FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184271844> ?p ?o ?g. }

• W3184271844 endingPage "110093" @default.
• W3184271844 startingPage "110093" @default.
• W3184271844 abstract "SOX17 has been shown to be involved in the transcriptional regulation of CXCR4, and CXCL12 functions by binding to its receptor CXCR4. Here, we explored the expression of SOX17 in neuroblastoma (NB), its mutual regulation with CXCL12, and its effects on cancer cell proliferation, migration and invasion. Five human NB cell lines and 15 pairs of NB and adjacent tissue specimens were used, to conduct RT-qPCR, immunohistochemistry, western blot, ELISA, CCK-8, colony formation, Edu, transwell, chromatin immunoprecipitation (ChIP), and dual-luciferase assays, to study the role of SOX17 in NB. SOX17 levels were reduced in both NB tissues and cell lines. SOX17 inhibited NB tumor growth, migration and invasion in vivo and suppressed NB cell proliferation, migration, and invasion in vitro. SOX17 knockdown or overexpression revealed a negative correlation between SOX17 and CXCL12/CXCR4 pathway activation. ChIP and dual-luciferase assays in NB cells demonstrated that SOX17 significantly inhibited CXCL12 gene and protein levels by binding to CXCL12 promoter regions. In vivo and in vitro experiments using the CXCR4 antagonist, AMD3100, demonstrated that cell proliferation, migration and invasion were significantly abrogated by AMD3100 in NB cells with SOX17 knocked down. Further, AMD3100 impaired growth of NB tumors with SOX17 knocked down in mice. Importantly, SOX17 bound to the CXCL12 promoter, which then activated downstream targets to regulate cell viability, proliferation, and migration. In conclusion, our data demonstrate that SOX17 expression is repressed in NB tissues and cells, and that SOX17 suppresses NB tumor formation and proliferation through inhibition of CXCL12/CXCR4 signaling." @default.
• W3184271844 created "2021-08-02" @default.
• W3184271844 creator A5006961808 @default.
• W3184271844 creator A5032538286 @default.
• W3184271844 creator A5049058744 @default.
• W3184271844 creator A5054367071 @default.
• W3184271844 creator A5057490932 @default.
• W3184271844 creator A5070324904 @default.
• W3184271844 date "2021-11-01" @default.
• W3184271844 modified "2023-10-16" @default.
• W3184271844 title "SOX17 inhibits proliferation and invasion of neuroblastoma through CXCL12/CXCR4 signaling axis" @default.
• W3184271844 cites W1877433127 @default.
• W3184271844 cites W1945249145 @default.
• W3184271844 cites W1964072224 @default.
• W3184271844 cites W1986986419 @default.
• W3184271844 cites W2006759411 @default.
• W3184271844 cites W2022156375 @default.
• W3184271844 cites W2040685567 @default.
• W3184271844 cites W2047283612 @default.
• W3184271844 cites W2067005958 @default.
• W3184271844 cites W2079181843 @default.
• W3184271844 cites W2081769332 @default.
• W3184271844 cites W2093977679 @default.
• W3184271844 cites W2103272211 @default.
• W3184271844 cites W2107277218 @default.
• W3184271844 cites W2125093701 @default.
• W3184271844 cites W2128870897 @default.
• W3184271844 cites W2140027591 @default.
• W3184271844 cites W2159415381 @default.
• W3184271844 cites W2218422691 @default.
• W3184271844 cites W2259137911 @default.
• W3184271844 cites W2341769195 @default.
• W3184271844 cites W2509683490 @default.
• W3184271844 cites W2530807664 @default.
• W3184271844 cites W2584822160 @default.
• W3184271844 cites W265896676 @default.
• W3184271844 cites W2705078637 @default.
• W3184271844 cites W2766330765 @default.
• W3184271844 cites W2779543239 @default.
• W3184271844 cites W2788562722 @default.
• W3184271844 cites W2810790606 @default.
• W3184271844 cites W2920848057 @default.
• W3184271844 cites W2969997614 @default.
• W3184271844 cites W2978417154 @default.
• W3184271844 cites W2979189299 @default.
• W3184271844 cites W3012050933 @default.
• W3184271844 cites W302273750 @default.
• W3184271844 cites W3034811254 @default.
• W3184271844 cites W4211147182 @default.
• W3184271844 doi "https://doi.org/10.1016/j.cellsig.2021.110093" @default.
• W3184271844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34302955" @default.
• W3184271844 hasPublicationYear "2021" @default.
• W3184271844 type Work @default.
• W3184271844 sameAs 3184271844 @default.
• W3184271844 citedByCount "2" @default.
• W3184271844 countsByYear W31842718442022 @default.
• W3184271844 crossrefType "journal-article" @default.
• W3184271844 hasAuthorship W3184271844A5006961808 @default.
• W3184271844 hasAuthorship W3184271844A5032538286 @default.
• W3184271844 hasAuthorship W3184271844A5049058744 @default.
• W3184271844 hasAuthorship W3184271844A5054367071 @default.
• W3184271844 hasAuthorship W3184271844A5057490932 @default.
• W3184271844 hasAuthorship W3184271844A5070324904 @default.
• W3184271844 hasConcept C101762097 @default.
• W3184271844 hasConcept C104317684 @default.
• W3184271844 hasConcept C129470790 @default.
• W3184271844 hasConcept C13373296 @default.
• W3184271844 hasConcept C134320426 @default.
• W3184271844 hasConcept C137738243 @default.
• W3184271844 hasConcept C150194340 @default.
• W3184271844 hasConcept C153911025 @default.
• W3184271844 hasConcept C170493617 @default.
• W3184271844 hasConcept C173396325 @default.
• W3184271844 hasConcept C2776715637 @default.
• W3184271844 hasConcept C502942594 @default.
• W3184271844 hasConcept C54355233 @default.
• W3184271844 hasConcept C55493867 @default.
• W3184271844 hasConcept C62112901 @default.
• W3184271844 hasConcept C62478195 @default.
• W3184271844 hasConcept C81885089 @default.
• W3184271844 hasConcept C86803240 @default.
• W3184271844 hasConcept C95444343 @default.
• W3184271844 hasConceptScore W3184271844C101762097 @default.
• W3184271844 hasConceptScore W3184271844C104317684 @default.
• W3184271844 hasConceptScore W3184271844C129470790 @default.
• W3184271844 hasConceptScore W3184271844C13373296 @default.
• W3184271844 hasConceptScore W3184271844C134320426 @default.
• W3184271844 hasConceptScore W3184271844C137738243 @default.
• W3184271844 hasConceptScore W3184271844C150194340 @default.
• W3184271844 hasConceptScore W3184271844C153911025 @default.
• W3184271844 hasConceptScore W3184271844C170493617 @default.
• W3184271844 hasConceptScore W3184271844C173396325 @default.
• W3184271844 hasConceptScore W3184271844C2776715637 @default.
• W3184271844 hasConceptScore W3184271844C502942594 @default.
• W3184271844 hasConceptScore W3184271844C54355233 @default.
• W3184271844 hasConceptScore W3184271844C55493867 @default.
• W3184271844 hasConceptScore W3184271844C62112901 @default.
• W3184271844 hasConceptScore W3184271844C62478195 @default.

• next