Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184526705> ?p ?o ?g. }
- W3184526705 endingPage "730" @default.
- W3184526705 startingPage "730" @default.
- W3184526705 abstract "Vaccines constitute a strategy to reduce the burden of COVID-19, but the treatment of COVID-19 is still a challenge. The lack of approved drugs for severe COVID-19 makes repurposing or repositioning of approved drugs a relevant approach because it occurs at lower costs and in a shorter time. Most preclinical and clinical tests, including safety and pharmacokinetic profiles, were already performed. However, infective and inflammatory diseases such as COVID-19 are linked with hypoalbuminemia and downregulation of both phase I and phase II drug-metabolizing enzymes and transporters, which can occur in modifications of pharmacokinetics and consequentially of safety profiles. This appears to occur in a sex- and gender-specific way because of the sex and gender differences present in the immune system and inflammation, which, in turn, reflect on pharmacokinetic parameters. Therefore, to make better decisions about drug dosage regimens and to increases the safety profile in patients suffering from infective and inflammatory diseases such as COVID-19, it is urgently needed to study repurposing or repositioning drugs in men and in women paying attention to pharmacokinetics, especially for those drugs that are previously scarcely evaluated in women." @default.
- W3184526705 created "2021-08-02" @default.
- W3184526705 creator A5011147943 @default.
- W3184526705 creator A5019189552 @default.
- W3184526705 creator A5040561724 @default.
- W3184526705 date "2021-07-27" @default.
- W3184526705 modified "2023-10-16" @default.
- W3184526705 title "Just a Reflection: Does Drug Repurposing Perpetuate Sex-Gender Bias in the Safety Profile?" @default.
- W3184526705 cites W1152283192 @default.
- W3184526705 cites W1577647205 @default.
- W3184526705 cites W1618964886 @default.
- W3184526705 cites W1822107371 @default.
- W3184526705 cites W1915089052 @default.
- W3184526705 cites W1975212224 @default.
- W3184526705 cites W1983492903 @default.
- W3184526705 cites W1983592836 @default.
- W3184526705 cites W1984409435 @default.
- W3184526705 cites W1986693537 @default.
- W3184526705 cites W1994301907 @default.
- W3184526705 cites W2001632090 @default.
- W3184526705 cites W2008574207 @default.
- W3184526705 cites W2009482238 @default.
- W3184526705 cites W2009890917 @default.
- W3184526705 cites W2010408319 @default.
- W3184526705 cites W2010427019 @default.
- W3184526705 cites W2010993971 @default.
- W3184526705 cites W2015244046 @default.
- W3184526705 cites W2022817684 @default.
- W3184526705 cites W2027431314 @default.
- W3184526705 cites W2032309086 @default.
- W3184526705 cites W2035610264 @default.
- W3184526705 cites W2049609209 @default.
- W3184526705 cites W2056684332 @default.
- W3184526705 cites W2060443443 @default.
- W3184526705 cites W2062540327 @default.
- W3184526705 cites W2062941476 @default.
- W3184526705 cites W2064374681 @default.
- W3184526705 cites W2070652919 @default.
- W3184526705 cites W2081460129 @default.
- W3184526705 cites W2085852551 @default.
- W3184526705 cites W2109781017 @default.
- W3184526705 cites W2111956266 @default.
- W3184526705 cites W2113398090 @default.
- W3184526705 cites W2116635252 @default.
- W3184526705 cites W2116668728 @default.
- W3184526705 cites W2124796353 @default.
- W3184526705 cites W2139837686 @default.
- W3184526705 cites W2142686295 @default.
- W3184526705 cites W2151036184 @default.
- W3184526705 cites W2154291689 @default.
- W3184526705 cites W2155175040 @default.
- W3184526705 cites W2157249825 @default.
- W3184526705 cites W2159744597 @default.
- W3184526705 cites W2161427131 @default.
- W3184526705 cites W2165902578 @default.
- W3184526705 cites W2167719907 @default.
- W3184526705 cites W2170385855 @default.
- W3184526705 cites W2176809627 @default.
- W3184526705 cites W2321190985 @default.
- W3184526705 cites W2341818975 @default.
- W3184526705 cites W2401303216 @default.
- W3184526705 cites W2418641901 @default.
- W3184526705 cites W2529784452 @default.
- W3184526705 cites W2553059652 @default.
- W3184526705 cites W2568798765 @default.
- W3184526705 cites W2595413454 @default.
- W3184526705 cites W2754130545 @default.
- W3184526705 cites W2767252886 @default.
- W3184526705 cites W2797813432 @default.
- W3184526705 cites W2805532471 @default.
- W3184526705 cites W2806896602 @default.
- W3184526705 cites W2887377710 @default.
- W3184526705 cites W2896002881 @default.
- W3184526705 cites W2904382879 @default.
- W3184526705 cites W2904823773 @default.
- W3184526705 cites W2905310217 @default.
- W3184526705 cites W2905444998 @default.
- W3184526705 cites W2913761611 @default.
- W3184526705 cites W2935014396 @default.
- W3184526705 cites W2944611922 @default.
- W3184526705 cites W2946701623 @default.
- W3184526705 cites W2959534842 @default.
- W3184526705 cites W2976860067 @default.
- W3184526705 cites W2981369305 @default.
- W3184526705 cites W3004442407 @default.
- W3184526705 cites W3009912996 @default.
- W3184526705 cites W3010714477 @default.
- W3184526705 cites W3010848803 @default.
- W3184526705 cites W3013985628 @default.
- W3184526705 cites W3015549620 @default.
- W3184526705 cites W3016311875 @default.
- W3184526705 cites W3017154096 @default.
- W3184526705 cites W3017469460 @default.
- W3184526705 cites W3024845488 @default.
- W3184526705 cites W3025699671 @default.
- W3184526705 cites W3026626432 @default.
- W3184526705 cites W3031439233 @default.
- W3184526705 cites W3033773215 @default.