FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183669248> ?p ?o ?g. }

• W3183669248 endingPage "100676" @default.
• W3183669248 startingPage "100676" @default.
• W3183669248 abstract "Small cell lung cancer (SCLC) is characterized by accelerated growth and early metastasis, making it a vigorous and deadly cancer. The majority of the patients relapse quickly and show a bad prognosis even after responding to earlier chemotherapy. Because of their high selectivity and effectiveness, immunotoxin is a promising anticancer therapy. In recent years, the progressions in immunology based knowledge, data and techniques have made it possible to construct immunotoxins in silico with favorable efficiency. The CXCR4 receptor is utilized as the target for SCLC. CXCL12 chemokine is coupled with Pseudomonas aeruginosa exotoxin A (PE) which is expected to show cytotoxicity at the target SCLC cells. The physiochemical properties of the developed IT showed promising results. The predicted 3D structure of the immunotoxin was evaluated with Ramachandran plot analysis and Z-score. A total of 99.6% amino acid residues of IT belonged to the favored region. Additionally, Molecular docking between IT and CXCR4 was estimated to bind with a higher affinity and a lower binding energy of −15.21 kcal/mol. Furthermore, a molecular dynamic simulation was conducted to determine RMSD, RMSF, Radius of Gyration (Rg), B-factor for evaluating the stability of IT-CXCR4 complex. Finally, further assessments through in vitro and in vivo methods should be performed to validate the IT construct." @default.
• W3183669248 created "2021-08-02" @default.
• W3183669248 creator A5062767831 @default.
• W3183669248 date "2021-01-01" @default.
• W3183669248 modified "2023-10-16" @default.
• W3183669248 title "Development of chemokine CXCL12-dependent immunotoxin against small cell lung cancer using in silico approaches" @default.
• W3183669248 cites W1538172609 @default.
• W3183669248 cites W1738289412 @default.
• W3183669248 cites W1896473474 @default.
• W3183669248 cites W1964341187 @default.
• W3183669248 cites W1989873812 @default.
• W3183669248 cites W1998917415 @default.
• W3183669248 cites W2004635420 @default.
• W3183669248 cites W2009906055 @default.
• W3183669248 cites W2013107571 @default.
• W3183669248 cites W2017955769 @default.
• W3183669248 cites W2018448673 @default.
• W3183669248 cites W2024417034 @default.
• W3183669248 cites W2025190578 @default.
• W3183669248 cites W2041389038 @default.
• W3183669248 cites W2069928082 @default.
• W3183669248 cites W2080876451 @default.
• W3183669248 cites W2081921364 @default.
• W3183669248 cites W2102023232 @default.
• W3183669248 cites W2106443011 @default.
• W3183669248 cites W2113472355 @default.
• W3183669248 cites W2124472345 @default.
• W3183669248 cites W2127530853 @default.
• W3183669248 cites W2133147483 @default.
• W3183669248 cites W2133425774 @default.
• W3183669248 cites W2152630148 @default.
• W3183669248 cites W2153102800 @default.
• W3183669248 cites W2153255725 @default.
• W3183669248 cites W2156323704 @default.
• W3183669248 cites W2159102253 @default.
• W3183669248 cites W2549745345 @default.
• W3183669248 cites W2555799286 @default.
• W3183669248 cites W2582015180 @default.
• W3183669248 cites W2589339555 @default.
• W3183669248 cites W2742763599 @default.
• W3183669248 cites W2753004811 @default.
• W3183669248 cites W2790710405 @default.
• W3183669248 cites W2889004474 @default.
• W3183669248 cites W2889646458 @default.
• W3183669248 cites W2895926103 @default.
• W3183669248 cites W2918297277 @default.
• W3183669248 cites W2941112903 @default.
• W3183669248 cites W2945172910 @default.
• W3183669248 cites W2980347658 @default.
• W3183669248 cites W2993893341 @default.
• W3183669248 cites W3000335462 @default.
• W3183669248 cites W3010839046 @default.
• W3183669248 cites W3120320954 @default.
• W3183669248 cites W4242982114 @default.
• W3183669248 cites W629562313 @default.
• W3183669248 doi "https://doi.org/10.1016/j.imu.2021.100676" @default.
• W3183669248 hasPublicationYear "2021" @default.
• W3183669248 type Work @default.
• W3183669248 sameAs 3183669248 @default.
• W3183669248 citedByCount "2" @default.
• W3183669248 countsByYear W31836692482022 @default.
• W3183669248 crossrefType "journal-article" @default.
• W3183669248 hasAuthorship W3183669248A5062767831 @default.
• W3183669248 hasBestOaLocation W31836692481 @default.
• W3183669248 hasConcept C104317684 @default.
• W3183669248 hasConcept C109316439 @default.
• W3183669248 hasConcept C115085202 @default.
• W3183669248 hasConcept C129470790 @default.
• W3183669248 hasConcept C13373296 @default.
• W3183669248 hasConcept C143998085 @default.
• W3183669248 hasConcept C150903083 @default.
• W3183669248 hasConcept C182179738 @default.
• W3183669248 hasConcept C185592680 @default.
• W3183669248 hasConcept C202751555 @default.
• W3183669248 hasConcept C203014093 @default.
• W3183669248 hasConcept C207001950 @default.
• W3183669248 hasConcept C2775905019 @default.
• W3183669248 hasConcept C2776256026 @default.
• W3183669248 hasConcept C2780492938 @default.
• W3183669248 hasConcept C502942594 @default.
• W3183669248 hasConcept C55493867 @default.
• W3183669248 hasConcept C71924100 @default.
• W3183669248 hasConcept C86803240 @default.
• W3183669248 hasConcept C8891405 @default.
• W3183669248 hasConceptScore W3183669248C104317684 @default.
• W3183669248 hasConceptScore W3183669248C109316439 @default.
• W3183669248 hasConceptScore W3183669248C115085202 @default.
• W3183669248 hasConceptScore W3183669248C129470790 @default.
• W3183669248 hasConceptScore W3183669248C13373296 @default.
• W3183669248 hasConceptScore W3183669248C143998085 @default.
• W3183669248 hasConceptScore W3183669248C150903083 @default.
• W3183669248 hasConceptScore W3183669248C182179738 @default.
• W3183669248 hasConceptScore W3183669248C185592680 @default.
• W3183669248 hasConceptScore W3183669248C202751555 @default.
• W3183669248 hasConceptScore W3183669248C203014093 @default.
• W3183669248 hasConceptScore W3183669248C207001950 @default.
• W3183669248 hasConceptScore W3183669248C2775905019 @default.
• W3183669248 hasConceptScore W3183669248C2776256026 @default.

• next