Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183821444> ?p ?o ?g. }
- W3183821444 abstract "Changed dietary habits in Western countries such as reduced fiber intake represent an important lifestyle factor contributing to the increase in inflammatory immune-mediated diseases. The mode of action of beneficial fiber effects is not fully elucidated, but short-chain fatty acids (SCFA) and gut microbiota have been implicated. The aim of this study was to explore the impact of dietary fiber on lupus pathology and to understand underlying mechanisms. Here, we show that in lupus-prone NZB/WF1 mice low fiber intake deteriorates disease progression reflected in accelerated mortality, autoantibody production and immune dysregulation. In contrast to our original assumption, microbiota suppression by antibiotics or direct SCFA feeding did not influence the course of lupus-like disease. Mechanistically, our data rather indicate that in low fiber-fed mice, an increase in white adipose tissue mass, fat-inflammation and a disrupted intestinal homeostasis go along with systemic, low-grade inflammation driving autoimmunity. The links between obesity, intestinal leakage and low-grade inflammation were confirmed in human samples, while adaptive immune activation predominantly correlated with lupus activity. We further propose that an accelerated gastro-intestinal passage along with energy dilution underlies fiber-mediated weight regulation. Thus, our data highlight the often-overlooked effects of dietary fiber on energy homeostasis and obesity prevention. Further, they provide insight into how intricately the pathologies of inflammatory immune-mediated conditions, such as obesity and autoimmunity, might be interlinked, possibly sharing common pathways." @default.
- W3183821444 created "2021-08-02" @default.
- W3183821444 creator A5004962774 @default.
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- W3183821444 date "2021-07-15" @default.
- W3183821444 modified "2023-10-06" @default.
- W3183821444 title "Low Dietary Fiber Intake Links Development of Obesity and Lupus Pathogenesis" @default.
- W3183821444 cites W1820319724 @default.
- W3183821444 cites W1910911365 @default.
- W3183821444 cites W1937335458 @default.
- W3183821444 cites W1941562583 @default.
- W3183821444 cites W1957802592 @default.
- W3183821444 cites W1967168258 @default.
- W3183821444 cites W1976611079 @default.
- W3183821444 cites W1989496014 @default.
- W3183821444 cites W1997248937 @default.
- W3183821444 cites W1998313940 @default.
- W3183821444 cites W1999906527 @default.
- W3183821444 cites W2003342633 @default.
- W3183821444 cites W2008993230 @default.
- W3183821444 cites W2009170813 @default.
- W3183821444 cites W2009759079 @default.
- W3183821444 cites W2014024197 @default.
- W3183821444 cites W2025402613 @default.
- W3183821444 cites W2033239478 @default.
- W3183821444 cites W2047092958 @default.
- W3183821444 cites W2048469790 @default.
- W3183821444 cites W2050315287 @default.
- W3183821444 cites W2061179865 @default.
- W3183821444 cites W2065384280 @default.
- W3183821444 cites W2068234766 @default.
- W3183821444 cites W2078455937 @default.
- W3183821444 cites W2079974518 @default.
- W3183821444 cites W2083119809 @default.
- W3183821444 cites W2087278385 @default.
- W3183821444 cites W2087292184 @default.
- W3183821444 cites W2093876680 @default.
- W3183821444 cites W2108887551 @default.
- W3183821444 cites W2116647894 @default.
- W3183821444 cites W2118166675 @default.
- W3183821444 cites W2121900746 @default.
- W3183821444 cites W2125784987 @default.
- W3183821444 cites W2131536322 @default.
- W3183821444 cites W2133010654 @default.
- W3183821444 cites W2138220577 @default.
- W3183821444 cites W2144079797 @default.
- W3183821444 cites W2146488133 @default.
- W3183821444 cites W2147856029 @default.
- W3183821444 cites W2148706075 @default.
- W3183821444 cites W2149515881 @default.
- W3183821444 cites W2157201312 @default.
- W3183821444 cites W2161332823 @default.
- W3183821444 cites W2163144009 @default.
- W3183821444 cites W2166124362 @default.
- W3183821444 cites W2167776875 @default.
- W3183821444 cites W2169970351 @default.
- W3183821444 cites W2236963792 @default.
- W3183821444 cites W2278335898 @default.
- W3183821444 cites W2335805754 @default.
- W3183821444 cites W2391252544 @default.
- W3183821444 cites W2469218097 @default.
- W3183821444 cites W2491805933 @default.
- W3183821444 cites W2510024185 @default.
- W3183821444 cites W2526011394 @default.
- W3183821444 cites W2551404503 @default.
- W3183821444 cites W2552041992 @default.
- W3183821444 cites W2585111741 @default.
- W3183821444 cites W2586155766 @default.
- W3183821444 cites W2589854016 @default.
- W3183821444 cites W2603850261 @default.
- W3183821444 cites W2619685470 @default.
- W3183821444 cites W2620098478 @default.
- W3183821444 cites W2735051210 @default.
- W3183821444 cites W2765210706 @default.
- W3183821444 cites W2774400912 @default.
- W3183821444 cites W2776874704 @default.
- W3183821444 cites W2778082937 @default.
- W3183821444 cites W2780031181 @default.
- W3183821444 cites W2780318474 @default.
- W3183821444 cites W2790159098 @default.
- W3183821444 cites W2792933846 @default.
- W3183821444 cites W2884220996 @default.
- W3183821444 cites W2895975223 @default.
- W3183821444 cites W2905995477 @default.
- W3183821444 cites W2911876060 @default.
- W3183821444 cites W2920402429 @default.
- W3183821444 cites W2922144168 @default.
- W3183821444 cites W2945024048 @default.
- W3183821444 cites W2946483762 @default.