Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183897240> ?p ?o ?g. }
- W3183897240 abstract "Abstract Sweet and umami are respectively elicited by sweet/umami receptor on the tongue and palate epithelium. However, the molecular machinery allowing to taste reaction remains incompletely understood. Through a phosphoproteomic approach, we found the key proteins that trigger taste mechanisms based on the phosphorylation cascades. Thereinto, ryanodine receptor isoform 1 (RYR1) was further verified by sensor and behaviors assay. A model proposing RYR1-mediated sweet/umami signaling: RYR1 channel which mediates Ca 2+ release from the endoplasmic reticulum is closed by its dephosphorylation in the bud tissue after umami/sweet treatment. And the alteration of Ca 2+ content in the cytosol induces a transient membrane depolarization and generates cell current for taste signaling transduction. We demonstrate that RYR1 is a new channel in regulation of sweet/umami signaling transduction and also propose a “metabolic clock” notion based on sweet/umami sensing. Our study provides a rich fundamental for a system-level understanding of taste perception mechanism." @default.
- W3183897240 created "2021-08-02" @default.
- W3183897240 creator A5001979852 @default.
- W3183897240 creator A5025981801 @default.
- W3183897240 creator A5026573236 @default.
- W3183897240 creator A5056288856 @default.
- W3183897240 creator A5063827511 @default.
- W3183897240 creator A5077065722 @default.
- W3183897240 date "2021-07-21" @default.
- W3183897240 modified "2023-09-27" @default.
- W3183897240 title "Remodeling of ryanodine receptor isoform 1 channel regulates the sweet and umami perception of Rattus norvegicus" @default.
- W3183897240 cites W1505725686 @default.
- W3183897240 cites W1563686948 @default.
- W3183897240 cites W1825731665 @default.
- W3183897240 cites W1964468911 @default.
- W3183897240 cites W1971048452 @default.
- W3183897240 cites W1971207325 @default.
- W3183897240 cites W1976766182 @default.
- W3183897240 cites W2013759736 @default.
- W3183897240 cites W2023939486 @default.
- W3183897240 cites W2030827817 @default.
- W3183897240 cites W2038256300 @default.
- W3183897240 cites W2042504416 @default.
- W3183897240 cites W2043794217 @default.
- W3183897240 cites W2047337699 @default.
- W3183897240 cites W2048559246 @default.
- W3183897240 cites W2059587718 @default.
- W3183897240 cites W2064910808 @default.
- W3183897240 cites W2067960353 @default.
- W3183897240 cites W2086339199 @default.
- W3183897240 cites W2111658605 @default.
- W3183897240 cites W2121570525 @default.
- W3183897240 cites W2122060463 @default.
- W3183897240 cites W2126680318 @default.
- W3183897240 cites W2133347001 @default.
- W3183897240 cites W2139337253 @default.
- W3183897240 cites W2157604192 @default.
- W3183897240 cites W2164762131 @default.
- W3183897240 cites W2171083063 @default.
- W3183897240 cites W2312550217 @default.
- W3183897240 cites W2419423106 @default.
- W3183897240 cites W2461652360 @default.
- W3183897240 cites W2584413253 @default.
- W3183897240 cites W2731177171 @default.
- W3183897240 cites W2742748694 @default.
- W3183897240 cites W2742856042 @default.
- W3183897240 cites W2783870236 @default.
- W3183897240 cites W2904336013 @default.
- W3183897240 cites W2914360727 @default.
- W3183897240 cites W2923163401 @default.
- W3183897240 cites W2941082080 @default.
- W3183897240 cites W2951359509 @default.
- W3183897240 cites W2967680344 @default.
- W3183897240 cites W2974814716 @default.
- W3183897240 cites W2981270413 @default.
- W3183897240 cites W2999428292 @default.
- W3183897240 cites W3033156091 @default.
- W3183897240 cites W3040438397 @default.
- W3183897240 cites W3081769550 @default.
- W3183897240 cites W3104815548 @default.
- W3183897240 cites W4249590403 @default.
- W3183897240 doi "https://doi.org/10.1101/2021.07.20.453074" @default.
- W3183897240 hasPublicationYear "2021" @default.
- W3183897240 type Work @default.
- W3183897240 sameAs 3183897240 @default.
- W3183897240 citedByCount "0" @default.
- W3183897240 crossrefType "posted-content" @default.
- W3183897240 hasAuthorship W3183897240A5001979852 @default.
- W3183897240 hasAuthorship W3183897240A5025981801 @default.
- W3183897240 hasAuthorship W3183897240A5026573236 @default.
- W3183897240 hasAuthorship W3183897240A5056288856 @default.
- W3183897240 hasAuthorship W3183897240A5063827511 @default.
- W3183897240 hasAuthorship W3183897240A5077065722 @default.
- W3183897240 hasBestOaLocation W31838972401 @default.
- W3183897240 hasConcept C113217602 @default.
- W3183897240 hasConcept C15152581 @default.
- W3183897240 hasConcept C158617107 @default.
- W3183897240 hasConcept C178006227 @default.
- W3183897240 hasConcept C201571599 @default.
- W3183897240 hasConcept C2776333580 @default.
- W3183897240 hasConcept C2776946002 @default.
- W3183897240 hasConcept C2777687625 @default.
- W3183897240 hasConcept C55493867 @default.
- W3183897240 hasConcept C62478195 @default.
- W3183897240 hasConcept C86803240 @default.
- W3183897240 hasConcept C8868529 @default.
- W3183897240 hasConcept C95444343 @default.
- W3183897240 hasConceptScore W3183897240C113217602 @default.
- W3183897240 hasConceptScore W3183897240C15152581 @default.
- W3183897240 hasConceptScore W3183897240C158617107 @default.
- W3183897240 hasConceptScore W3183897240C178006227 @default.
- W3183897240 hasConceptScore W3183897240C201571599 @default.
- W3183897240 hasConceptScore W3183897240C2776333580 @default.
- W3183897240 hasConceptScore W3183897240C2776946002 @default.
- W3183897240 hasConceptScore W3183897240C2777687625 @default.
- W3183897240 hasConceptScore W3183897240C55493867 @default.
- W3183897240 hasConceptScore W3183897240C62478195 @default.
- W3183897240 hasConceptScore W3183897240C86803240 @default.
- W3183897240 hasConceptScore W3183897240C8868529 @default.
- W3183897240 hasConceptScore W3183897240C95444343 @default.