Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184156133> ?p ?o ?g. }
- W3184156133 endingPage "10998" @default.
- W3184156133 startingPage "10990" @default.
- W3184156133 abstract "The detection and unambiguous identification of anabolic-androgenic steroid metabolites are essential in clinical, forensic, and antidoping analyses. Recently, sulfate phase II steroid metabolites have received increased attention in steroid metabolism and drug testing. In large part, this is because phase II steroid metabolites are excreted for an extended time, making them a potential long-term chemical marker of choice for tracking steroid misuse in sports. Comprehensive analytical methods, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), have been used to detect and identify glucuronide and sulfate steroids in human urine with high sensitivity and reliability. However, LC-MS/MS identification strategies can be hindered by the fact that phase II steroid metabolites generate nonselective ion fragments across the different metabolite markers, limiting the confidence in metabolite identifications that rely on exact mass measurement and MS/MS information. Additionally, liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is sometimes insufficient at fully resolving the analyte peaks from the sample matrix (commonly urine) chemical noise, further complicating accurate identification efforts. Therefore, we developed a liquid chromatography-ion mobility-high resolution mass spectrometry (LC-IM-HRMS) method to increase the peak capacity and utilize the IM-derived collision cross section (CCS) values as an additional molecular descriptor for increased selectivity and to improve identifications of intact steroid analyses at low concentrations." @default.
- W3184156133 created "2021-08-02" @default.
- W3184156133 creator A5005697074 @default.
- W3184156133 creator A5009123312 @default.
- W3184156133 creator A5015284543 @default.
- W3184156133 creator A5029537893 @default.
- W3184156133 creator A5036228441 @default.
- W3184156133 creator A5060979905 @default.
- W3184156133 creator A5068370145 @default.
- W3184156133 creator A5083479918 @default.
- W3184156133 date "2021-07-28" @default.
- W3184156133 modified "2023-10-16" @default.
- W3184156133 title "Multidimensional Separations of Intact Phase II Steroid Metabolites Utilizing LC–Ion Mobility–HRMS" @default.
- W3184156133 cites W1971097535 @default.
- W3184156133 cites W1989611687 @default.
- W3184156133 cites W1997852068 @default.
- W3184156133 cites W1998953778 @default.
- W3184156133 cites W2010975099 @default.
- W3184156133 cites W2017026684 @default.
- W3184156133 cites W2027349929 @default.
- W3184156133 cites W2050155533 @default.
- W3184156133 cites W2054074856 @default.
- W3184156133 cites W2058103122 @default.
- W3184156133 cites W2058906815 @default.
- W3184156133 cites W2062001603 @default.
- W3184156133 cites W2063260461 @default.
- W3184156133 cites W2074551825 @default.
- W3184156133 cites W2084596668 @default.
- W3184156133 cites W2100398878 @default.
- W3184156133 cites W2115588498 @default.
- W3184156133 cites W2135378461 @default.
- W3184156133 cites W2136489725 @default.
- W3184156133 cites W2141091417 @default.
- W3184156133 cites W2145687065 @default.
- W3184156133 cites W2162219833 @default.
- W3184156133 cites W2173802463 @default.
- W3184156133 cites W2181856310 @default.
- W3184156133 cites W2196860420 @default.
- W3184156133 cites W2203659294 @default.
- W3184156133 cites W2237134196 @default.
- W3184156133 cites W2256723266 @default.
- W3184156133 cites W2260376334 @default.
- W3184156133 cites W2267802736 @default.
- W3184156133 cites W2293801117 @default.
- W3184156133 cites W2307676457 @default.
- W3184156133 cites W2343625457 @default.
- W3184156133 cites W2429298597 @default.
- W3184156133 cites W2443270994 @default.
- W3184156133 cites W2472541465 @default.
- W3184156133 cites W2507869595 @default.
- W3184156133 cites W2510495376 @default.
- W3184156133 cites W2520784563 @default.
- W3184156133 cites W2528890110 @default.
- W3184156133 cites W2549913218 @default.
- W3184156133 cites W2556411499 @default.
- W3184156133 cites W2558210375 @default.
- W3184156133 cites W2565586364 @default.
- W3184156133 cites W2592707037 @default.
- W3184156133 cites W2740265172 @default.
- W3184156133 cites W2740977550 @default.
- W3184156133 cites W2766139085 @default.
- W3184156133 cites W2766334936 @default.
- W3184156133 cites W2769318746 @default.
- W3184156133 cites W2770555117 @default.
- W3184156133 cites W2771100922 @default.
- W3184156133 cites W2783500810 @default.
- W3184156133 cites W2787526312 @default.
- W3184156133 cites W2789575632 @default.
- W3184156133 cites W2790354264 @default.
- W3184156133 cites W2791620498 @default.
- W3184156133 cites W2792173082 @default.
- W3184156133 cites W2792949919 @default.
- W3184156133 cites W2804224478 @default.
- W3184156133 cites W2900639329 @default.
- W3184156133 cites W2902734986 @default.
- W3184156133 cites W2911888333 @default.
- W3184156133 cites W2913182573 @default.
- W3184156133 cites W2916516578 @default.
- W3184156133 cites W2925495008 @default.
- W3184156133 cites W2935456378 @default.
- W3184156133 cites W2939918800 @default.
- W3184156133 cites W2939937676 @default.
- W3184156133 cites W2940738169 @default.
- W3184156133 cites W2941118932 @default.
- W3184156133 cites W2947791494 @default.
- W3184156133 cites W2972008302 @default.
- W3184156133 cites W2979092268 @default.
- W3184156133 cites W2980875658 @default.
- W3184156133 cites W2997617852 @default.
- W3184156133 cites W2999560238 @default.
- W3184156133 cites W3005159206 @default.
- W3184156133 cites W3007062778 @default.
- W3184156133 cites W3012294650 @default.
- W3184156133 cites W3023609152 @default.
- W3184156133 cites W3025471235 @default.
- W3184156133 cites W3039241810 @default.
- W3184156133 cites W3040201078 @default.
- W3184156133 cites W3081519731 @default.