Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183406179> ?p ?o ?g. }
- W3183406179 endingPage "1872" @default.
- W3183406179 startingPage "1857" @default.
- W3183406179 abstract "The aim of this study was to investigate the distribution, tolerance, and anticancer and antiviral activity of Zn-based physiometacomposites (PMCs). Manganese, iron, nickel and cobalt-doped ZnO, ZnS or ZnSe were synthesized. Cell uptake, distribution into 3D culture and mice, and biochemical and chemotherapeutic activity were studied by fluorescence/bioluminescence, confocal microscopy, flow cytometry, viability, antitumor and virus titer assays. Luminescence and inductively coupled plasma mass spectrometry analysis showed that nanoparticle distribution was liver >spleen >kidney >lung >brain, without tissue or blood pathology. Photophysical characterization as ex vivo tissue probes and LL37 peptide, antisense oligomer or aptamer delivery targeting RAS/Ras binding domain (RBD) was investigated. Treatment at 25 μg/ml for 48 h showed ≥98–99% cell viability, 3D organoid uptake, 3-log inhibition of β-Galactosidase and porcine reproductive respiratory virus infection. Data support the preclinical development of PMCs for imaging and delivery targeting cancer and infectious disease." @default.
- W3183406179 created "2021-08-02" @default.
- W3183406179 creator A5000826412 @default.
- W3183406179 creator A5001108087 @default.
- W3183406179 creator A5001125895 @default.
- W3183406179 creator A5006445265 @default.
- W3183406179 creator A5012852135 @default.
- W3183406179 creator A5019632307 @default.
- W3183406179 creator A5024584048 @default.
- W3183406179 creator A5026895542 @default.
- W3183406179 creator A5044297783 @default.
- W3183406179 creator A5045748057 @default.
- W3183406179 creator A5050797480 @default.
- W3183406179 creator A5053940253 @default.
- W3183406179 creator A5055625709 @default.
- W3183406179 creator A5068422526 @default.
- W3183406179 creator A5072089519 @default.
- W3183406179 creator A5072227997 @default.
- W3183406179 creator A5077592017 @default.
- W3183406179 creator A5078784288 @default.
- W3183406179 creator A5080011333 @default.
- W3183406179 creator A5083356561 @default.
- W3183406179 creator A5083418828 @default.
- W3183406179 creator A5090069711 @default.
- W3183406179 date "2021-09-01" @default.
- W3183406179 modified "2023-10-16" @default.
- W3183406179 title "Zn-based physiometacomposite nanoparticles: distribution, tolerance, imaging, and antiviral and anticancer activity" @default.
- W3183406179 cites W1972678682 @default.
- W3183406179 cites W1994889271 @default.
- W3183406179 cites W2024468256 @default.
- W3183406179 cites W2028323511 @default.
- W3183406179 cites W2043058822 @default.
- W3183406179 cites W2052185625 @default.
- W3183406179 cites W2069254963 @default.
- W3183406179 cites W2148957240 @default.
- W3183406179 cites W2177623773 @default.
- W3183406179 cites W2253174922 @default.
- W3183406179 cites W2277885091 @default.
- W3183406179 cites W2314688747 @default.
- W3183406179 cites W2346816906 @default.
- W3183406179 cites W2475230193 @default.
- W3183406179 cites W2505837069 @default.
- W3183406179 cites W2581070612 @default.
- W3183406179 cites W2588299755 @default.
- W3183406179 cites W2600519390 @default.
- W3183406179 cites W2748300815 @default.
- W3183406179 cites W2749711951 @default.
- W3183406179 cites W2774956742 @default.
- W3183406179 cites W2806509900 @default.
- W3183406179 cites W2901919387 @default.
- W3183406179 cites W2943687418 @default.
- W3183406179 cites W2960112131 @default.
- W3183406179 cites W2972743302 @default.
- W3183406179 cites W2998342219 @default.
- W3183406179 cites W3026581384 @default.
- W3183406179 cites W3036498507 @default.
- W3183406179 cites W3040677640 @default.
- W3183406179 cites W3127206670 @default.
- W3183406179 cites W3148115595 @default.
- W3183406179 doi "https://doi.org/10.2217/nnm-2021-0179" @default.
- W3183406179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34282923" @default.
- W3183406179 hasPublicationYear "2021" @default.
- W3183406179 type Work @default.
- W3183406179 sameAs 3183406179 @default.
- W3183406179 citedByCount "5" @default.
- W3183406179 countsByYear W31834061792021 @default.
- W3183406179 countsByYear W31834061792022 @default.
- W3183406179 countsByYear W31834061792023 @default.
- W3183406179 crossrefType "journal-article" @default.
- W3183406179 hasAuthorship W3183406179A5000826412 @default.
- W3183406179 hasAuthorship W3183406179A5001108087 @default.
- W3183406179 hasAuthorship W3183406179A5001125895 @default.
- W3183406179 hasAuthorship W3183406179A5006445265 @default.
- W3183406179 hasAuthorship W3183406179A5012852135 @default.
- W3183406179 hasAuthorship W3183406179A5019632307 @default.
- W3183406179 hasAuthorship W3183406179A5024584048 @default.
- W3183406179 hasAuthorship W3183406179A5026895542 @default.
- W3183406179 hasAuthorship W3183406179A5044297783 @default.
- W3183406179 hasAuthorship W3183406179A5045748057 @default.
- W3183406179 hasAuthorship W3183406179A5050797480 @default.
- W3183406179 hasAuthorship W3183406179A5053940253 @default.
- W3183406179 hasAuthorship W3183406179A5055625709 @default.
- W3183406179 hasAuthorship W3183406179A5068422526 @default.
- W3183406179 hasAuthorship W3183406179A5072089519 @default.
- W3183406179 hasAuthorship W3183406179A5072227997 @default.
- W3183406179 hasAuthorship W3183406179A5077592017 @default.
- W3183406179 hasAuthorship W3183406179A5078784288 @default.
- W3183406179 hasAuthorship W3183406179A5080011333 @default.
- W3183406179 hasAuthorship W3183406179A5083356561 @default.
- W3183406179 hasAuthorship W3183406179A5083418828 @default.
- W3183406179 hasAuthorship W3183406179A5090069711 @default.
- W3183406179 hasConcept C104317684 @default.
- W3183406179 hasConcept C111335760 @default.
- W3183406179 hasConcept C142724271 @default.
- W3183406179 hasConcept C1491633281 @default.
- W3183406179 hasConcept C150903083 @default.
- W3183406179 hasConcept C153911025 @default.
- W3183406179 hasConcept C161997846 @default.