Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183920134> ?p ?o ?g. }
- W3183920134 endingPage "1848" @default.
- W3183920134 startingPage "1828" @default.
- W3183920134 abstract "Antisense oligonucleotides (ASOs) have the ability of binding to endogenous nucleic acid targets, thereby inhibiting the gene expression. Although ASOs have great potential in the treatment of many diseases, the search for favorable toxicity profiles and distribution has been challenging and consequently impeded the widespread use of ASOs as conventional medicine. One strategy that has been employed to optimize the delivery profile of ASOs, is the functionalization of ASOs with cationic amine groups, either by direct conjugation onto the sugar, nucleobase or internucleotide linkage. The introduction of these positively charged groups has improved properties like nuclease resistance, increased binding to the nucleic acid target and improved cell uptake for oligonucleotides (ONs) and ASOs. The modifications highlighted in this review are some of the most prevalent cationic amine groups which have been attached as single modifications onto ONs/ASOs. The review has been separated into three sections, nucleobase, sugar and backbone modifications, highlighting what impact the cationic amine groups have on the ONs/ASOs physiochemical and biological properties. Finally, a concluding section has been added, summarizing the important knowledge from the three chapters, and examining the future design for ASOs." @default.
- W3183920134 created "2021-08-02" @default.
- W3183920134 creator A5069462201 @default.
- W3183920134 creator A5084599077 @default.
- W3183920134 date "2021-07-29" @default.
- W3183920134 modified "2023-10-17" @default.
- W3183920134 title "Cationic oligonucleotide derivatives and conjugates: A favorable approach for enhanced DNA and RNA targeting oligonucleotides" @default.
- W3183920134 cites W1564730852 @default.
- W3183920134 cites W1908796392 @default.
- W3183920134 cites W1951925524 @default.
- W3183920134 cites W1966503070 @default.
- W3183920134 cites W1966720236 @default.
- W3183920134 cites W1967169532 @default.
- W3183920134 cites W1967769593 @default.
- W3183920134 cites W1970729433 @default.
- W3183920134 cites W1971643509 @default.
- W3183920134 cites W1972015990 @default.
- W3183920134 cites W1972765790 @default.
- W3183920134 cites W1975088062 @default.
- W3183920134 cites W1975292167 @default.
- W3183920134 cites W1977399578 @default.
- W3183920134 cites W1977911233 @default.
- W3183920134 cites W1980255172 @default.
- W3183920134 cites W1985092408 @default.
- W3183920134 cites W1986578401 @default.
- W3183920134 cites W2005894581 @default.
- W3183920134 cites W2006646827 @default.
- W3183920134 cites W2008128810 @default.
- W3183920134 cites W2009288509 @default.
- W3183920134 cites W2009941716 @default.
- W3183920134 cites W2011234219 @default.
- W3183920134 cites W2015014732 @default.
- W3183920134 cites W2017112907 @default.
- W3183920134 cites W2017642141 @default.
- W3183920134 cites W2018328995 @default.
- W3183920134 cites W2020211756 @default.
- W3183920134 cites W2020944801 @default.
- W3183920134 cites W2021492610 @default.
- W3183920134 cites W2025350111 @default.
- W3183920134 cites W2026749527 @default.
- W3183920134 cites W2027384914 @default.
- W3183920134 cites W2029795321 @default.
- W3183920134 cites W2031410480 @default.
- W3183920134 cites W2036149754 @default.
- W3183920134 cites W2038497677 @default.
- W3183920134 cites W2038911410 @default.
- W3183920134 cites W2039801211 @default.
- W3183920134 cites W2040854155 @default.
- W3183920134 cites W2041012398 @default.
- W3183920134 cites W2043116561 @default.
- W3183920134 cites W2044395210 @default.
- W3183920134 cites W2045020949 @default.
- W3183920134 cites W2045535684 @default.
- W3183920134 cites W2046295524 @default.
- W3183920134 cites W2049247207 @default.
- W3183920134 cites W2051263218 @default.
- W3183920134 cites W2055126689 @default.
- W3183920134 cites W2059116209 @default.
- W3183920134 cites W2063375627 @default.
- W3183920134 cites W2064761203 @default.
- W3183920134 cites W2065470804 @default.
- W3183920134 cites W2065678782 @default.
- W3183920134 cites W2065827607 @default.
- W3183920134 cites W2065841614 @default.
- W3183920134 cites W2066004189 @default.
- W3183920134 cites W2066495656 @default.
- W3183920134 cites W2067287046 @default.
- W3183920134 cites W2072384785 @default.
- W3183920134 cites W2073852432 @default.
- W3183920134 cites W2077085904 @default.
- W3183920134 cites W2079550164 @default.
- W3183920134 cites W2079628658 @default.
- W3183920134 cites W2080660363 @default.
- W3183920134 cites W2081228790 @default.
- W3183920134 cites W2082207780 @default.
- W3183920134 cites W2086328546 @default.
- W3183920134 cites W2089582926 @default.
- W3183920134 cites W2091406831 @default.
- W3183920134 cites W2094679684 @default.
- W3183920134 cites W2108697752 @default.
- W3183920134 cites W2113657260 @default.
- W3183920134 cites W2113911414 @default.
- W3183920134 cites W2118601234 @default.
- W3183920134 cites W2124443849 @default.
- W3183920134 cites W2125899815 @default.
- W3183920134 cites W2128456046 @default.
- W3183920134 cites W2129364859 @default.
- W3183920134 cites W2132050155 @default.
- W3183920134 cites W2138533167 @default.
- W3183920134 cites W2138788692 @default.
- W3183920134 cites W2139147931 @default.
- W3183920134 cites W2147777616 @default.
- W3183920134 cites W2149681664 @default.
- W3183920134 cites W2152778335 @default.
- W3183920134 cites W2153175562 @default.
- W3183920134 cites W2153733668 @default.
- W3183920134 cites W2157287222 @default.
- W3183920134 cites W2164903159 @default.