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• W3183334165 abstract "• CPF did not alter either learning, spatial memory or anxiety during late-adulthood. • Postnatal CPF exposure hyposensitized late adult rats to memory flexibility disruptions. • CPF exposure decreased motricity in both male and female rats during late adulthood. The molecular and behavioral effects of the developmental exposure to low doses of Chlorpyrifos (CPF) have been intensively studied in young (neonates and adolescents), and adult animals. However, no study examined influences of developmental CPF exposure in older adult or geriatric rats. This is relevant as such ages are generally linked to cognitive decline and the onset of specific neurodegenerative disorders, some of them previously associated with CPF exposure in both preclinical and human studies. 1 mg/kg/mL of CPF was orally administered to both male and female Wistar rats from Postnatal day 10 to 15. Animals’ spatial memory, learning, compulsivity, motricity, and anxiety were analyzed with Morris Water Maze (15–16 months of age) and the Plus-maze (at 18 months of age). Results showed that postnatal CPF exposure did not alter either spatial memory, compulsive-like behaviors, or anxiety levels in late-adult rats. However, CPF exposed rats were hyposensitive to brief disruptions (Probe stage) following the learning phase and showed a general decrease in locomotor activity in both paradigms. These data are relevant as it is the first time that developmental exposure to CPF has been studied at such a late age, observing important effects in locomotor activity that could be linked to specific pathologies previously associated with CPF effects in people. Future studies should extend these findings to other behaviors and molecular outcomes." @default.
• W3183334165 created "2021-08-02" @default.
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• W3183334165 date "2021-09-01" @default.
• W3183334165 modified "2023-09-29" @default.
• W3183334165 title "Pesticides and aging: Preweaning exposure to Chlorpyrifos induces a general hypomotricity state in late-adult rats" @default.
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• W3183334165 doi "https://doi.org/10.1016/j.neuro.2021.07.002" @default.
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