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- W3184336161 endingPage "112174" @default.
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- W3184336161 abstract "The aim of the present study was the loading of β-cyclodextrin/vitamin E (βCD/VitE) inclusion complex in liposomes (LPs) and coating of this nanocarrier with sodium caseinate (SC). The formation of βCD/VitE inclusion complex was approved by Fourier transforms infrared (FT-IR) spectroscopy. Three concentrations of SC (2, 4, and 6 mg/mL) were used for the coating of LPs. By considering particle size, zeta potential, and morphology, the 6 mg/mL concentration of SC was selected as the optimum concentration. The zeta potential and particle size of the coated complex-loaded LPs were +17.90 ± 0.80 mV and 173.9 ± 42.4 nm, respectively. The transmission electron microscopy of the coated complex-loaded LPs showed a spherical and core-shell structure. Additionally, the encapsulation efficiency of VitE in the LPs as the form of βCD/VitE inclusion complex was 83.8 ± 3.7%. The formation of hydrogen-bonding interactions among complex, LPs, and SC was confirmed by FT-IR spectroscopy. The coating of LPs with SC significantly improved their thermal stability. Moreover, the coated LPs exhibited a better-sustained release profile than the uncoated LPs in the simulated gastrointestinal condition. In conclusion, the developed nanocarrier has promising advantages and potential applications in the nutraceutical and medical fields. • The βCD/VitE inclusion complex was loaded in nanoliposomes (NLPs). • The βCD/VitE loaded NLPs were successfully coated with sodium caseinate (SC). • The coated NLPs showed improved thermal stability and nano particle size. • The optimized coated liposome sample showed spherical and core-shell structure. • Coating of liposomes with SC provided controlled release under in vitro condition." @default.
- W3184336161 created "2021-08-02" @default.
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- W3184336161 date "2021-11-01" @default.
- W3184336161 modified "2023-09-29" @default.
- W3184336161 title "Sodium caseinate-coated and β-cyclodextrin/vitamin E inclusion complex-loaded nanoliposomes: A novel stabilized nanocarrier" @default.
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- W3184336161 doi "https://doi.org/10.1016/j.lwt.2021.112174" @default.
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