Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183708017> ?p ?o ?g. }
- W3183708017 abstract "Immunotherapy has emerged as a promising approach to treating several forms of cancer. Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and antibodies through antibody dependent cell-mediated cytotoxicity (ADCC) has been investigated as a potential combination therapy for some difficult to treat solid tumors. Nevertheless, there remains a need to develop tools that support co-culture of target cancer cells and effector immune cells in a contextually relevant three-dimensional (3D) environment to provide a rapid means to screen for and optimize ADCC-drug combinations. To that end, here we have developed a high throughput 330 micropillar-microwell sandwich platform that enables 3D co-culture of NK92-CD16 cells with pancreatic (MiaPaCa-2) and breast cancer cell lines (MCF-7 and MDA-MB-231). The platform successfully mimicked hypoxic conditions found in a tumor microenvironment and was used to demonstrate NK-cell mediated cell cytotoxicity in combination with two monoclonal antibodies; Trastuzumab and Atezolizumab. The platform was also used to show dose response behavior of target cancer cells with reduced EC50 values for paclitaxel (an anti-cancer chemotherapeutic) when treated with both NK cells and antibody. Such a platform may be used to develop more personalized cancer therapies using patient-derived cancer cells." @default.
- W3183708017 created "2021-08-02" @default.
- W3183708017 creator A5007771637 @default.
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- W3183708017 creator A5043855114 @default.
- W3183708017 creator A5058602855 @default.
- W3183708017 creator A5085010633 @default.
- W3183708017 date "2021-07-21" @default.
- W3183708017 modified "2023-10-03" @default.
- W3183708017 title "3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity" @default.
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- W3183708017 doi "https://doi.org/10.1038/s42003-021-02417-2" @default.
- W3183708017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8295284" @default.
- W3183708017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34290356" @default.
- W3183708017 hasPublicationYear "2021" @default.
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