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- W3183669650 startingPage "2374" @default.
- W3183669650 abstract "RNA regulates myriad cellular events such as transcription, translation, and splicing. To perform these essential functions, RNA often folds into complex tertiary structures in which its negatively charged ribose-phosphate backbone interacts with metal ions. Magnesium, the most abundant divalent metal ion in cells, neutralizes the backbone, thereby playing essential roles in RNA folding and function. This has been known for more than 50 years, and there are now thousands of in vitro studies, most of which have used ≥10 mM free Mg2+ ions to achieve optimal RNA folding and function. In the cell, however, concentrations of free Mg2+ ions are much lower, with most Mg2+ ions chelated by metabolites. In this Perspective, we curate data from a number of sources to provide extensive summaries of cellular concentrations of metabolites that bind Mg2+ and to estimate cellular concentrations of metabolite-chelated Mg2+ species, in the representative prokaryotic and eukaryotic systems Escherichia coli, Saccharomyces cerevisiae, and iBMK cells. Recent research from our lab and others has uncovered the fact that such weakly chelated Mg2+ ions can enhance RNA function, including its thermodynamic stability, chemical stability, and catalysis. We also discuss how metabolite-chelated Mg2+ complexes may have played roles in the origins of life. It is clear from this analysis that bound Mg2+ should not be simply considered non-RNA-interacting and that future RNA research, as well as protein research, could benefit from considering chelated magnesium." @default.
- W3183669650 created "2021-08-02" @default.
- W3183669650 creator A5000325415 @default.
- W3183669650 creator A5053201698 @default.
- W3183669650 creator A5081661848 @default.
- W3183669650 date "2021-07-28" @default.
- W3183669650 modified "2023-10-12" @default.
- W3183669650 title "Functional Roles of Chelated Magnesium Ions in RNA Folding and Function" @default.
- W3183669650 cites W102942757 @default.
- W3183669650 cites W122943423 @default.
- W3183669650 cites W1507472185 @default.
- W3183669650 cites W1513228388 @default.
- W3183669650 cites W1550830311 @default.
- W3183669650 cites W1771048168 @default.
- W3183669650 cites W1794884242 @default.
- W3183669650 cites W1901248126 @default.
- W3183669650 cites W1935442479 @default.
- W3183669650 cites W1964261732 @default.
- W3183669650 cites W1967964705 @default.
- W3183669650 cites W1970441908 @default.
- W3183669650 cites W1974000520 @default.
- W3183669650 cites W1974259661 @default.
- W3183669650 cites W1981280704 @default.
- W3183669650 cites W1990447102 @default.
- W3183669650 cites W1990661195 @default.
- W3183669650 cites W1990886999 @default.
- W3183669650 cites W1993490997 @default.
- W3183669650 cites W2000656899 @default.
- W3183669650 cites W2004181413 @default.
- W3183669650 cites W2004235182 @default.
- W3183669650 cites W2006858059 @default.
- W3183669650 cites W2010038629 @default.
- W3183669650 cites W2011722931 @default.
- W3183669650 cites W2012578900 @default.
- W3183669650 cites W2017716866 @default.
- W3183669650 cites W2018038200 @default.
- W3183669650 cites W2028264413 @default.
- W3183669650 cites W2035594105 @default.
- W3183669650 cites W2038241057 @default.
- W3183669650 cites W2039133207 @default.
- W3183669650 cites W2041882488 @default.
- W3183669650 cites W2045194452 @default.
- W3183669650 cites W2050647031 @default.
- W3183669650 cites W2051713039 @default.
- W3183669650 cites W2053595351 @default.
- W3183669650 cites W2053710579 @default.
- W3183669650 cites W2055168495 @default.
- W3183669650 cites W2056975726 @default.
- W3183669650 cites W2060872711 @default.
- W3183669650 cites W2068205741 @default.
- W3183669650 cites W2069122773 @default.
- W3183669650 cites W2076091642 @default.
- W3183669650 cites W2079800805 @default.
- W3183669650 cites W2080036209 @default.
- W3183669650 cites W2084781504 @default.
- W3183669650 cites W2084841438 @default.
- W3183669650 cites W2085903676 @default.
- W3183669650 cites W2089644153 @default.
- W3183669650 cites W2095438221 @default.
- W3183669650 cites W2105120377 @default.
- W3183669650 cites W2113525941 @default.
- W3183669650 cites W2114562270 @default.
- W3183669650 cites W2114702358 @default.
- W3183669650 cites W2121891865 @default.
- W3183669650 cites W2132976721 @default.
- W3183669650 cites W2134816300 @default.
- W3183669650 cites W2136524572 @default.
- W3183669650 cites W2141776893 @default.
- W3183669650 cites W2155376412 @default.
- W3183669650 cites W2164552624 @default.
- W3183669650 cites W2170998674 @default.
- W3183669650 cites W2171945056 @default.
- W3183669650 cites W2267335000 @default.
- W3183669650 cites W2300135289 @default.
- W3183669650 cites W2331543036 @default.
- W3183669650 cites W2346094579 @default.
- W3183669650 cites W2463016798 @default.
- W3183669650 cites W2474315578 @default.
- W3183669650 cites W2531041501 @default.
- W3183669650 cites W2553023937 @default.
- W3183669650 cites W2585853365 @default.
- W3183669650 cites W2730372362 @default.
- W3183669650 cites W2767747597 @default.
- W3183669650 cites W2782801659 @default.
- W3183669650 cites W2795718064 @default.
- W3183669650 cites W2802049840 @default.
- W3183669650 cites W2807593658 @default.
- W3183669650 cites W2895041728 @default.
- W3183669650 cites W2912127110 @default.
- W3183669650 cites W2949078846 @default.
- W3183669650 cites W2972781930 @default.
- W3183669650 cites W2982293539 @default.
- W3183669650 cites W3024057275 @default.
- W3183669650 cites W3042057003 @default.
- W3183669650 cites W3107483306 @default.
- W3183669650 cites W3108439960 @default.
- W3183669650 cites W4206100856 @default.
- W3183669650 cites W4253470710 @default.