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- W3184776168 endingPage "728" @default.
- W3184776168 startingPage "728" @default.
- W3184776168 abstract "Assisted reproductive technologies (ART) are the treatment of choice for some infertile couples and even though these procedures are generally considered safe, children conceived by ART have shown higher reported risks of some perinatal and postnatal complications such as low birth weight, preterm birth, and childhood cancer. In addition, the frequency of some congenital imprinting disorders, like Beckwith-Wiedemann Syndrome and Silver-Russell Syndrome, is higher than expected in the general population after ART. Experimental evidence from animal studies suggests that ART can induce stress in the embryo and influence gene expression and DNA methylation. Human epigenome studies have generally revealed an enrichment of alterations in imprinted regions in children conceived by ART, but no global methylation alterations. ART procedures occur simultaneously with the establishment and maintenance of imprinting during embryonic development, so this may underlie the apparent sensitivity of imprinted regions to ART. The impact in adulthood of imprinting alterations that occurred during early embryonic development is still unclear, but some experimental evidence in mice showed higher risk to obesity and cardiovascular disease after the restriction of some imprinted genes in early embryonic development. This supports the hypothesis that imprinting alterations in early development might induce epigenetic programming of metabolism and affect long-term health. Given the growing use of ART, it is important to determine the impact of ART in genomic imprinting and long-term health." @default.
- W3184776168 created "2021-08-02" @default.
- W3184776168 creator A5050762970 @default.
- W3184776168 date "2021-07-22" @default.
- W3184776168 modified "2023-09-27" @default.
- W3184776168 title "Alteration of Genomic Imprinting after Assisted Reproductive Technologies and Long-Term Health" @default.
- W3184776168 cites W1533935872 @default.
- W3184776168 cites W1616346063 @default.
- W3184776168 cites W1821797507 @default.
- W3184776168 cites W1829006090 @default.
- W3184776168 cites W1954613254 @default.
- W3184776168 cites W1977085826 @default.
- W3184776168 cites W1977885037 @default.
- W3184776168 cites W1983634739 @default.
- W3184776168 cites W1984064393 @default.
- W3184776168 cites W1987948907 @default.
- W3184776168 cites W1996431759 @default.
- W3184776168 cites W1998745333 @default.
- W3184776168 cites W2000469450 @default.
- W3184776168 cites W2000530953 @default.
- W3184776168 cites W2001085821 @default.
- W3184776168 cites W2001405008 @default.
- W3184776168 cites W2002413208 @default.
- W3184776168 cites W2003049716 @default.
- W3184776168 cites W2003537844 @default.
- W3184776168 cites W2011576149 @default.
- W3184776168 cites W2016754212 @default.
- W3184776168 cites W2018531315 @default.
- W3184776168 cites W2019127737 @default.
- W3184776168 cites W2027930414 @default.
- W3184776168 cites W2035028401 @default.
- W3184776168 cites W2035877973 @default.
- W3184776168 cites W2036835673 @default.
- W3184776168 cites W2041689291 @default.
- W3184776168 cites W2047469234 @default.
- W3184776168 cites W2049590417 @default.
- W3184776168 cites W2055550188 @default.
- W3184776168 cites W2055859834 @default.
- W3184776168 cites W2060544523 @default.
- W3184776168 cites W2061229963 @default.
- W3184776168 cites W2063349418 @default.
- W3184776168 cites W2063432099 @default.
- W3184776168 cites W2067064741 @default.
- W3184776168 cites W2067181747 @default.
- W3184776168 cites W2067509268 @default.
- W3184776168 cites W2070830735 @default.
- W3184776168 cites W2086593674 @default.
- W3184776168 cites W2089536182 @default.
- W3184776168 cites W2096531574 @default.
- W3184776168 cites W2097089322 @default.
- W3184776168 cites W2097620122 @default.
- W3184776168 cites W2098103853 @default.
- W3184776168 cites W2099401496 @default.
- W3184776168 cites W2099560343 @default.
- W3184776168 cites W2100391663 @default.
- W3184776168 cites W2103246764 @default.
- W3184776168 cites W2104475671 @default.
- W3184776168 cites W2106423392 @default.
- W3184776168 cites W2107110775 @default.
- W3184776168 cites W2108146566 @default.
- W3184776168 cites W2111003908 @default.
- W3184776168 cites W2111400671 @default.
- W3184776168 cites W2113477073 @default.
- W3184776168 cites W2113690878 @default.
- W3184776168 cites W2114304416 @default.
- W3184776168 cites W2116531048 @default.
- W3184776168 cites W2118109154 @default.
- W3184776168 cites W2119502220 @default.
- W3184776168 cites W2120907497 @default.
- W3184776168 cites W2121230264 @default.
- W3184776168 cites W2121877920 @default.
- W3184776168 cites W2124182468 @default.
- W3184776168 cites W2124608202 @default.
- W3184776168 cites W2126503856 @default.
- W3184776168 cites W2132073332 @default.
- W3184776168 cites W2133217333 @default.
- W3184776168 cites W2133769516 @default.
- W3184776168 cites W2134098487 @default.
- W3184776168 cites W2134923363 @default.
- W3184776168 cites W2139267823 @default.
- W3184776168 cites W2140018835 @default.
- W3184776168 cites W2140691792 @default.
- W3184776168 cites W2143858605 @default.
- W3184776168 cites W2143915967 @default.
- W3184776168 cites W2144597014 @default.
- W3184776168 cites W2145226640 @default.
- W3184776168 cites W2145461152 @default.
- W3184776168 cites W2146242068 @default.
- W3184776168 cites W2147536097 @default.
- W3184776168 cites W2150408168 @default.
- W3184776168 cites W2152466864 @default.
- W3184776168 cites W2153182247 @default.
- W3184776168 cites W2153563181 @default.
- W3184776168 cites W2162534617 @default.
- W3184776168 cites W2163888890 @default.
- W3184776168 cites W2167020978 @default.
- W3184776168 cites W2190800365 @default.
- W3184776168 cites W2289008818 @default.