Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184325475> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3184325475 endingPage "S255" @default.
- W3184325475 startingPage "S255" @default.
- W3184325475 abstract "Over the past decade, immunotherapeutic strategies that target immune-checkpoint proteins programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1), have transformed the treatment paradigm across varied types of cancer, including non-small cell lung cancer (NSCLC). Immune-checkpoint inhibitors (ICIs) have resulted in durable response and long-term survival in a subsets of patients with metastatic NSCLC. Unfortunately, only a small proportion of patients could benefit from ICI treatment. Therefore, it is crucial to identify biomarkers that can effectively predict the efficacy of ICIs. Circulating tumor DNA (ctDNA), due to its minimally invasive nature and tumor cell-derived genomic landscape, has shown a promising role in the management of patients receiving ICI treatment. Two important predictive biomarkers for ICIs, including tumor mutational burden (TMB) and microsatellite instability (MSI) have been demonstrated to be successfully assessed by analyzing ctDNA. Furthermore, quantitative ctDNA assessment before or during treatment is associated with tumor response in patients treated with ICIs. Dynamic monitoring ctDNA is also helpful to distinguish pseudoprogression from true progression during ICI treatment. Other applications of ctDNA in cancer immunotherapy are also currently being investigated, including detection of minimal residual disease, early detection of resistance to immunotherapy, tracking neoantigens by personalized ctDNA, epigenetics and transcriptomics analysis using ctDNA. In the future, integrating pre-treatment and on-treatment ctDNA and other immune biomarkers will be helpful for personalized immunotherapy." @default.
- W3184325475 created "2021-08-02" @default.
- W3184325475 creator A5006820907 @default.
- W3184325475 date "2021-07-01" @default.
- W3184325475 modified "2023-09-25" @default.
- W3184325475 title "SY10-1 The emerging role of cell-free DNA as a biomarker for cancer immunotherapy" @default.
- W3184325475 doi "https://doi.org/10.1016/j.annonc.2021.05.438" @default.
- W3184325475 hasPublicationYear "2021" @default.
- W3184325475 type Work @default.
- W3184325475 sameAs 3184325475 @default.
- W3184325475 citedByCount "0" @default.
- W3184325475 crossrefType "journal-article" @default.
- W3184325475 hasAuthorship W3184325475A5006820907 @default.
- W3184325475 hasBestOaLocation W31843254751 @default.
- W3184325475 hasConcept C104317684 @default.
- W3184325475 hasConcept C121608353 @default.
- W3184325475 hasConcept C126322002 @default.
- W3184325475 hasConcept C143998085 @default.
- W3184325475 hasConcept C180754005 @default.
- W3184325475 hasConcept C2776256026 @default.
- W3184325475 hasConcept C2777701055 @default.
- W3184325475 hasConcept C2779767149 @default.
- W3184325475 hasConcept C2780851360 @default.
- W3184325475 hasConcept C2781197716 @default.
- W3184325475 hasConcept C32220436 @default.
- W3184325475 hasConcept C502942594 @default.
- W3184325475 hasConcept C55493867 @default.
- W3184325475 hasConcept C60644358 @default.
- W3184325475 hasConcept C61320498 @default.
- W3184325475 hasConcept C71924100 @default.
- W3184325475 hasConcept C86803240 @default.
- W3184325475 hasConceptScore W3184325475C104317684 @default.
- W3184325475 hasConceptScore W3184325475C121608353 @default.
- W3184325475 hasConceptScore W3184325475C126322002 @default.
- W3184325475 hasConceptScore W3184325475C143998085 @default.
- W3184325475 hasConceptScore W3184325475C180754005 @default.
- W3184325475 hasConceptScore W3184325475C2776256026 @default.
- W3184325475 hasConceptScore W3184325475C2777701055 @default.
- W3184325475 hasConceptScore W3184325475C2779767149 @default.
- W3184325475 hasConceptScore W3184325475C2780851360 @default.
- W3184325475 hasConceptScore W3184325475C2781197716 @default.
- W3184325475 hasConceptScore W3184325475C32220436 @default.
- W3184325475 hasConceptScore W3184325475C502942594 @default.
- W3184325475 hasConceptScore W3184325475C55493867 @default.
- W3184325475 hasConceptScore W3184325475C60644358 @default.
- W3184325475 hasConceptScore W3184325475C61320498 @default.
- W3184325475 hasConceptScore W3184325475C71924100 @default.
- W3184325475 hasConceptScore W3184325475C86803240 @default.
- W3184325475 hasLocation W31843254751 @default.
- W3184325475 hasOpenAccess W3184325475 @default.
- W3184325475 hasPrimaryLocation W31843254751 @default.
- W3184325475 hasRelatedWork W1482345510 @default.
- W3184325475 hasRelatedWork W2009226744 @default.
- W3184325475 hasRelatedWork W2937519691 @default.
- W3184325475 hasRelatedWork W3171615116 @default.
- W3184325475 hasRelatedWork W3184046266 @default.
- W3184325475 hasRelatedWork W3217115064 @default.
- W3184325475 hasRelatedWork W4206284710 @default.
- W3184325475 hasRelatedWork W4223515873 @default.
- W3184325475 hasRelatedWork W4321446192 @default.
- W3184325475 hasRelatedWork W4365454315 @default.
- W3184325475 hasVolume "32" @default.
- W3184325475 isParatext "false" @default.
- W3184325475 isRetracted "false" @default.
- W3184325475 magId "3184325475" @default.
- W3184325475 workType "article" @default.