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- W3183750622 abstract "Sudden cardiac arrest is most often due to ventricular fibrillation (VF). When no cause is found during diagnostic follow-up, fibrillation is classified as idiopathic VF. We hypothesize that subtle repolarization abnormalities may predispose to idiopathic VF, but cannot be detected from the 12-lead electrocardiogram (ECG). To study the presence of repolarization time (RT) gradients in patients with idiopathic VF using the 12-lead ECG and noninvasive electrocardiographic imaging (ECGI). In control individuals without cardiovascular disease and in survivors of idiopathic VF, we manually determined the heart-rate corrected QT interval (QTc) and the interval from peak-to-end of the T wave (Tp-Te) from the 12-lead ECG. ECGI was performed with a custom-made setup to noninvasively map RT isochrones on the epicardium and determine the maximum local RT gradient (RTG). We included 10 control individuals and 11 survivors of idiopathic VF (iVF). Figure 1 shows that both QTc and Tp-Te from the 12-lead ECG did not differ between these groups. However, ECGI uncovered steeper maximum RT gradients in survivors of idiopathic VF compared to controls (P=0.03). Noninvasive ECGI, but not the standard 12-lead ECG, can uncover RT abnormalities in survivors of idiopathic VF. Steeper RT gradients could play a role in the induction of VF through unidirectional conduction block. Noninvasive ECGI may improve the mechanistic understanding and risk assessment of patients with apparently idiopathic VF." @default.
- W3183750622 created "2021-08-02" @default.
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- W3183750622 date "2021-08-01" @default.
- W3183750622 modified "2023-09-25" @default.
- W3183750622 title "B-PO04-153 SUBTLE REPOLARIZATION ABNORMALITIES IN IDIOPATHIC VENTRICULAR FIBRILLATION ARE UNCOVERED BY NONINVASIVE ELECTROCARDIOGRAPHIC IMAGING, BUT NOT THE 12-LEAD ELECTROCARDIOGRAM" @default.
- W3183750622 doi "https://doi.org/10.1016/j.hrthm.2021.06.845" @default.
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