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• W3183945072 abstract "Sequence-dependent off-target effects are a serious problem of antisense oligonucleotide-based drugs. Some of these side effects are induced by ribonuclease H (RNase H)-mediated cleavage of non-target RNAs with base sequences similar to that of the target RNA. We found that an artificial cationic oligosaccharide, ODAGal4, improved single-base discrimination for RNase H cleavage." @default.
• W3183945072 created "2021-08-02" @default.
• W3183945072 creator A5059943171 @default.
• W3183945072 creator A5063456195 @default.
• W3183945072 date "2021-01-01" @default.
• W3183945072 modified "2023-09-24" @default.
• W3183945072 title "Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide" @default.
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• W3183945072 doi "https://doi.org/10.1039/d1ob00983d" @default.
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