FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184681921> ?p ?o ?g. }

• W3184681921 endingPage "1813" @default.
• W3184681921 startingPage "1813" @default.
• W3184681921 abstract "Paracoccidioidomycosis (PCM) is a systemic disease caused by Paracoccidioides spp. PCM is endemic in Latin America and most cases are registered in Brazil. This mycosis affects mainly the lungs, but can also spread to other tissues and organs, including the liver. Several approaches have been investigated to improve treatment effectiveness and protection against the disease. Extracellular vesicles (EVs) are good antigen delivery vehicles. The present work aims to investigate the use of EVs derived from Paracoccidioides brasiliensis as an immunization tool in a murine model of PCM. For this, male C57BL/6 were immunized with two doses of EVs plus adjuvant and then infected with P. brasiliensis. EV immunization induced IgM and IgG in vivo and cytokine production by splenocytes ex vivo. Further, immunization with EVs had a positive effect on mice infected with P. brasiliensis, as it induced activated T lymphocytes and NKT cell mobilization to the infected lungs, improved production of proinflammatory cytokines and the histopathological profile, and reduced fungal burden. Therefore, the present study shows a new role for P. brasiliensis EVs in the presence of adjuvant as modulators of the host immune system, suggesting their utility as immunizing agents." @default.
• W3184681921 created "2021-08-02" @default.
• W3184681921 creator A5016843289 @default.
• W3184681921 creator A5028182378 @default.
• W3184681921 creator A5029441169 @default.
• W3184681921 creator A5041929307 @default.
• W3184681921 creator A5043523399 @default.
• W3184681921 creator A5050320347 @default.
• W3184681921 creator A5074049686 @default.
• W3184681921 creator A5080845591 @default.
• W3184681921 date "2021-07-17" @default.
• W3184681921 modified "2023-10-01" @default.
• W3184681921 title "Protective Response in Experimental Paracoccidioidomycosis Elicited by Extracellular Vesicles Containing Antigens of Paracoccidioides brasiliensis" @default.
• W3184681921 cites W1801137129 @default.
• W3184681921 cites W1982520369 @default.
• W3184681921 cites W1993504250 @default.
• W3184681921 cites W2001555960 @default.
• W3184681921 cites W2016978376 @default.
• W3184681921 cites W2034923231 @default.
• W3184681921 cites W2040062946 @default.
• W3184681921 cites W2053197710 @default.
• W3184681921 cites W2061028372 @default.
• W3184681921 cites W2099117928 @default.
• W3184681921 cites W2103332846 @default.
• W3184681921 cites W2130591313 @default.
• W3184681921 cites W2136917827 @default.
• W3184681921 cites W2139289419 @default.
• W3184681921 cites W2140995106 @default.
• W3184681921 cites W2145553590 @default.
• W3184681921 cites W2170852633 @default.
• W3184681921 cites W2187315726 @default.
• W3184681921 cites W2328867652 @default.
• W3184681921 cites W2415020150 @default.
• W3184681921 cites W2537065834 @default.
• W3184681921 cites W2738307421 @default.
• W3184681921 cites W2757414377 @default.
• W3184681921 cites W2766049614 @default.
• W3184681921 cites W2803473238 @default.
• W3184681921 cites W2803724548 @default.
• W3184681921 cites W2805170482 @default.
• W3184681921 cites W2830145191 @default.
• W3184681921 cites W2885123963 @default.
• W3184681921 cites W2899820782 @default.
• W3184681921 cites W2920953721 @default.
• W3184681921 cites W2953262851 @default.
• W3184681921 cites W2965928004 @default.
• W3184681921 cites W4300936625 @default.
• W3184681921 doi "https://doi.org/10.3390/cells10071813" @default.
• W3184681921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8304155" @default.
• W3184681921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34359982" @default.
• W3184681921 hasPublicationYear "2021" @default.
• W3184681921 type Work @default.
• W3184681921 sameAs 3184681921 @default.
• W3184681921 citedByCount "6" @default.
• W3184681921 countsByYear W31846819212022 @default.
• W3184681921 countsByYear W31846819212023 @default.
• W3184681921 crossrefType "journal-article" @default.
• W3184681921 hasAuthorship W3184681921A5016843289 @default.
• W3184681921 hasAuthorship W3184681921A5028182378 @default.
• W3184681921 hasAuthorship W3184681921A5029441169 @default.
• W3184681921 hasAuthorship W3184681921A5041929307 @default.
• W3184681921 hasAuthorship W3184681921A5043523399 @default.
• W3184681921 hasAuthorship W3184681921A5050320347 @default.
• W3184681921 hasAuthorship W3184681921A5074049686 @default.
• W3184681921 hasAuthorship W3184681921A5080845591 @default.
• W3184681921 hasBestOaLocation W31846819211 @default.
• W3184681921 hasConcept C147483822 @default.
• W3184681921 hasConcept C150903083 @default.
• W3184681921 hasConcept C164027704 @default.
• W3184681921 hasConcept C189976730 @default.
• W3184681921 hasConcept C203014093 @default.
• W3184681921 hasConcept C207001950 @default.
• W3184681921 hasConcept C26291073 @default.
• W3184681921 hasConcept C2776914184 @default.
• W3184681921 hasConcept C2777681368 @default.
• W3184681921 hasConcept C2777863537 @default.
• W3184681921 hasConcept C2779108831 @default.
• W3184681921 hasConcept C2909986799 @default.
• W3184681921 hasConcept C86803240 @default.
• W3184681921 hasConcept C8891405 @default.
• W3184681921 hasConcept C89423630 @default.
• W3184681921 hasConceptScore W3184681921C147483822 @default.
• W3184681921 hasConceptScore W3184681921C150903083 @default.
• W3184681921 hasConceptScore W3184681921C164027704 @default.
• W3184681921 hasConceptScore W3184681921C189976730 @default.
• W3184681921 hasConceptScore W3184681921C203014093 @default.
• W3184681921 hasConceptScore W3184681921C207001950 @default.
• W3184681921 hasConceptScore W3184681921C26291073 @default.
• W3184681921 hasConceptScore W3184681921C2776914184 @default.
• W3184681921 hasConceptScore W3184681921C2777681368 @default.
• W3184681921 hasConceptScore W3184681921C2777863537 @default.
• W3184681921 hasConceptScore W3184681921C2779108831 @default.
• W3184681921 hasConceptScore W3184681921C2909986799 @default.
• W3184681921 hasConceptScore W3184681921C86803240 @default.
• W3184681921 hasConceptScore W3184681921C8891405 @default.
• W3184681921 hasConceptScore W3184681921C89423630 @default.
• W3184681921 hasIssue "7" @default.
• W3184681921 hasLocation W31846819211 @default.

• next