-induced shrinking. We also tested modulator drugs in CF samples. Immobilizing suspended-nasospheroids provided a high number of samples for live-cell imaging. The diversity observed in basal sizes of nasospheroids did not affect the functional analysis of CFTR. Statistical analysis with our method was simple, making this protocol easy to reproduce. Moreover, we implemented the measurement of inner fluid reservoir areas to further differentiate CFTR functionality. In summary, this rapid methodology is helpful to analyse response to modulators in CF samples to allow individualized treatment for CF patients." @default.
• W3183311704 created "2021-08-02" @default.
• W3183311704 creator A5018526668 @default.
• W3183311704 creator A5020729469 @default.
• W3183311704 creator A5024495564 @default.
• W3183311704 creator A5061579532 @default.
• W3183311704 creator A5076225535 @default.
• W3183311704 creator A5086662554 @default.
• W3183311704 date "2021-07-30" @default.
• W3183311704 modified "2023-10-18" @default.
• W3183311704 title "Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis" @default.
• W3183311704 cites W146893853 @default.
• W3183311704 cites W1589654967 @default.
• W3183311704 cites W2035131077 @default.
• W3183311704 cites W2071407356 @default.
• W3183311704 cites W2115046089 @default.
• W3183311704 cites W2125391335 @default.
• W3183311704 cites W2138459782 @default.
• W3183311704 cites W2138844071 @default.
• W3183311704 cites W2151829259 @default.
• W3183311704 cites W2316431812 @default.
• W3183311704 cites W2465114161 @default.
• W3183311704 cites W2564673452 @default.
• W3183311704 cites W2734545712 @default.
• W3183311704 cites W2767840926 @default.
• W3183311704 cites W2770566651 @default.
• W3183311704 cites W2797726072 @default.
• W3183311704 cites W2799736418 @default.
• W3183311704 cites W2808871427 @default.
• W3183311704 cites W2808993718 @default.
• W3183311704 cites W2866605691 @default.
• W3183311704 cites W2888781195 @default.
• W3183311704 cites W2903274455 @default.
• W3183311704 cites W2911232211 @default.
• W3183311704 cites W2911418673 @default.
• W3183311704 cites W2955917209 @default.
• W3183311704 cites W2982296199 @default.
• W3183311704 cites W2985142745 @default.
• W3183311704 cites W2985405196 @default.
• W3183311704 cites W3021247470 @default.
• W3183311704 cites W3027664764 @default.
• W3183311704 cites W3032417039 @default.
• W3183311704 cites W3126875461 @default.
• W3183311704 cites W3161556901 @default.
• W3183311704 cites W4206217612 @default.
• W3183311704 cites W61678416 @default.
• W3183311704 doi "https://doi.org/10.1038/s41598-021-94798-x" @default.
• W3183311704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8324871" @default.
• W3183311704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34330959" @default.
• W3183311704 hasPublicationYear "2021" @default.
• W3183311704 type Work @default.
• W3183311704 sameAs 3183311704 @default.
• W3183311704 citedByCount "4" @default.
• W3183311704 countsByYear W31833117042022 @default.
• W3183311704 countsByYear W31833117042023 @default.
• W3183311704 crossrefType "journal-article" @default.
• W3183311704 hasAuthorship W3183311704A5018526668 @default.
• W3183311704 hasAuthorship W3183311704A5020729469 @default.
• W3183311704 hasAuthorship W3183311704A5024495564 @default.
• W3183311704 hasAuthorship W3183311704A5061579532 @default.
• W3183311704 hasAuthorship W3183311704A5076225535 @default.
• W3183311704 hasAuthorship W3183311704A5086662554 @default.
• W3183311704 hasBestOaLocation W31833117041 @default.
• W3183311704 hasConcept C104317684 @default.
• W3183311704 hasConcept C126322002 @default.
• W3183311704 hasConcept C127716648 @default.
• W3183311704 hasConcept C136229726 @default.
• W3183311704 hasConcept C1491633281 @default.
• W3183311704 hasConcept C202751555 @default.
• W3183311704 hasConcept C2776938444 @default.
• W3183311704 hasConcept C2778428886 @default.
• W3183311704 hasConcept C2779276759 @default.
• W3183311704 hasConcept C55493867 @default.
• W3183311704 hasConcept C70721500 @default.
• W3183311704 hasConcept C71924100 @default.
• W3183311704 hasConcept C86803240 @default.
• W3183311704 hasConceptScore W3183311704C104317684 @default.
• W3183311704 hasConceptScore W3183311704C126322002 @default.
• W3183311704 hasConceptScore W3183311704C127716648 @default.
• W3183311704 hasConceptScore W3183311704C136229726 @default.
• W3183311704 hasConceptScore W3183311704C1491633281 @default.
• W3183311704 hasConceptScore W3183311704C202751555 @default.
• W3183311704 hasConceptScore W3183311704C2776938444 @default.
• W3183311704 hasConceptScore W3183311704C2778428886 @default.
• W3183311704 hasConceptScore W3183311704C2779276759 @default.
• W3183311704 hasConceptScore W3183311704C55493867 @default.
• W3183311704 hasConceptScore W3183311704C70721500 @default.
• W3183311704 hasConceptScore W3183311704C71924100 @default.
• W3183311704 hasConceptScore W3183311704C86803240 @default.
• W3183311704 hasFunder F4320310220 @default.
• W3183311704 hasFunder F4320326356 @default.
• W3183311704 hasIssue "1" @default.
• W3183311704 hasLocation W31833117041 @default.
• W3183311704 hasLocation W31833117042 @default.
• W3183311704 hasLocation W31833117043 @default.
• W3183311704 hasOpenAccess W3183311704 @default.
• W3183311704 hasPrimaryLocation W31833117041 @default.
• W3183311704 hasRelatedWork W1977553340 @default.
• W3183311704 hasRelatedWork W1988867515 @default.
• W3183311704 hasRelatedWork W2052009539 @default.

• next