Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184120717> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W3184120717 endingPage "S372" @default.
- W3184120717 startingPage "S372" @default.
- W3184120717 abstract "Pulsed electric field (PEF) therapy kills cells in targeted tissues via mechanisms dependent on local field effects, where different tissue layers will distort this distribution. Numerically evaluate the implications of the heterogeneous electrical conductivity tissues surrounding cardiac ablation sites on the spatial distribution of PEF ablation effects. A numerical model was created using human CT images and well-established tissue conductivity parameters to estimate the thoracic electric field and current distributions from a focal monopolar electrode delivering PEF to the endocardium. Electrically heterogeneous environments surrounding cardiac ablation sites affects the spatial distribution of the electric field and current flow during PEF. Discontinuities of conductivity at tissue planes have a dispersive effect on the strength of the field with the most significant diminution of field strength occurring immediately adjacent to the myocardium at the high-impedance fibrous pericardium. These results indicate a protective effect from the heterogeneous tissue layers in the thoracic environment, reducing electric field exposures to extra-cardiac tissues. The pericardial fluid-sac system disperses and insulates the electric current from reaching critical structures in the extra-cardiac environment. The electrically heterogeneous tissue layers surrounding the heart provide a protective effect to adjacent tissue during the application of PEF. These data support previously described preclinical and clinical findings of spared sensitive tissues, including esophagus, following PEF therapy." @default.
- W3184120717 created "2021-08-02" @default.
- W3184120717 creator A5003371643 @default.
- W3184120717 date "2021-08-01" @default.
- W3184120717 modified "2023-09-25" @default.
- W3184120717 title "B-PO05-004 THE INFLUENCE OF HETEROGENEOUS ENVIRONMENTS ON PULSED ELECTRIC FIELD THERAPY EFFECTS: IMPLICATIONS IN CARDIAC ABLATION" @default.
- W3184120717 doi "https://doi.org/10.1016/j.hrthm.2021.06.924" @default.
- W3184120717 hasPublicationYear "2021" @default.
- W3184120717 type Work @default.
- W3184120717 sameAs 3184120717 @default.
- W3184120717 citedByCount "0" @default.
- W3184120717 crossrefType "journal-article" @default.
- W3184120717 hasAuthorship W3184120717A5003371643 @default.
- W3184120717 hasConcept C119599485 @default.
- W3184120717 hasConcept C121332964 @default.
- W3184120717 hasConcept C127413603 @default.
- W3184120717 hasConcept C136229726 @default.
- W3184120717 hasConcept C164705383 @default.
- W3184120717 hasConcept C192562407 @default.
- W3184120717 hasConcept C2778875491 @default.
- W3184120717 hasConcept C2778902805 @default.
- W3184120717 hasConcept C60799052 @default.
- W3184120717 hasConcept C62520636 @default.
- W3184120717 hasConcept C69990965 @default.
- W3184120717 hasConcept C71924100 @default.
- W3184120717 hasConcept C85378888 @default.
- W3184120717 hasConceptScore W3184120717C119599485 @default.
- W3184120717 hasConceptScore W3184120717C121332964 @default.
- W3184120717 hasConceptScore W3184120717C127413603 @default.
- W3184120717 hasConceptScore W3184120717C136229726 @default.
- W3184120717 hasConceptScore W3184120717C164705383 @default.
- W3184120717 hasConceptScore W3184120717C192562407 @default.
- W3184120717 hasConceptScore W3184120717C2778875491 @default.
- W3184120717 hasConceptScore W3184120717C2778902805 @default.
- W3184120717 hasConceptScore W3184120717C60799052 @default.
- W3184120717 hasConceptScore W3184120717C62520636 @default.
- W3184120717 hasConceptScore W3184120717C69990965 @default.
- W3184120717 hasConceptScore W3184120717C71924100 @default.
- W3184120717 hasConceptScore W3184120717C85378888 @default.
- W3184120717 hasIssue "8" @default.
- W3184120717 hasLocation W31841207171 @default.
- W3184120717 hasOpenAccess W3184120717 @default.
- W3184120717 hasPrimaryLocation W31841207171 @default.
- W3184120717 hasRelatedWork W1971848597 @default.
- W3184120717 hasRelatedWork W1996629538 @default.
- W3184120717 hasRelatedWork W2062765830 @default.
- W3184120717 hasRelatedWork W2103683515 @default.
- W3184120717 hasRelatedWork W2105871333 @default.
- W3184120717 hasRelatedWork W2157222971 @default.
- W3184120717 hasRelatedWork W2395369037 @default.
- W3184120717 hasRelatedWork W2899084033 @default.
- W3184120717 hasRelatedWork W4253634486 @default.
- W3184120717 hasRelatedWork W4280534903 @default.
- W3184120717 hasVolume "18" @default.
- W3184120717 isParatext "false" @default.
- W3184120717 isRetracted "false" @default.
- W3184120717 magId "3184120717" @default.
- W3184120717 workType "article" @default.