Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184237051> ?p ?o ?g. }
- W3184237051 endingPage "4492" @default.
- W3184237051 startingPage "4492" @default.
- W3184237051 abstract "Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final product. The aim of this study was to investigate the influence of the drug load on printability and physical stability. The poor glass former naproxen (NAP) was hot-melt extruded with Kollidon® VA 64 at 10–30% w/w drug load. The extrudates (filaments) were characterised using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermogravimetric analysis (TGA). It was confirmed that an amorphous solid dispersion was formed. A temperature profile was developed based on the results from TGA, DSC, and DMA and temperatures used for 3D printing were selected from the profile. The 3D-printed tablets were characterised using DSC, X-ray computer microtomography (XµCT), and X-ray powder diffraction (XRPD). From the DSC and XRPD analysis, it was found that the drug in the 3D-printed tablets (20 and 30% NAP) was amorphous and remained amorphous after 23 weeks of storage (room temperature (RT), 37% relative humidity (RH)). This shows that adjusting the drug ratio can modulate the brittleness and improve printability without compromising the physical stability of the amorphous solid dispersion." @default.
- W3184237051 created "2021-08-02" @default.
- W3184237051 creator A5007376244 @default.
- W3184237051 creator A5009154408 @default.
- W3184237051 creator A5026103657 @default.
- W3184237051 creator A5055902694 @default.
- W3184237051 creator A5006472540 @default.
- W3184237051 date "2021-07-26" @default.
- W3184237051 modified "2023-10-13" @default.
- W3184237051 title "Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion" @default.
- W3184237051 cites W127232932 @default.
- W3184237051 cites W1505181639 @default.
- W3184237051 cites W154030718 @default.
- W3184237051 cites W186428516 @default.
- W3184237051 cites W1864794244 @default.
- W3184237051 cites W192787176 @default.
- W3184237051 cites W1969195434 @default.
- W3184237051 cites W2060427373 @default.
- W3184237051 cites W2074176923 @default.
- W3184237051 cites W2078307486 @default.
- W3184237051 cites W2118436621 @default.
- W3184237051 cites W2169796533 @default.
- W3184237051 cites W2253675932 @default.
- W3184237051 cites W2275521990 @default.
- W3184237051 cites W2299918954 @default.
- W3184237051 cites W2300453277 @default.
- W3184237051 cites W2306976198 @default.
- W3184237051 cites W2399031825 @default.
- W3184237051 cites W2510329588 @default.
- W3184237051 cites W2565380858 @default.
- W3184237051 cites W2580567426 @default.
- W3184237051 cites W2589280414 @default.
- W3184237051 cites W2592176131 @default.
- W3184237051 cites W2774056644 @default.
- W3184237051 cites W2783783408 @default.
- W3184237051 cites W2784237600 @default.
- W3184237051 cites W2790244053 @default.
- W3184237051 cites W2792921061 @default.
- W3184237051 cites W2794419052 @default.
- W3184237051 cites W2800695185 @default.
- W3184237051 cites W2804715583 @default.
- W3184237051 cites W2886154463 @default.
- W3184237051 cites W2898464641 @default.
- W3184237051 cites W2901600224 @default.
- W3184237051 cites W2908922764 @default.
- W3184237051 cites W2910482388 @default.
- W3184237051 cites W2956078602 @default.
- W3184237051 cites W3087784687 @default.
- W3184237051 cites W3095936246 @default.
- W3184237051 cites W3127609762 @default.
- W3184237051 cites W3135396554 @default.
- W3184237051 cites W3145467218 @default.
- W3184237051 cites W3157705021 @default.
- W3184237051 cites W607867075 @default.
- W3184237051 doi "https://doi.org/10.3390/molecules26154492" @default.
- W3184237051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8347219" @default.
- W3184237051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34361646" @default.
- W3184237051 hasPublicationYear "2021" @default.
- W3184237051 type Work @default.
- W3184237051 sameAs 3184237051 @default.
- W3184237051 citedByCount "7" @default.
- W3184237051 countsByYear W31842370512021 @default.
- W3184237051 countsByYear W31842370512022 @default.
- W3184237051 countsByYear W31842370512023 @default.
- W3184237051 crossrefType "journal-article" @default.
- W3184237051 hasAuthorship W3184237051A5006472540 @default.
- W3184237051 hasAuthorship W3184237051A5007376244 @default.
- W3184237051 hasAuthorship W3184237051A5009154408 @default.
- W3184237051 hasAuthorship W3184237051A5026103657 @default.
- W3184237051 hasAuthorship W3184237051A5055902694 @default.
- W3184237051 hasBestOaLocation W31842370511 @default.
- W3184237051 hasConcept C120665830 @default.
- W3184237051 hasConcept C121332964 @default.
- W3184237051 hasConcept C122865956 @default.
- W3184237051 hasConcept C127413603 @default.
- W3184237051 hasConcept C159985019 @default.
- W3184237051 hasConcept C177562468 @default.
- W3184237051 hasConcept C178790620 @default.
- W3184237051 hasConcept C185592680 @default.
- W3184237051 hasConcept C192562407 @default.
- W3184237051 hasConcept C2778958987 @default.
- W3184237051 hasConcept C39519442 @default.
- W3184237051 hasConcept C42360764 @default.
- W3184237051 hasConcept C521977710 @default.
- W3184237051 hasConcept C56052488 @default.
- W3184237051 hasConcept C60100273 @default.
- W3184237051 hasConcept C97355855 @default.
- W3184237051 hasConceptScore W3184237051C120665830 @default.
- W3184237051 hasConceptScore W3184237051C121332964 @default.
- W3184237051 hasConceptScore W3184237051C122865956 @default.
- W3184237051 hasConceptScore W3184237051C127413603 @default.
- W3184237051 hasConceptScore W3184237051C159985019 @default.
- W3184237051 hasConceptScore W3184237051C177562468 @default.
- W3184237051 hasConceptScore W3184237051C178790620 @default.
- W3184237051 hasConceptScore W3184237051C185592680 @default.
- W3184237051 hasConceptScore W3184237051C192562407 @default.
- W3184237051 hasConceptScore W3184237051C2778958987 @default.
- W3184237051 hasConceptScore W3184237051C39519442 @default.