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- W3184797713 abstract "Abstract Radial glial (RG) cells are the neural stem cells of the developing neocortex. Apical RG (aRG) cells can delaminate to generate basal RG (bRG) cells, a cell type associated with human brain expansion. Here, we report that this delamination is regulated by the post-Golgi secretory pathway. Using in situ subcellular live imaging, we show that post-Golgi transport of RAB6+ vesicles occurs toward the minus ends of microtubules and depends on dynein. We demonstrate that the apical determinant Crumbs3 (CRB3) is also transported by dynein. Double knockout of RAB6A/A’ and RAB6B impairs apical localization of CRB3, and induces a retraction of aRG cell apical process, leading to delamination and ectopic division. These defects are phenocopied by knock-out of the dynein activator LIS1. Overall, our results identify a RAB6-dynein-LIS1 complex for Golgi to apical surface transport in aRG cells, and highlights the role of this pathway in the maintenance of neuroepithelial integrity." @default.
- W3184797713 created "2021-08-02" @default.
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- W3184797713 date "2021-07-24" @default.
- W3184797713 modified "2023-10-04" @default.
- W3184797713 title "Regulation of neuronal progenitor delamination by dynein-driven post-Golgi apical transport" @default.
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- W3184797713 doi "https://doi.org/10.1101/2021.07.23.453475" @default.
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