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• W3184377802 endingPage "131642" @default.
• W3184377802 startingPage "131642" @default.
• W3184377802 abstract "Neonicotinoids are replacement insecticides increasingly used for organophosphates, methylcarbamates, and pyrethroids. Experimental evidence suggests neonicotinoids may affect glucose metabolism and insulin secretion through pancreatic β cell dysfunction, oxidative stress, and inflammation. However, no epidemiologic study has investigated neonicotinoids as potential diabetogens. We examined associations between neonicotinoids with insulin and glucose homeostasis parameters among 1381 non-diabetic adults in the National Health and Nutrition Examination Survey (2015–2016). Urinary concentrations of acetamiprid, clothianidin, imidacloprid, N-desmethyl-acetamiprid, and 5-hydroxy-imidacloprid were quantified. Fasting plasma glucose, insulin, and hemoglobin A1c (HbA1c) were assessed. Insulin resistance was defined as a homeostatic model assessment of insulin resistance ≥2.5. We used weighted linear and logistic regression to estimate associations between detectable neonicotinoids with insulin and glucose homeostasis parameters compared to non-detectable neonicotinoid concentrations. Weighted detection frequencies for imidacloprid, 5-hydroxy-imidacloprid, and N-desmethyl-acetamiprid were 4.4 %, 21.5 %, and 32.8 %, respectively. Detectable imidacloprid (β = −4.7 μIU/mL, 95 % confidence interval [CI] -8.5, −0.8) and 5-hydroxy-imidacloprid (β = −2.4 μIU/mL, 95 % CI -4.6, −0.2) were associated with lower fasting plasma insulin levels. Individuals with detectable 5-hydroxy-imidacloprid had lower odds of insulin resistance (odds ratio [OR] = 0.3, 95 % CI 0.2, 0.7). We observed evidence of sexually dimorphic associations between N-desmethyl-acetamiprid with glucose (pint = 0.079) and 5-hydroxy-imidacloprid with HbA1c (pint = 0.038), with patterns suggesting positive associations in males and negative associations in females. Associations between 5-hydroxy-imidacloprid and insulin were modified by body mass index (BMI) (pint = 0.013). We additionally observed age modified associations between 5-hydyroxy-imidacloprid and glucose (pint = 0.048). Results suggest neonicotinoids may be associated with insulin and glucose homeostasis indices and call for prospective studies to examine the metabolic impact of these replacement insecticides in humans." @default.
• W3184377802 created "2021-08-02" @default.
• W3184377802 creator A5013602281 @default.
• W3184377802 creator A5037560489 @default.
• W3184377802 creator A5085850445 @default.
• W3184377802 date "2022-01-01" @default.
• W3184377802 modified "2023-10-12" @default.
• W3184377802 title "Associations of neonicotinoids with insulin and glucose homeostasis parameters in US adults: NHANES 2015–2016" @default.
• W3184377802 cites W1967207919 @default.
• W3184377802 cites W1969541824 @default.
• W3184377802 cites W1986355074 @default.
• W3184377802 cites W1992909979 @default.
• W3184377802 cites W1995924627 @default.
• W3184377802 cites W1996417359 @default.
• W3184377802 cites W1997861325 @default.
• W3184377802 cites W2000332894 @default.
• W3184377802 cites W2003937602 @default.
• W3184377802 cites W2012776064 @default.
• W3184377802 cites W2015594543 @default.
• W3184377802 cites W2019573279 @default.
• W3184377802 cites W2023754969 @default.
• W3184377802 cites W2029114428 @default.
• W3184377802 cites W2035745394 @default.
• W3184377802 cites W2038081709 @default.
• W3184377802 cites W2047522481 @default.
• W3184377802 cites W2058285305 @default.
• W3184377802 cites W2060804956 @default.
• W3184377802 cites W2061258953 @default.
• W3184377802 cites W2063914656 @default.
• W3184377802 cites W2081651087 @default.
• W3184377802 cites W2082130856 @default.
• W3184377802 cites W2087882379 @default.
• W3184377802 cites W2088684678 @default.
• W3184377802 cites W2099423538 @default.
• W3184377802 cites W2114416343 @default.
• W3184377802 cites W2129135681 @default.
• W3184377802 cites W2130263749 @default.
• W3184377802 cites W2137151882 @default.
• W3184377802 cites W2143799694 @default.
• W3184377802 cites W2147203478 @default.
• W3184377802 cites W2154954858 @default.
• W3184377802 cites W2160234571 @default.
• W3184377802 cites W2160447320 @default.
• W3184377802 cites W2164418602 @default.
• W3184377802 cites W2166954428 @default.
• W3184377802 cites W2190420240 @default.
• W3184377802 cites W2223906737 @default.
• W3184377802 cites W2267681011 @default.
• W3184377802 cites W2333776172 @default.
• W3184377802 cites W2428180603 @default.
• W3184377802 cites W2430259637 @default.
• W3184377802 cites W2471514741 @default.
• W3184377802 cites W2523516095 @default.
• W3184377802 cites W2548829003 @default.
• W3184377802 cites W2552586452 @default.
• W3184377802 cites W2576849769 @default.
• W3184377802 cites W2606787356 @default.
• W3184377802 cites W2607031541 @default.
• W3184377802 cites W2733950425 @default.
• W3184377802 cites W2734006339 @default.
• W3184377802 cites W2736180853 @default.
• W3184377802 cites W2746068532 @default.
• W3184377802 cites W2752158994 @default.
• W3184377802 cites W2766068715 @default.
• W3184377802 cites W2782485693 @default.
• W3184377802 cites W2790639628 @default.
• W3184377802 cites W2790995564 @default.
• W3184377802 cites W2794091944 @default.
• W3184377802 cites W2794153038 @default.
• W3184377802 cites W2800055937 @default.
• W3184377802 cites W2804813477 @default.
• W3184377802 cites W2810373483 @default.
• W3184377802 cites W2810879562 @default.
• W3184377802 cites W2885133466 @default.
• W3184377802 cites W2900212218 @default.
• W3184377802 cites W2902142233 @default.
• W3184377802 cites W2911461017 @default.
• W3184377802 cites W2922123106 @default.
• W3184377802 cites W2951884886 @default.
• W3184377802 cites W2965963190 @default.
• W3184377802 cites W2969924804 @default.
• W3184377802 cites W2970657072 @default.
• W3184377802 cites W2971095443 @default.
• W3184377802 cites W2991033511 @default.
• W3184377802 cites W2995643387 @default.
• W3184377802 cites W2996176050 @default.
• W3184377802 cites W2996349133 @default.
• W3184377802 cites W3000395588 @default.
• W3184377802 cites W3004870113 @default.
• W3184377802 cites W3023976359 @default.
• W3184377802 cites W3032926029 @default.
• W3184377802 cites W3087123676 @default.
• W3184377802 cites W3097685511 @default.
• W3184377802 doi "https://doi.org/10.1016/j.chemosphere.2021.131642" @default.
• W3184377802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8578312" @default.
• W3184377802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34351280" @default.
• W3184377802 hasPublicationYear "2022" @default.
• W3184377802 type Work @default.

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