FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184514836> ?p ?o ?g. }

• W3184514836 abstract "Abstract Background Meta-analyses typically consider multiple outcomes and report univariate effect sizes considered as independent. Multivariate meta-analysis (MVMA) incorporates outcome correlation and synthesises direct evidence and related outcome estimates within a single analysis. In a series of meta-analyses from the critically ill literature, the current study contrasts multiple univariate effect estimates and their precision with those derived from MVMA. Methods A previous meta-epidemiological study was used to identify meta-analyses with either one or two secondary outcomes providing sufficient detail to structure bivariate or tri-variate MVMA, with mortality as primary outcome. Analysis was performed using a random effects model for both odds ratio (OR) and risk ratio (RR); borrowing of strength (BoS) between multivariate outcome estimates was reported. Estimate comparisons, β coefficients, standard errors (SE) and confidence interval (CI) width, univariate versus multivariate, were performed using Lin’s concordance correlation coefficient (CCC). Results In bivariate meta-analyses, for OR ( n = 49) and RR ( n = 48), there was substantial concordance (≥ 0.69) between estimates; but this was less so for tri-variate meta-analyses for both OR ( n = 25; ≥ 0.38) and RR (≥ -0.10; n = 22). A variable change in the multivariate precision of primary mortality outcome estimates compared with univariate was present for both bivariate and tri-variate meta-analyses and for metrics. For second outcomes, precision tended to decrease and CI width increase for bivariate meta-analyses, but was variable in the tri-variate. For third outcomes, precision increased and CI width decreased. In bivariate meta-analyses, OR coefficient significance reversal, univariate versus MVMA, occurred once for mortality and 6 cases for second outcomes. RR coefficient significance reversal occurred in 4 cases; 2 were discordant with OR. For tri-variate OR meta-analyses reversal of coefficient estimate significance occurred in two cases for mortality, nine cases for second and 7 cases for third outcomes. In RR meta-analyses significance reversals occurred for mortality in 2 cases, 6 cases for second and 3 cases for third; there were 7 discordances with OR. BoS was greater in trivariate MVMAs compared with bivariate and for OR versus RR. Conclusions MVMA would appear to be the preferred solution to multiple univariate analyses; parameter significance changes may occur. Analytic metric appears to be a determinant." @default.
• W3184514836 created "2021-08-02" @default.
• W3184514836 creator A5083319191 @default.
• W3184514836 date "2021-07-18" @default.
• W3184514836 modified "2023-10-09" @default.
• W3184514836 title "Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study" @default.
• W3184514836 cites W123484885 @default.
• W3184514836 cites W1416071275 @default.
• W3184514836 cites W1509852289 @default.
• W3184514836 cites W1594588774 @default.
• W3184514836 cites W1643140812 @default.
• W3184514836 cites W1822346164 @default.
• W3184514836 cites W1968459043 @default.
• W3184514836 cites W1971917624 @default.
• W3184514836 cites W1986096796 @default.
• W3184514836 cites W1988469431 @default.
• W3184514836 cites W1990533469 @default.
• W3184514836 cites W1992325247 @default.
• W3184514836 cites W2000297407 @default.
• W3184514836 cites W2001318507 @default.
• W3184514836 cites W2002062153 @default.
• W3184514836 cites W2002304559 @default.
• W3184514836 cites W2013628062 @default.
• W3184514836 cites W2019271924 @default.
• W3184514836 cites W2020907841 @default.
• W3184514836 cites W2026417450 @default.
• W3184514836 cites W2037887534 @default.
• W3184514836 cites W204046373 @default.
• W3184514836 cites W2046205453 @default.
• W3184514836 cites W2046391772 @default.
• W3184514836 cites W2048104647 @default.
• W3184514836 cites W2048126670 @default.
• W3184514836 cites W2059130611 @default.
• W3184514836 cites W2060066311 @default.
• W3184514836 cites W2074365649 @default.
• W3184514836 cites W2079265442 @default.
• W3184514836 cites W2081383863 @default.
• W3184514836 cites W2089551539 @default.
• W3184514836 cites W2107328434 @default.
• W3184514836 cites W2110597233 @default.
• W3184514836 cites W2110746417 @default.
• W3184514836 cites W2111041307 @default.
• W3184514836 cites W2111143709 @default.
• W3184514836 cites W2113670582 @default.
• W3184514836 cites W2115345875 @default.
• W3184514836 cites W2117200377 @default.
• W3184514836 cites W2121221780 @default.
• W3184514836 cites W2121462621 @default.
• W3184514836 cites W2126602143 @default.
• W3184514836 cites W2128192830 @default.
• W3184514836 cites W2129567559 @default.
• W3184514836 cites W2132907803 @default.
• W3184514836 cites W2135277940 @default.
• W3184514836 cites W2142540473 @default.
• W3184514836 cites W2147527890 @default.
• W3184514836 cites W2148122976 @default.
• W3184514836 cites W2153097295 @default.
• W3184514836 cites W2153200786 @default.
• W3184514836 cites W2154230830 @default.
• W3184514836 cites W2157775267 @default.
• W3184514836 cites W2160596919 @default.
• W3184514836 cites W2162768498 @default.
• W3184514836 cites W2163958583 @default.
• W3184514836 cites W2164093802 @default.
• W3184514836 cites W2165762701 @default.
• W3184514836 cites W2221786516 @default.
• W3184514836 cites W2344358128 @default.
• W3184514836 cites W2408017125 @default.
• W3184514836 cites W2485177285 @default.
• W3184514836 cites W2516525774 @default.
• W3184514836 cites W2527786681 @default.
• W3184514836 cites W2568838772 @default.
• W3184514836 cites W2623612217 @default.
• W3184514836 cites W2744384905 @default.
• W3184514836 cites W2755833300 @default.
• W3184514836 cites W2765205364 @default.
• W3184514836 cites W2766156346 @default.
• W3184514836 cites W2767258537 @default.
• W3184514836 cites W2769528523 @default.
• W3184514836 cites W2769846159 @default.
• W3184514836 cites W2791077373 @default.
• W3184514836 cites W2795084033 @default.
• W3184514836 cites W2796324125 @default.
• W3184514836 cites W2810076098 @default.
• W3184514836 cites W2896642872 @default.
• W3184514836 cites W2920850085 @default.
• W3184514836 cites W2944486023 @default.
• W3184514836 cites W2948934992 @default.
• W3184514836 cites W2963890733 @default.
• W3184514836 cites W3046143956 @default.
• W3184514836 cites W3095445804 @default.
• W3184514836 cites W3158060210 @default.
• W3184514836 cites W4319053609 @default.
• W3184514836 doi "https://doi.org/10.1186/s12874-021-01336-4" @default.
• W3184514836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8286437" @default.
• W3184514836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34275460" @default.
• W3184514836 hasPublicationYear "2021" @default.
• W3184514836 type Work @default.
• W3184514836 sameAs 3184514836 @default.
• W3184514836 citedByCount "3" @default.

• next