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- W3184681489 endingPage "214129" @default.
- W3184681489 startingPage "214129" @default.
- W3184681489 abstract "• Coordination and organometallic compounds as proteosynthesis inhibitors are summarized. • An overview on compounds for which mechanistic data was obtained is provided. • A preliminary relationship between structure of the complex and the mode of action has been established. • Attention to photocaged prodrugs is also paid. Translation is the most energy-consuming activity within cells. Due to metabolic demands and high proliferation, cancer cells require elevated rates of protein synthesis, thus providing a therapeutic window to selectively eliminate them. Among potential anticancer agents, metallodrugs have arisen as an important class of chemotherapeutics due to the variety of possible molecular architectures and multiple coordination and redox states these compounds can achieve. Inorganic medicinal drug discovery has experimented remarkable advances over the past decades with current metal-based representatives undergoing clinical trials for cancer disease. Herein, we summarize the status of research on metal compounds targeting proteosynthesis. This review starts with a brief overview on protein synthesis as an anticancer target that is followed by an introduction to translational control in cancer cells and the importance of this process for cancer therapy. Metal-based chemotherapeutic agents are classified according to the transition metal, accompanied by a discussion on their mode of action interfering with protein synthesis and recapitulating both preclinical and clinical data." @default.
- W3184681489 created "2021-08-02" @default.
- W3184681489 creator A5012497133 @default.
- W3184681489 creator A5014251604 @default.
- W3184681489 creator A5032675025 @default.
- W3184681489 creator A5033001588 @default.
- W3184681489 date "2021-11-01" @default.
- W3184681489 modified "2023-10-17" @default.
- W3184681489 title "Targeting translation: a promising strategy for anticancer metallodrugs" @default.
- W3184681489 cites W1880007162 @default.
- W3184681489 cites W1965694893 @default.
- W3184681489 cites W1969321578 @default.
- W3184681489 cites W1969473557 @default.
- W3184681489 cites W1972062053 @default.
- W3184681489 cites W1973180014 @default.
- W3184681489 cites W1976616802 @default.
- W3184681489 cites W1977603207 @default.
- W3184681489 cites W1978203330 @default.
- W3184681489 cites W1978505234 @default.
- W3184681489 cites W1980411311 @default.
- W3184681489 cites W1981206208 @default.
- W3184681489 cites W1981475784 @default.
- W3184681489 cites W1985233650 @default.
- W3184681489 cites W1987600206 @default.
- W3184681489 cites W1987604182 @default.
- W3184681489 cites W1988548899 @default.
- W3184681489 cites W1995595686 @default.
- W3184681489 cites W1997005119 @default.
- W3184681489 cites W1997716192 @default.
- W3184681489 cites W1998750778 @default.
- W3184681489 cites W2007954304 @default.
- W3184681489 cites W2008820074 @default.
- W3184681489 cites W2012108057 @default.
- W3184681489 cites W2012213924 @default.
- W3184681489 cites W2012492137 @default.
- W3184681489 cites W2015902113 @default.
- W3184681489 cites W2016107719 @default.
- W3184681489 cites W2017588171 @default.
- W3184681489 cites W2021973292 @default.
- W3184681489 cites W2022396615 @default.
- W3184681489 cites W2022495797 @default.
- W3184681489 cites W2025511820 @default.
- W3184681489 cites W2026875674 @default.
- W3184681489 cites W2037313242 @default.
- W3184681489 cites W2038291983 @default.
- W3184681489 cites W2039386747 @default.
- W3184681489 cites W2039810057 @default.
- W3184681489 cites W2046233677 @default.
- W3184681489 cites W2048764176 @default.
- W3184681489 cites W2050313963 @default.
- W3184681489 cites W2053409523 @default.
- W3184681489 cites W2053726603 @default.
- W3184681489 cites W2056899605 @default.
- W3184681489 cites W2059586921 @default.
- W3184681489 cites W2064656431 @default.
- W3184681489 cites W2065623366 @default.
- W3184681489 cites W2066916023 @default.
- W3184681489 cites W2073501290 @default.
- W3184681489 cites W2073769945 @default.
- W3184681489 cites W2073893672 @default.
- W3184681489 cites W2074025899 @default.
- W3184681489 cites W2075385784 @default.
- W3184681489 cites W2075614768 @default.
- W3184681489 cites W2079054756 @default.
- W3184681489 cites W2079351077 @default.
- W3184681489 cites W2089198803 @default.
- W3184681489 cites W2089341106 @default.
- W3184681489 cites W2091103707 @default.
- W3184681489 cites W2095122846 @default.
- W3184681489 cites W2106016335 @default.
- W3184681489 cites W2106404376 @default.
- W3184681489 cites W2108159110 @default.
- W3184681489 cites W2109675992 @default.
- W3184681489 cites W2111470815 @default.
- W3184681489 cites W2112253518 @default.
- W3184681489 cites W2112932498 @default.
- W3184681489 cites W2113254662 @default.
- W3184681489 cites W2119288883 @default.
- W3184681489 cites W2120736516 @default.
- W3184681489 cites W2127063807 @default.
- W3184681489 cites W2128327076 @default.
- W3184681489 cites W2131632095 @default.
- W3184681489 cites W2131651601 @default.
- W3184681489 cites W2132808237 @default.
- W3184681489 cites W2133984348 @default.
- W3184681489 cites W2136700368 @default.
- W3184681489 cites W2145573155 @default.
- W3184681489 cites W2146023637 @default.
- W3184681489 cites W2148406780 @default.
- W3184681489 cites W2155770546 @default.
- W3184681489 cites W2156615060 @default.
- W3184681489 cites W2162437451 @default.
- W3184681489 cites W2162695817 @default.
- W3184681489 cites W2166063624 @default.
- W3184681489 cites W2178254316 @default.
- W3184681489 cites W2179922138 @default.
- W3184681489 cites W2219121760 @default.
- W3184681489 cites W2252295447 @default.