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• W3184306342 abstract "Rostro-caudal coordination of spinal motor output is essential for locomotion. Most spinal interneurons project axons longitudinally to govern locomotor output, yet their connectivity along this axis remains unclear. In this study, we use larval zebrafish to map synaptic outputs of a major inhibitory population, V1 (Eng1+) neurons, which are implicated in dual sensory and motor functions. We find that V1 neurons exhibit long axons extending rostrally and exclusively ipsilaterally for an average of 6 spinal segments; however, they do not connect uniformly with their post-synaptic targets along the entire length of their axon. Locally, V1 neurons inhibit motor neurons (both fast and slow) and other premotor targets, including V2a, V2b, and commissural premotor neurons. In contrast, V1 neurons make robust long-range inhibitory contacts onto a dorsal horn sensory population, the commissural primary ascending neurons (CoPAs). In a computational model of the ipsilateral spinal network, we show that this pattern of short-range V1 inhibition to motor and premotor neurons underlies burst termination, which is critical for coordinated rostro-caudal propagation of the locomotor wave. We conclude that spinal network architecture in the longitudinal axis can vary dramatically, with differentially targeted local and distal connections, yielding important consequences for function." @default.
• W3184306342 created "2021-08-02" @default.
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• W3184306342 date "2021-09-01" @default.
• W3184306342 modified "2023-09-23" @default.
• W3184306342 title "Spinal V1 neurons inhibit motor targets locally and sensory targets distally" @default.
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• W3184306342 doi "https://doi.org/10.1016/j.cub.2021.06.053" @default.
• W3184306342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8440420" @default.
• W3184306342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34289387" @default.
• W3184306342 hasPublicationYear "2021" @default.
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