FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183593669> ?p ?o ?g. }

• W3183593669 abstract "ABSTRACT RNA Polymerase III (Pol III) transcribes noncoding RNA, including transfer RNA (tRNA), and acts as a pathogen sensor during the innate immune response. To promote enhanced proliferation, the Pol III machinery is commonly targeted during cancer and viral infection. Herein we employ DM-RNA-Seq, 4SU-Seq, ChIP-Seq, and ATAC-Seq to characterize how Herpes Simplex Virus-1 (HSV-1) perturbs the Pol III landscape. We find that HSV-1 stimulates tRNA expression 10-fold, with mature tRNAs exhibiting a 2-fold increase within 12 hours of infection. Perturbation of host tRNA synthesis requires nuclear viral entry, but not synthesis of specific viral transcripts, nascent viral genomes, or viral progeny. Host tRNA with a specific codon bias were not targeted—rather increased transcription was observed from euchromatic, actively transcribed loci. tRNA upregulation is linked to unique crosstalk between the Pol II and III transcriptional machinery. While viral infection is known to mediate host transcriptional shut off and lead to a depletion of Pol II on host mRNA promoters, we find that Pol II binding to tRNA loci increases. Finally, we report Pol III and associated factors bind the HSV genome, which suggests a previously unrecognized role in HSV-1 gene expression. These data provide insight into novel mechanisms by which HSV-1 alters the host nuclear environment, shifting key processes in favor of the pathogen." @default.
• W3183593669 created "2021-08-02" @default.
• W3183593669 creator A5016104237 @default.
• W3183593669 creator A5022641334 @default.
• W3183593669 creator A5028063031 @default.
• W3183593669 creator A5036113082 @default.
• W3183593669 creator A5082742080 @default.
• W3183593669 date "2021-07-23" @default.
• W3183593669 modified "2023-10-15" @default.
• W3183593669 title "Manipulation of RNA Polymerase III by Herpes Simplex Virus-1" @default.
• W3183593669 cites W1490731141 @default.
• W3183593669 cites W1503107508 @default.
• W3183593669 cites W1540296073 @default.
• W3183593669 cites W1561297384 @default.
• W3183593669 cites W1583466448 @default.
• W3183593669 cites W1606562486 @default.
• W3183593669 cites W1738338042 @default.
• W3183593669 cites W1767644833 @default.
• W3183593669 cites W1788895899 @default.
• W3183593669 cites W1824684517 @default.
• W3183593669 cites W1912540205 @default.
• W3183593669 cites W1962970685 @default.
• W3183593669 cites W1965530946 @default.
• W3183593669 cites W1974786493 @default.
• W3183593669 cites W1978202804 @default.
• W3183593669 cites W1980477679 @default.
• W3183593669 cites W1986789987 @default.
• W3183593669 cites W1996339094 @default.
• W3183593669 cites W2002694645 @default.
• W3183593669 cites W2005090326 @default.
• W3183593669 cites W2016131266 @default.
• W3183593669 cites W2019546125 @default.
• W3183593669 cites W2031347517 @default.
• W3183593669 cites W2035779570 @default.
• W3183593669 cites W2036649644 @default.
• W3183593669 cites W2040114529 @default.
• W3183593669 cites W2048461084 @default.
• W3183593669 cites W2049137101 @default.
• W3183593669 cites W2049982348 @default.
• W3183593669 cites W2054274307 @default.
• W3183593669 cites W2056295530 @default.
• W3183593669 cites W2060262242 @default.
• W3183593669 cites W2066251617 @default.
• W3183593669 cites W2066341715 @default.
• W3183593669 cites W2083829813 @default.
• W3183593669 cites W2088578552 @default.
• W3183593669 cites W2089315523 @default.
• W3183593669 cites W2095254687 @default.
• W3183593669 cites W2095475642 @default.
• W3183593669 cites W2095557476 @default.
• W3183593669 cites W2095963288 @default.
• W3183593669 cites W2101202684 @default.
• W3183593669 cites W2101528846 @default.
• W3183593669 cites W2102278945 @default.
• W3183593669 cites W2108658982 @default.
• W3183593669 cites W2110120221 @default.
• W3183593669 cites W2114147818 @default.
• W3183593669 cites W2114725983 @default.
• W3183593669 cites W2116949284 @default.
• W3183593669 cites W2119232680 @default.
• W3183593669 cites W2129129906 @default.
• W3183593669 cites W2138207763 @default.
• W3183593669 cites W2138257095 @default.
• W3183593669 cites W2140178603 @default.
• W3183593669 cites W2142756909 @default.
• W3183593669 cites W2155374876 @default.
• W3183593669 cites W2159144690 @default.
• W3183593669 cites W2166639080 @default.
• W3183593669 cites W2169401299 @default.
• W3183593669 cites W2170551349 @default.
• W3183593669 cites W2186287815 @default.
• W3183593669 cites W2203588018 @default.
• W3183593669 cites W2223836536 @default.
• W3183593669 cites W2333689301 @default.
• W3183593669 cites W2341539131 @default.
• W3183593669 cites W2393535458 @default.
• W3183593669 cites W2565214472 @default.
• W3183593669 cites W2770844838 @default.
• W3183593669 cites W2890219238 @default.
• W3183593669 cites W2913961265 @default.
• W3183593669 cites W2917207851 @default.
• W3183593669 cites W2942748350 @default.
• W3183593669 cites W2982129603 @default.
• W3183593669 cites W3017295488 @default.
• W3183593669 cites W3092023186 @default.
• W3183593669 cites W418058786 @default.
• W3183593669 doi "https://doi.org/10.1101/2021.07.21.453214" @default.
• W3183593669 hasPublicationYear "2021" @default.
• W3183593669 type Work @default.
• W3183593669 sameAs 3183593669 @default.
• W3183593669 citedByCount "1" @default.
• W3183593669 countsByYear W31835936692022 @default.
• W3183593669 crossrefType "posted-content" @default.
• W3183593669 hasAuthorship W3183593669A5016104237 @default.
• W3183593669 hasAuthorship W3183593669A5022641334 @default.
• W3183593669 hasAuthorship W3183593669A5028063031 @default.
• W3183593669 hasAuthorship W3183593669A5036113082 @default.
• W3183593669 hasAuthorship W3183593669A5082742080 @default.
• W3183593669 hasBestOaLocation W31835936691 @default.
• W3183593669 hasConcept C101762097 @default.

• next