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- W3183669929 abstract "Incorporation of cationic groups into polymers represents one of the most widely used strategies to prepare antibacterial materials. Sulfonium, as a typical cationic moiety, displays potent antibacterial efficacy in the form of small molecules, however, has long underperformed in polymeric systems. Herein, we developed a series of alternating polysulfoniums, where the hydrophobicity of each alternating unit can be accurately tuned by altering the monomer precursors. Excellent antibacterial activity against a broad spectrum of clinically relevant bacteria, including Methicillin-resistant Staphylococcus aureus, can be obtained in the optimal compositions with minimum bactericidal concentrations in the range of 1.25-10 μg/mL, as well as negligible hemolytic effect at polymer concentrations even up to 10000 μg/mL. Bacteria do not readily develop resistance to polysulfoniums due to the antibacterial action is possibly the membrane disrupting mechanism. This work demonstrates sulfonium-based polymers with well-defined sequences can function as a promising candidate to combat drug-resistant bacterial infection." @default.
- W3183669929 created "2021-08-02" @default.
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- W3183669929 date "2021-07-15" @default.
- W3183669929 modified "2023-10-16" @default.
- W3183669929 title "Broad-Spectrum Bactericidal Activity and Remarkable Selectivity of Main-Chain Sulfonium-Containing Polymers with Alternating Sequences" @default.
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- W3183669929 doi "https://doi.org/10.1021/acsmacrolett.1c00340" @default.
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