FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3183996874> ?p ?o ?g. }

• W3183996874 endingPage "908.e11" @default.
• W3183996874 startingPage "908.e1" @default.
• W3183996874 abstract "Pretreatment before transplantation initiates an inflammatory response. Inflammasomes are key regulators of immune and inflammatory responses, but their role in regulating hematopoiesis is unclear. Our study intended to assess the role and mechanism of nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) in the bone marrow microenvironment on hematopoiesis regulation. To explore the effects of an absence of NLRP1 on hematopoietic reconstitution, we established a hematopoietic cell transplantation model by infusing bone marrow mononuclear cells of wild-type C57BL/6 mice into either NLRP1 knockout (NLRP1-KO) or wild-type C57BL/6 mice. Using the transplantation model, the role of NLRP1 in the bone marrow microenvironment was determined by flow cytometry, hemacytometry, and hematoxylin and eosin staining. As the major component of the bone marrow microenvironment, mesenchymal stem cells (MSCs) were isolated to analyze the effects of NLRP1 on them by osteogenic and adipogenic induction. Endothelial cells (ECs) were isolated and sorted by magnetic beads. The expression of adhesion molecules and their relationship with nuclear factor kappa B (NF-κB) were measured by immunofluorescence, enzyme-linked immunosorbent assay, and western blot. Finally, the effect of NLRP1-deleted MSCs or ECs on hematopoietic stem and progenitor cells (HSPCs) was examined by establishing co-culture models. Compared with C57BL/6 recipients, reduced inflammatory cell infiltration, decreased levels of proinflammatory cytokines interleukin (IL)-18, IL-1β, IL-6, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ), together with reduced pathological injury of bone marrow, were observed in NLRP1-KO recipients after transplantation. However, increased HSPC engraftment and hematopoietic reconstitution were detected in NLRP1-KO recipients after transplantation. Furthermore, MSCs isolated from NLRP1-KO mice had decreased osteogenic and adipogenic differentiation and increased proliferation and differentiation of HSPCs. The expression of adhesion molecules in ECs from NLRP1-KO mice was increased due to the promotion of nuclear translocation of NF-κB; these adhesion molecules are critical for hematopoietic stem cell homing. Knockout of NLRP1 in the bone marrow microenvironment could significantly relieve bone marrow inflammatory response and promote hematopoietic reconstitution, perhaps by regulating MSCs and ECs, indicating that NLRP1 might be a target for the treatment of delayed hematopoietic and immune recovery in patients after hematopoietic stem cell transplantation." @default.
• W3183996874 created "2021-08-02" @default.
• W3183996874 creator A5012246103 @default.
• W3183996874 creator A5019529285 @default.
• W3183996874 creator A5032808067 @default.
• W3183996874 creator A5039085303 @default.
• W3183996874 creator A5040655018 @default.
• W3183996874 creator A5043228704 @default.
• W3183996874 creator A5056724088 @default.
• W3183996874 creator A5061053623 @default.
• W3183996874 creator A5073452348 @default.
• W3183996874 creator A5091166192 @default.
• W3183996874 date "2021-11-01" @default.
• W3183996874 modified "2023-09-23" @default.
• W3183996874 title "NLRP1 in Bone Marrow Microenvironment Controls Hematopoietic Reconstitution After Transplantation" @default.
• W3183996874 cites W1782909963 @default.
• W3183996874 cites W1989289468 @default.
• W3183996874 cites W1991817150 @default.
• W3183996874 cites W1992359197 @default.
• W3183996874 cites W2005718040 @default.
• W3183996874 cites W2019524333 @default.
• W3183996874 cites W2038920846 @default.
• W3183996874 cites W2041357218 @default.
• W3183996874 cites W2041624512 @default.
• W3183996874 cites W2049016944 @default.
• W3183996874 cites W2149053153 @default.
• W3183996874 cites W2156301166 @default.
• W3183996874 cites W2169023984 @default.
• W3183996874 cites W2178218125 @default.
• W3183996874 cites W2342621908 @default.
• W3183996874 cites W2343868815 @default.
• W3183996874 cites W2548884024 @default.
• W3183996874 cites W2557663424 @default.
• W3183996874 cites W2597992859 @default.
• W3183996874 cites W2625712295 @default.
• W3183996874 cites W2741709771 @default.
• W3183996874 cites W2801477130 @default.
• W3183996874 cites W2803941007 @default.
• W3183996874 cites W2804526894 @default.
• W3183996874 cites W2872234724 @default.
• W3183996874 cites W2898197009 @default.
• W3183996874 cites W3112902030 @default.
• W3183996874 doi "https://doi.org/10.1016/j.jtct.2021.07.016" @default.
• W3183996874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34303016" @default.
• W3183996874 hasPublicationYear "2021" @default.
• W3183996874 type Work @default.
• W3183996874 sameAs 3183996874 @default.
• W3183996874 citedByCount "2" @default.
• W3183996874 countsByYear W31839968742022 @default.
• W3183996874 crossrefType "journal-article" @default.
• W3183996874 hasAuthorship W3183996874A5012246103 @default.
• W3183996874 hasAuthorship W3183996874A5019529285 @default.
• W3183996874 hasAuthorship W3183996874A5032808067 @default.
• W3183996874 hasAuthorship W3183996874A5039085303 @default.
• W3183996874 hasAuthorship W3183996874A5040655018 @default.
• W3183996874 hasAuthorship W3183996874A5043228704 @default.
• W3183996874 hasAuthorship W3183996874A5056724088 @default.
• W3183996874 hasAuthorship W3183996874A5061053623 @default.
• W3183996874 hasAuthorship W3183996874A5073452348 @default.
• W3183996874 hasAuthorship W3183996874A5091166192 @default.
• W3183996874 hasBestOaLocation W31839968741 @default.
• W3183996874 hasConcept C109159458 @default.
• W3183996874 hasConcept C126322002 @default.
• W3183996874 hasConcept C142724271 @default.
• W3183996874 hasConcept C164027704 @default.
• W3183996874 hasConcept C198826908 @default.
• W3183996874 hasConcept C203014093 @default.
• W3183996874 hasConcept C2776914184 @default.
• W3183996874 hasConcept C2777209026 @default.
• W3183996874 hasConcept C2780007613 @default.
• W3183996874 hasConcept C28328180 @default.
• W3183996874 hasConcept C2911091166 @default.
• W3183996874 hasConcept C502942594 @default.
• W3183996874 hasConcept C71924100 @default.
• W3183996874 hasConcept C86803240 @default.
• W3183996874 hasConcept C95444343 @default.
• W3183996874 hasConceptScore W3183996874C109159458 @default.
• W3183996874 hasConceptScore W3183996874C126322002 @default.
• W3183996874 hasConceptScore W3183996874C142724271 @default.
• W3183996874 hasConceptScore W3183996874C164027704 @default.
• W3183996874 hasConceptScore W3183996874C198826908 @default.
• W3183996874 hasConceptScore W3183996874C203014093 @default.
• W3183996874 hasConceptScore W3183996874C2776914184 @default.
• W3183996874 hasConceptScore W3183996874C2777209026 @default.
• W3183996874 hasConceptScore W3183996874C2780007613 @default.
• W3183996874 hasConceptScore W3183996874C28328180 @default.
• W3183996874 hasConceptScore W3183996874C2911091166 @default.
• W3183996874 hasConceptScore W3183996874C502942594 @default.
• W3183996874 hasConceptScore W3183996874C71924100 @default.
• W3183996874 hasConceptScore W3183996874C86803240 @default.
• W3183996874 hasConceptScore W3183996874C95444343 @default.
• W3183996874 hasIssue "11" @default.
• W3183996874 hasLocation W31839968741 @default.
• W3183996874 hasLocation W31839968742 @default.
• W3183996874 hasOpenAccess W3183996874 @default.
• W3183996874 hasPrimaryLocation W31839968741 @default.
• W3183996874 hasRelatedWork W1978598034 @default.
• W3183996874 hasRelatedWork W2036108155 @default.

• next