FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184499047> ?p ?o ?g. }

• W3184499047 abstract "The diversity offered by natural products has timelessly positioned them as a good source for novel therapeutics for the management of diverse medical conditions, including pain. This study evaluated hydro-ethanolic root bark extract of Ziziphus abyssinica (ZAE) as well as β-amyrin and polpunonic acid isolated from the plant for analgesic property. The study also investigated the mechanism responsible for this action in the extract. The antinociceptive potential of ZAE (30, 100, and 300 mg/kg, p. o .) was assessed using the tail-immersion test (TIT), acetic acid-induced writhing test (AAT), and formalin test (FT). The extract’s effect on acute and chronic musculoskeletal pain was also assessed by administering carrageenan unilaterally into the rat gastrocnemius muscles and measuring pain at 12 h and 10 days for acute and chronic pain respectively. The involvement of pro-inflammatory mediators (prostaglandin E 2 , bradykinin, TNF-α, and IL-1β) was assessed. The possible pathways mediating the observed analgesic effect of ZAE were further assessed using the antagonists: naloxone, glibenclamide, N G -L-nitro-arginine methyl ester (L-NAME), atropine, nifedipine, and yohimbine in the FT. Also the analgesic effect of two triterpenoid compounds, β-amyrin and polpunonic acid, previously isolated from the plant was assessed using the TIT. The anti-nociceptive activity of ZAE was demonstrated in the TIT by the significant ( p &lt; 0.05) increase in tail withdrawal threshold in ZAE-treated mice. ZAE also markedly reduced writhing and paw licking responses in both AAT and FT and significantly ( p &lt; 0.05) attenuated both acute and chronic musculoskeletal pain. ZAE also significantly reversed hyperalgesia induced by intraplantar injection of PGE 2 , bradykinin, TNF-α, and IL-1β. Furthermore, data revealed the involvement of opioidergic, ATP-sensitive K + channels and NO-cGMP pathways in the analgesic effect of ZAE. Both β-amyrin and polpunonic acid exhibited analgesic activity in the tail suspension test. Our study demonstrates ZAE as an important source of new therapeutic agents for pain management." @default.
• W3184499047 created "2021-08-02" @default.
• W3184499047 creator A5003585369 @default.
• W3184499047 creator A5011046812 @default.
• W3184499047 creator A5017906231 @default.
• W3184499047 creator A5020569507 @default.
• W3184499047 creator A5020657685 @default.
• W3184499047 creator A5045357335 @default.
• W3184499047 creator A5082922967 @default.
• W3184499047 creator A5085153026 @default.
• W3184499047 date "2021-07-20" @default.
• W3184499047 modified "2023-10-14" @default.
• W3184499047 title "Analgesic Effect of Ziziphus abyssinica Involves Inhibition of Inflammatory Mediators and Modulation of KATP Channels, Opioidergic and Nitrergic Pathways" @default.
• W3184499047 cites W1497969668 @default.
• W3184499047 cites W1773517648 @default.
• W3184499047 cites W1947883362 @default.
• W3184499047 cites W1963760749 @default.
• W3184499047 cites W1977704347 @default.
• W3184499047 cites W1999333086 @default.
• W3184499047 cites W2003504658 @default.
• W3184499047 cites W2009345240 @default.
• W3184499047 cites W2013425853 @default.
• W3184499047 cites W2018264662 @default.
• W3184499047 cites W2020949946 @default.
• W3184499047 cites W2023948668 @default.
• W3184499047 cites W2026195388 @default.
• W3184499047 cites W2028559363 @default.
• W3184499047 cites W2038693417 @default.
• W3184499047 cites W2043141738 @default.
• W3184499047 cites W2047800642 @default.
• W3184499047 cites W2055731811 @default.
• W3184499047 cites W2057494601 @default.
• W3184499047 cites W2068286850 @default.
• W3184499047 cites W2086305651 @default.
• W3184499047 cites W2097995606 @default.
• W3184499047 cites W2135582867 @default.
• W3184499047 cites W2227579106 @default.
• W3184499047 cites W2600236490 @default.
• W3184499047 cites W2610038523 @default.
• W3184499047 cites W2738387693 @default.
• W3184499047 cites W2791939032 @default.
• W3184499047 cites W2794528514 @default.
• W3184499047 cites W2796743485 @default.
• W3184499047 cites W2803846591 @default.
• W3184499047 cites W2902733917 @default.
• W3184499047 cites W2909160185 @default.
• W3184499047 cites W3006686178 @default.
• W3184499047 cites W3012020733 @default.
• W3184499047 cites W3043476716 @default.
• W3184499047 cites W3048904216 @default.
• W3184499047 cites W3168759183 @default.
• W3184499047 doi "https://doi.org/10.3389/fphar.2021.714722" @default.
• W3184499047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8329242" @default.
• W3184499047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34354595" @default.
• W3184499047 hasPublicationYear "2021" @default.
• W3184499047 type Work @default.
• W3184499047 sameAs 3184499047 @default.
• W3184499047 citedByCount "4" @default.
• W3184499047 countsByYear W31844990472022 @default.
• W3184499047 countsByYear W31844990472023 @default.
• W3184499047 crossrefType "journal-article" @default.
• W3184499047 hasAuthorship W3184499047A5003585369 @default.
• W3184499047 hasAuthorship W3184499047A5011046812 @default.
• W3184499047 hasAuthorship W3184499047A5017906231 @default.
• W3184499047 hasAuthorship W3184499047A5020569507 @default.
• W3184499047 hasAuthorship W3184499047A5020657685 @default.
• W3184499047 hasAuthorship W3184499047A5045357335 @default.
• W3184499047 hasAuthorship W3184499047A5082922967 @default.
• W3184499047 hasAuthorship W3184499047A5085153026 @default.
• W3184499047 hasBestOaLocation W31844990471 @default.
• W3184499047 hasConcept C134018914 @default.
• W3184499047 hasConcept C15490471 @default.
• W3184499047 hasConcept C170493617 @default.
• W3184499047 hasConcept C185592680 @default.
• W3184499047 hasConcept C2778750930 @default.
• W3184499047 hasConcept C2779004600 @default.
• W3184499047 hasConcept C2779591629 @default.
• W3184499047 hasConcept C2779768347 @default.
• W3184499047 hasConcept C2780723003 @default.
• W3184499047 hasConcept C2780820201 @default.
• W3184499047 hasConcept C2781063702 @default.
• W3184499047 hasConcept C2781227287 @default.
• W3184499047 hasConcept C55493867 @default.
• W3184499047 hasConcept C555293320 @default.
• W3184499047 hasConcept C71924100 @default.
• W3184499047 hasConcept C98274493 @default.
• W3184499047 hasConceptScore W3184499047C134018914 @default.
• W3184499047 hasConceptScore W3184499047C15490471 @default.
• W3184499047 hasConceptScore W3184499047C170493617 @default.
• W3184499047 hasConceptScore W3184499047C185592680 @default.
• W3184499047 hasConceptScore W3184499047C2778750930 @default.
• W3184499047 hasConceptScore W3184499047C2779004600 @default.
• W3184499047 hasConceptScore W3184499047C2779591629 @default.
• W3184499047 hasConceptScore W3184499047C2779768347 @default.
• W3184499047 hasConceptScore W3184499047C2780723003 @default.
• W3184499047 hasConceptScore W3184499047C2780820201 @default.
• W3184499047 hasConceptScore W3184499047C2781063702 @default.
• W3184499047 hasConceptScore W3184499047C2781227287 @default.
• W3184499047 hasConceptScore W3184499047C55493867 @default.
• W3184499047 hasConceptScore W3184499047C555293320 @default.

• next