FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183928388> ?p ?o ?g. }

• W3183928388 abstract "The use of circulating tumor DNA (ctDNA) to reflect clinical benefits of advanced non-small cell lung cancer (NSCLC) patients during immune checkpoint inhibitor (ICI) therapy remains controversial. This study aimed to determine the association of pre-treatment and early dynamic changes of ctDNA with clinical outcomes in advanced NSCLC patients treated with ICIs.Electronic databases (PubMed, Embase, Web of Science, and Cochrane) were systematically searched to include relevant studies published in English up to November 2020. The primary outcomes were overall survival (OS) and progression-free survival (PFS) and the secondary outcome was objective response rate (ORR) with RECIST criteria.A total of 1017 patients from 10 studies were identified. The baseline ctDNA levels (detected versus not detected) showed no significant association with clinical outcomes regarding OS (hazard ratio [HR], 1.18; 95% confidence interval [CI], 0.93-1.51), PFS (HR, 0.98; 95% CI, 0.80-1.21), and ORR (odds ratio [OR], 0.89; 95% CI, 0.54-1.46). Interestingly, when taken early longitudinal assessment of ctDNA into consideration, the early reduction of the concentration of ctDNA was associated with significant improvements of OS (HR, 0.19; 95% CI, 0.10-0.35), PFS (HR, 0.30; 95% CI, 0.22-0.41) and ORR (OR, 0.07; 95% CI, 0.03-0.18). Further subgroup analyses revealed that the reduction magnitude did not significantly impact the association between ctDNA and clinical outcomes, suggesting that both patients with decreased ctDNA or a ≥50% reduction of ctDNA was associated with improved OS, PFS and ORR.Early reduction of ctDNA was associated with improved OS, PFS and ORR in advanced NSCLC patients treated with ICIs.https://www.crd.york.ac.uk/PROSPERO, CRD42021226255." @default.
• W3183928388 created "2021-08-02" @default.
• W3183928388 creator A5006613618 @default.
• W3183928388 creator A5008421599 @default.
• W3183928388 creator A5021941803 @default.
• W3183928388 creator A5029068742 @default.
• W3183928388 creator A5030449789 @default.
• W3183928388 creator A5055029433 @default.
• W3183928388 creator A5081855304 @default.
• W3183928388 date "2021-07-21" @default.
• W3183928388 modified "2023-10-18" @default.
• W3183928388 title "The Role of Circulating Tumor DNA in Advanced Non-Small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis" @default.
• W3183928388 cites W1967046314 @default.
• W3183928388 cites W1982836389 @default.
• W3183928388 cites W1983466841 @default.
• W3183928388 cites W1985823023 @default.
• W3183928388 cites W1989498651 @default.
• W3183928388 cites W2007872832 @default.
• W3183928388 cites W2041998362 @default.
• W3183928388 cites W2073195024 @default.
• W3183928388 cites W2076466060 @default.
• W3183928388 cites W2088095316 @default.
• W3183928388 cites W2090005550 @default.
• W3183928388 cites W2120869188 @default.
• W3183928388 cites W2140575188 @default.
• W3183928388 cites W2167806838 @default.
• W3183928388 cites W2171237493 @default.
• W3183928388 cites W2174280796 @default.
• W3183928388 cites W2191042712 @default.
• W3183928388 cites W2206684187 @default.
• W3183928388 cites W2294395959 @default.
• W3183928388 cites W2328294134 @default.
• W3183928388 cites W2337664219 @default.
• W3183928388 cites W2425479000 @default.
• W3183928388 cites W2473218705 @default.
• W3183928388 cites W2498387096 @default.
• W3183928388 cites W2561358247 @default.
• W3183928388 cites W2561459036 @default.
• W3183928388 cites W2581111720 @default.
• W3183928388 cites W2587048937 @default.
• W3183928388 cites W2588078993 @default.
• W3183928388 cites W2601621622 @default.
• W3183928388 cites W2605385750 @default.
• W3183928388 cites W2607977201 @default.
• W3183928388 cites W2745259295 @default.
• W3183928388 cites W2766399158 @default.
• W3183928388 cites W2783576981 @default.
• W3183928388 cites W2807519281 @default.
• W3183928388 cites W2809015861 @default.
• W3183928388 cites W2883787611 @default.
• W3183928388 cites W2886963239 @default.
• W3183928388 cites W2898037973 @default.
• W3183928388 cites W2902173562 @default.
• W3183928388 cites W2905051664 @default.
• W3183928388 cites W2907564726 @default.
• W3183928388 cites W2917102036 @default.
• W3183928388 cites W2945616121 @default.
• W3183928388 cites W2972179964 @default.
• W3183928388 cites W2990870977 @default.
• W3183928388 cites W2996038327 @default.
• W3183928388 cites W3014048998 @default.
• W3183928388 cites W3021923951 @default.
• W3183928388 cites W3036135178 @default.
• W3183928388 cites W3049083268 @default.
• W3183928388 cites W3083211100 @default.
• W3183928388 cites W3090649019 @default.
• W3183928388 cites W3091425478 @default.
• W3183928388 cites W3094177321 @default.
• W3183928388 cites W3100650313 @default.
• W3183928388 cites W3102224823 @default.
• W3183928388 cites W4235642752 @default.
• W3183928388 doi "https://doi.org/10.3389/fonc.2021.671874" @default.
• W3183928388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8335591" @default.
• W3183928388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34367957" @default.
• W3183928388 hasPublicationYear "2021" @default.
• W3183928388 type Work @default.
• W3183928388 sameAs 3183928388 @default.
• W3183928388 citedByCount "11" @default.
• W3183928388 countsByYear W31839283882022 @default.
• W3183928388 countsByYear W31839283882023 @default.
• W3183928388 crossrefType "journal-article" @default.
• W3183928388 hasAuthorship W3183928388A5006613618 @default.
• W3183928388 hasAuthorship W3183928388A5008421599 @default.
• W3183928388 hasAuthorship W3183928388A5021941803 @default.
• W3183928388 hasAuthorship W3183928388A5029068742 @default.
• W3183928388 hasAuthorship W3183928388A5030449789 @default.
• W3183928388 hasAuthorship W3183928388A5055029433 @default.
• W3183928388 hasAuthorship W3183928388A5081855304 @default.
• W3183928388 hasBestOaLocation W31839283881 @default.
• W3183928388 hasConcept C121608353 @default.
• W3183928388 hasConcept C126322002 @default.
• W3183928388 hasConcept C143998085 @default.
• W3183928388 hasConcept C156957248 @default.
• W3183928388 hasConcept C187960798 @default.
• W3183928388 hasConcept C207103383 @default.
• W3183928388 hasConcept C2776256026 @default.
• W3183928388 hasConcept C2779984678 @default.
• W3183928388 hasConcept C2781335228 @default.
• W3183928388 hasConcept C31760486 @default.
• W3183928388 hasConcept C44249647 @default.

• next