FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183554099> ?p ?o ?g. }

• W3183554099 endingPage "121037" @default.
• W3183554099 startingPage "121037" @default.
• W3183554099 abstract "Three-dimension (3D)-printed bioscaffolds are precise and personalized for bone regeneration. However, customized 3D scaffolds may activate the immune response in vivo and consequently impede bone formation. In this study, with layer-by-layer deposition and electrospinning technology to control the physical structure, 3D-printed PCL scaffolds with PLLA electrospun microfibrous (3D-M-EF) and nanofibrous (3D-N-EF) composites were constructed, and their immunomodulatory effect and the subsequent osteogenic effects were explored. Compared to 3D-N-EF scaffolds, 3D-M-EF scaffolds polarized more RAW264.7 cells toward alternatively activated macrophages (M2), as demonstrated by increased M2 and deceased classically activated macrophage (M1) phenotypic marker expression in the cells. In addition, the 3D-M-EF scaffolds shifted RAW264.7 cells to the M2 phenotype through PI3K/AKT signaling and enhanced VEGF and BMP-2 expression. Conditional medium from the RAW264.7 cells seeded in 3D-M-EF scaffolds promoted osteogenesis of MC3T3-E1 cells. Furthermore, in vivo study of repairing rat calvarial defects, the 3D-M-EF scaffolds increased the polarization of M2 macrophages, enhanced angiogenesis, and accelerated new bone formation. Collectively, our data suggested that well-designed 3D-M-EF scaffolds are favorable for osteogenesis through regulation of M2 polarization. Therefore, it is potential to utilize the physical structure of 3D-printed scaffolds to manipulate the osteoimmune environment to promote bone regeneration." @default.
• W3183554099 created "2021-08-02" @default.
• W3183554099 creator A5016780203 @default.
• W3183554099 creator A5020419888 @default.
• W3183554099 creator A5024040157 @default.
• W3183554099 creator A5042318166 @default.
• W3183554099 creator A5047054215 @default.
• W3183554099 creator A5060407730 @default.
• W3183554099 creator A5062773885 @default.
• W3183554099 creator A5080358275 @default.
• W3183554099 creator A5085065266 @default.
• W3183554099 creator A5085108319 @default.
• W3183554099 date "2021-09-01" @default.
• W3183554099 modified "2023-10-14" @default.
• W3183554099 title "Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration" @default.
• W3183554099 cites W1797422316 @default.
• W3183554099 cites W1995063875 @default.
• W3183554099 cites W2005651032 @default.
• W3183554099 cites W2006012075 @default.
• W3183554099 cites W2011335750 @default.
• W3183554099 cites W2014337155 @default.
• W3183554099 cites W2045746876 @default.
• W3183554099 cites W2054472394 @default.
• W3183554099 cites W2056336363 @default.
• W3183554099 cites W2058522210 @default.
• W3183554099 cites W2070438219 @default.
• W3183554099 cites W2072172632 @default.
• W3183554099 cites W2090827542 @default.
• W3183554099 cites W2159560463 @default.
• W3183554099 cites W2234275440 @default.
• W3183554099 cites W2343832243 @default.
• W3183554099 cites W2444260301 @default.
• W3183554099 cites W2520622343 @default.
• W3183554099 cites W2553403150 @default.
• W3183554099 cites W2582393724 @default.
• W3183554099 cites W2604208883 @default.
• W3183554099 cites W2618335441 @default.
• W3183554099 cites W2737721978 @default.
• W3183554099 cites W2757209889 @default.
• W3183554099 cites W2769868849 @default.
• W3183554099 cites W2791240372 @default.
• W3183554099 cites W2794435788 @default.
• W3183554099 cites W2838827263 @default.
• W3183554099 cites W2893598894 @default.
• W3183554099 cites W2899366145 @default.
• W3183554099 cites W2909489811 @default.
• W3183554099 cites W2913717099 @default.
• W3183554099 cites W2927241068 @default.
• W3183554099 cites W2945534715 @default.
• W3183554099 cites W2964723225 @default.
• W3183554099 cites W2974242780 @default.
• W3183554099 cites W2980744043 @default.
• W3183554099 cites W3011869487 @default.
• W3183554099 cites W3011988507 @default.
• W3183554099 cites W3024405114 @default.
• W3183554099 cites W3024685707 @default.
• W3183554099 cites W3036199809 @default.
• W3183554099 cites W3038675181 @default.
• W3183554099 cites W3054037622 @default.
• W3183554099 cites W3080418090 @default.
• W3183554099 cites W3094314302 @default.
• W3183554099 cites W3112950318 @default.
• W3183554099 cites W3123838846 @default.
• W3183554099 cites W4233378497 @default.
• W3183554099 doi "https://doi.org/10.1016/j.biomaterials.2021.121037" @default.
• W3183554099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34325336" @default.
• W3183554099 hasPublicationYear "2021" @default.
• W3183554099 type Work @default.
• W3183554099 sameAs 3183554099 @default.
• W3183554099 citedByCount "64" @default.
• W3183554099 countsByYear W31835540992021 @default.
• W3183554099 countsByYear W31835540992022 @default.
• W3183554099 countsByYear W31835540992023 @default.
• W3183554099 crossrefType "journal-article" @default.
• W3183554099 hasAuthorship W3183554099A5016780203 @default.
• W3183554099 hasAuthorship W3183554099A5020419888 @default.
• W3183554099 hasAuthorship W3183554099A5024040157 @default.
• W3183554099 hasAuthorship W3183554099A5042318166 @default.
• W3183554099 hasAuthorship W3183554099A5047054215 @default.
• W3183554099 hasAuthorship W3183554099A5060407730 @default.
• W3183554099 hasAuthorship W3183554099A5062773885 @default.
• W3183554099 hasAuthorship W3183554099A5080358275 @default.
• W3183554099 hasAuthorship W3183554099A5085065266 @default.
• W3183554099 hasAuthorship W3183554099A5085108319 @default.
• W3183554099 hasConcept C136229726 @default.
• W3183554099 hasConcept C144796933 @default.
• W3183554099 hasConcept C150903083 @default.
• W3183554099 hasConcept C159985019 @default.
• W3183554099 hasConcept C171056886 @default.
• W3183554099 hasConcept C171250308 @default.
• W3183554099 hasConcept C185592680 @default.
• W3183554099 hasConcept C192562407 @default.
• W3183554099 hasConcept C202751555 @default.
• W3183554099 hasConcept C207001950 @default.
• W3183554099 hasConcept C2776682551 @default.
• W3183554099 hasConcept C2779244956 @default.
• W3183554099 hasConcept C2780394083 @default.
• W3183554099 hasConcept C3019308078 @default.

• next