Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183739280> ?p ?o ?g. }
- W3183739280 endingPage "e1009764" @default.
- W3183739280 startingPage "e1009764" @default.
- W3183739280 abstract "Both Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) establish the persistent, life-long infection primarily at the latent status, and associate with certain types of tumors, such as B cell lymphomas, especially in immuno-compromised individuals including people living with HIV (PLWH). Lytic reactivation of these viruses can be employed to kill tumor cells harboring latently infected viral episomes through the viral cytopathic effects and the subsequent antiviral immune responses. In this study, we identified that polo-like kinase 1 (PLK1) is induced by KSHV de novo infection as well as lytic switch from KSHV latency. We further demonstrated that PLK1 depletion or inhibition facilitates KSHV reactivation and promotes cell death of KSHV-infected lymphoma cells. Mechanistically, PLK1 regulates Myc that is critical to both maintenance of KSHV latency and support of cell survival, and preferentially affects the level of H3K27me3 inactive mark both globally and at certain loci of KSHV viral episomes. Furthremore, we recognized that PLK1 inhibition synergizes with STAT3 inhibition to efficiently induce KSHV reactivation. We also confirmed that PLK1 depletion or inhibition yields the similar effect on EBV lytic reactivation and cell death of EBV-infected lymphoma cells. Lastly, we noticed that PLK1 in B cells is elevated in the context of HIV infection and caused by HIV Nef protein to favor KSHV/EBV latency." @default.
- W3183739280 created "2021-08-02" @default.
- W3183739280 creator A5005192531 @default.
- W3183739280 creator A5021843274 @default.
- W3183739280 creator A5022408570 @default.
- W3183739280 creator A5031062133 @default.
- W3183739280 creator A5051862250 @default.
- W3183739280 creator A5060287743 @default.
- W3183739280 creator A5079177940 @default.
- W3183739280 creator A5084593228 @default.
- W3183739280 creator A5091313888 @default.
- W3183739280 date "2021-07-23" @default.
- W3183739280 modified "2023-10-14" @default.
- W3183739280 title "Inhibition of polo-like kinase 1 (PLK1) facilitates reactivation of gamma-herpesviruses and their elimination" @default.
- W3183739280 cites W1774895213 @default.
- W3183739280 cites W1795403715 @default.
- W3183739280 cites W1970339166 @default.
- W3183739280 cites W1970757470 @default.
- W3183739280 cites W1978130054 @default.
- W3183739280 cites W1986548436 @default.
- W3183739280 cites W2008004643 @default.
- W3183739280 cites W2014571799 @default.
- W3183739280 cites W2014744254 @default.
- W3183739280 cites W2015863723 @default.
- W3183739280 cites W2019807707 @default.
- W3183739280 cites W2025615902 @default.
- W3183739280 cites W2028483614 @default.
- W3183739280 cites W2032438721 @default.
- W3183739280 cites W2036238945 @default.
- W3183739280 cites W2037874673 @default.
- W3183739280 cites W2044484966 @default.
- W3183739280 cites W2045493291 @default.
- W3183739280 cites W2049069843 @default.
- W3183739280 cites W2052613054 @default.
- W3183739280 cites W2054101834 @default.
- W3183739280 cites W2054492080 @default.
- W3183739280 cites W2061021700 @default.
- W3183739280 cites W2067444184 @default.
- W3183739280 cites W2072981794 @default.
- W3183739280 cites W2074871929 @default.
- W3183739280 cites W2075807666 @default.
- W3183739280 cites W2076750567 @default.
- W3183739280 cites W2084086052 @default.
- W3183739280 cites W2092627144 @default.
- W3183739280 cites W2115268409 @default.
- W3183739280 cites W2122809296 @default.
- W3183739280 cites W2134979684 @default.
- W3183739280 cites W2135058181 @default.
- W3183739280 cites W2138383542 @default.
- W3183739280 cites W2143580680 @default.
- W3183739280 cites W2144903262 @default.
- W3183739280 cites W2147291569 @default.
- W3183739280 cites W2150862088 @default.
- W3183739280 cites W2151911795 @default.
- W3183739280 cites W2171476379 @default.
- W3183739280 cites W2286498994 @default.
- W3183739280 cites W2537873018 @default.
- W3183739280 cites W2572831163 @default.
- W3183739280 cites W2608042896 @default.
- W3183739280 cites W2747080541 @default.
- W3183739280 cites W2767526093 @default.
- W3183739280 cites W2771193451 @default.
- W3183739280 cites W2784949616 @default.
- W3183739280 cites W2800473549 @default.
- W3183739280 cites W2807159917 @default.
- W3183739280 cites W2809643018 @default.
- W3183739280 cites W2888672154 @default.
- W3183739280 cites W2889670243 @default.
- W3183739280 cites W2891119826 @default.
- W3183739280 cites W2894397394 @default.
- W3183739280 cites W2896953490 @default.
- W3183739280 cites W2902609075 @default.
- W3183739280 cites W2902947740 @default.
- W3183739280 cites W2906052725 @default.
- W3183739280 cites W2909909804 @default.
- W3183739280 cites W2941930792 @default.
- W3183739280 cites W2992279035 @default.
- W3183739280 cites W3011350719 @default.
- W3183739280 cites W3016787401 @default.
- W3183739280 cites W3026014260 @default.
- W3183739280 cites W3043169190 @default.
- W3183739280 cites W3081291507 @default.
- W3183739280 doi "https://doi.org/10.1371/journal.ppat.1009764" @default.
- W3183739280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8336821" @default.
- W3183739280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34297745" @default.
- W3183739280 hasPublicationYear "2021" @default.
- W3183739280 type Work @default.
- W3183739280 sameAs 3183739280 @default.
- W3183739280 citedByCount "4" @default.
- W3183739280 countsByYear W31837392802022 @default.
- W3183739280 countsByYear W31837392802023 @default.
- W3183739280 crossrefType "journal-article" @default.
- W3183739280 hasAuthorship W3183739280A5005192531 @default.
- W3183739280 hasAuthorship W3183739280A5021843274 @default.
- W3183739280 hasAuthorship W3183739280A5022408570 @default.
- W3183739280 hasAuthorship W3183739280A5031062133 @default.
- W3183739280 hasAuthorship W3183739280A5051862250 @default.
- W3183739280 hasAuthorship W3183739280A5060287743 @default.