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- W3184358974 endingPage "1636" @default.
- W3184358974 startingPage "1625" @default.
- W3184358974 abstract "The capacity for neurogenesis in the adult mammalian brain is extremely limited and highly restricted to a few regions, which greatly hampers neuronal regeneration and functional restoration after neuronal loss caused by injury or disease. Meanwhile, transplantation of exogenous neuronal stem cells into the brain encounters several serious issues including immune rejection and the risk of tumorigenesis. Recent discoveries of direct reprogramming of endogenous glial cells into functional neurons have provided new opportunities for adult neuro-regeneration. Here, we extensively review the experimental findings of the direct conversion of glial cells to neurons in vitro and in vivo and discuss the remaining issues and challenges related to the glial subtypes and the specificity and efficiency of direct cell-reprograming, as well as the influence of the microenvironment. Although in situ glial cell reprogramming offers great potential for neuronal repair in the injured or diseased brain, it still needs a large amount of research to pave the way to therapeutic application." @default.
- W3184358974 created "2021-08-02" @default.
- W3184358974 creator A5011611391 @default.
- W3184358974 creator A5080321548 @default.
- W3184358974 creator A5086866538 @default.
- W3184358974 date "2021-07-20" @default.
- W3184358974 modified "2023-10-13" @default.
- W3184358974 title "Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise" @default.
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- W3184358974 doi "https://doi.org/10.1007/s12264-021-00751-3" @default.
- W3184358974 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8566647" @default.
- W3184358974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34283396" @default.
- W3184358974 hasPublicationYear "2021" @default.
- W3184358974 type Work @default.