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- W3184402834 abstract "Urinary tract infection (UTI) is one of the most common pediatricinfections and it may cause permanent kidney damage. Theβ-lactam antibiotics have traditionally been the main treatmentfor Enterobacteriaceae, nonetheless, the emergence of speciesproducing β- Lactamases has rendered this class of antibioticslargely ineffective. There are no published data on UTI etiologicalagents and antimicrobial resistance profile among children in Qatar.The aim of this study is to identify the most common ESBL speciesassociated with UTIs, to determine the phenotypic profiles ofantimicrobial resistant Enterobacteriaceae and to characterizeat the molecular level the genes encoding resistance in ESBLproducing Enterobacteriaceae among pediatric patients in Qatar.A total of 635 Enterobacteriaceae were isolated from 727 urinecultures, collected between February and June 2017 from children(0-15 years) diagnosed with UTI at Pediatric Emergency Center,Doha, Qatar. Most of the UTI were reported among 0-5 yearsold (73.6%) children. Initial screening with phoenix revealed 201(31.7 %) as Extended Spectrum β -Lactamases (ESBL) producingEnterobacteriaceae. The most predominant pathogen of thesewas E. coli 166 (83%), followed by K. pneumoniae 22 (11%).110 isolates were included for further analysis. ESBL resistancewas further confirmed by double disc synergy test and PCR. Thehighest resistance was encoded by bla CTX-M (59%) genes,primarily bla CTX-MG1 (89.2%), followed by bla CTX-MG9 (7.7%).37% of bacteria were harboring multiple bla genes (2 genes ormore). Analyzed samples were categorized into seven clonalclusters according to the presence and absence of seven genes.In conclusion, our data designate a high occurrence of CTX-MG1indicating a high dynamic transmit-ability in the community thatcould have a significant impact on public health, mostly throughhorizontal transmission in healthcare facilities. In addition, ourresults indicate an escalated problem of ESBL in pediatrics withUTI, which mandates the establishment of the antimicrobialstewardship program. Moreover, our findings revealed that the useof cephalosporins, gentamicin and trimethoprim/sulfamethoxazoleis compromised in Qatar among the pediatric population with UTI,leaving carbapenems and amikacin as the therapeutic option forsevere infections caused by ESBL producers. The negative impactof the extensive use of carpabenemes could lead to carbapenamaseresistant Enterobacteriaceae." @default.
- W3184402834 created "2021-08-02" @default.
- W3184402834 creator A5077530125 @default.
- W3184402834 date "2021-07-22" @default.
- W3184402834 modified "2023-09-23" @default.
- W3184402834 title "Prevalence and Molecular characteristics of ESBL associated with the pediatric population in Qatar" @default.
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