Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184186616> ?p ?o ?g. }
- W3184186616 abstract "Mitochondrial biogenesis and function are controlled by anterograde regulatory pathways involving more than 1000 nuclear-encoded proteins. Transcriptional networks controlling the nuclear-encoded mitochondrial genes remain to be fully elucidated. Here, we show that histone demethylase LSD1 KO from adult mouse liver (LSD1-LKO) reduces the expression of one-third of all nuclear-encoded mitochondrial genes and decreases mitochondrial biogenesis and function. LSD1-modulated histone methylation epigenetically regulates nuclear-encoded mitochondrial genes. Furthermore, LSD1 regulates gene expression and protein methylation of nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1), which controls the final step of NAD+ synthesis and limits NAD+ availability in the nucleus. Lsd1 KO reduces NAD+-dependent SIRT1 and SIRT7 deacetylase activity, leading to hyperacetylation and hypofunctioning of GABPβ and PGC-1α, the major transcriptional factor/cofactor for nuclear-encoded mitochondrial genes. Despite the reduced mitochondrial function in the liver, LSD1-LKO mice are protected from diet-induced hepatic steatosis and glucose intolerance, partially due to induction of hepatokine FGF21. Thus, LSD1 orchestrates a core regulatory network involving epigenetic modifications and NAD+ synthesis to control mitochondrial function and hepatokine production." @default.
- W3184186616 created "2021-08-02" @default.
- W3184186616 creator A5002156253 @default.
- W3184186616 creator A5003593504 @default.
- W3184186616 creator A5003638009 @default.
- W3184186616 creator A5007947465 @default.
- W3184186616 creator A5020478268 @default.
- W3184186616 creator A5021519984 @default.
- W3184186616 creator A5022121149 @default.
- W3184186616 creator A5027658524 @default.
- W3184186616 creator A5033831242 @default.
- W3184186616 creator A5038056101 @default.
- W3184186616 creator A5043183177 @default.
- W3184186616 creator A5047469346 @default.
- W3184186616 creator A5049968522 @default.
- W3184186616 creator A5051299945 @default.
- W3184186616 creator A5058257133 @default.
- W3184186616 creator A5070754234 @default.
- W3184186616 creator A5074829260 @default.
- W3184186616 creator A5077273869 @default.
- W3184186616 creator A5081690289 @default.
- W3184186616 creator A5084712535 @default.
- W3184186616 creator A5087236600 @default.
- W3184186616 date "2021-09-08" @default.
- W3184186616 modified "2023-10-01" @default.
- W3184186616 title "Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1" @default.
- W3184186616 cites W1503760388 @default.
- W3184186616 cites W1563801633 @default.
- W3184186616 cites W1607452049 @default.
- W3184186616 cites W1640068223 @default.
- W3184186616 cites W1717419206 @default.
- W3184186616 cites W1959721425 @default.
- W3184186616 cites W1968352614 @default.
- W3184186616 cites W1971082641 @default.
- W3184186616 cites W1978072154 @default.
- W3184186616 cites W1983609229 @default.
- W3184186616 cites W2001457226 @default.
- W3184186616 cites W2005588714 @default.
- W3184186616 cites W2008632158 @default.
- W3184186616 cites W2014677321 @default.
- W3184186616 cites W2022884475 @default.
- W3184186616 cites W2023402149 @default.
- W3184186616 cites W2031050244 @default.
- W3184186616 cites W2034641256 @default.
- W3184186616 cites W2035321696 @default.
- W3184186616 cites W2048878532 @default.
- W3184186616 cites W2049772246 @default.
- W3184186616 cites W2050412495 @default.
- W3184186616 cites W2050723217 @default.
- W3184186616 cites W2055536181 @default.
- W3184186616 cites W2060833045 @default.
- W3184186616 cites W2062481845 @default.
- W3184186616 cites W2063760539 @default.
- W3184186616 cites W2068887701 @default.
- W3184186616 cites W2069766195 @default.
- W3184186616 cites W2070050178 @default.
- W3184186616 cites W2072677280 @default.
- W3184186616 cites W2089524021 @default.
- W3184186616 cites W2101117598 @default.
- W3184186616 cites W2102619694 @default.
- W3184186616 cites W2103441770 @default.
- W3184186616 cites W2113515610 @default.
- W3184186616 cites W2117131162 @default.
- W3184186616 cites W2122814930 @default.
- W3184186616 cites W2127600515 @default.
- W3184186616 cites W2130410032 @default.
- W3184186616 cites W2132596222 @default.
- W3184186616 cites W2133444149 @default.
- W3184186616 cites W2136623765 @default.
- W3184186616 cites W2140751228 @default.
- W3184186616 cites W2148383862 @default.
- W3184186616 cites W2152101492 @default.
- W3184186616 cites W2158217645 @default.
- W3184186616 cites W2158477352 @default.
- W3184186616 cites W2160488327 @default.
- W3184186616 cites W2170551349 @default.
- W3184186616 cites W2171808845 @default.
- W3184186616 cites W2180760460 @default.
- W3184186616 cites W2280729710 @default.
- W3184186616 cites W2284984697 @default.
- W3184186616 cites W2295446298 @default.
- W3184186616 cites W2342116893 @default.
- W3184186616 cites W2345356016 @default.
- W3184186616 cites W2410660174 @default.
- W3184186616 cites W2442856557 @default.
- W3184186616 cites W2536817740 @default.
- W3184186616 cites W2574687372 @default.
- W3184186616 cites W2589759270 @default.
- W3184186616 cites W2593741942 @default.
- W3184186616 cites W2625633983 @default.
- W3184186616 cites W2730255373 @default.
- W3184186616 cites W2743010525 @default.
- W3184186616 cites W2750200306 @default.
- W3184186616 cites W2762869502 @default.
- W3184186616 cites W2785758853 @default.
- W3184186616 cites W2791963264 @default.
- W3184186616 cites W2793127459 @default.
- W3184186616 cites W2795120956 @default.
- W3184186616 cites W2801685366 @default.
- W3184186616 cites W2809237949 @default.