FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184876278> ?p ?o ?g. }

• W3184876278 endingPage "35" @default.
• W3184876278 startingPage "35" @default.
• W3184876278 abstract "Purpose: We examined structural and functional changes in the outer retina of a mouse model of glaucoma. We examined whether these changes are a secondary consequence of damage in the inner retina and whether neuroprotection of the inner retina also prevents outer retinal changes. Methods: We used an established microbead occlusion model of glaucoma whereby intraocular pressure (IOP) was elevated. Specific antibodies were used to label rod and cone bipolar cells (BCs), horizontal cells (HCs), and retinal ganglion cells (RGCs), as well as synaptic components in control and glaucomatous eyes, to assess structural damage and cell loss. ERG recordings were made to assess outer retina function. Results: We found structural and functional damage of BCs, including significant cell loss and dendritic/axonal remodeling of HCs, following IOP elevation. The first significant loss of both BCs occurred at 4 to 5 weeks after microbead injection. However, early changes in the dendritic structure of RGCs were observed at 3 weeks, but significant changes in the rod BC axon terminal structure were not seen until 4 weeks. We found that protection of inner retinal neurons in glaucomatous eyes by pharmacological blockade of gap junctions or genetic ablation of connexin 36 largely prevented outer retinal damage. Conclusions: Together, our results indicate that outer retinal impairments in glaucoma are a secondary sequalae of primary damage in the inner retina. The finding that neuroprotection of the inner retina can also prevent outer retinal damage has important implications with regard to the targets for effective neuroprotective therapy." @default.
• W3184876278 created "2021-08-02" @default.
• W3184876278 creator A5008758037 @default.
• W3184876278 creator A5026301377 @default.
• W3184876278 creator A5028247307 @default.
• W3184876278 creator A5051500568 @default.
• W3184876278 creator A5058052039 @default.
• W3184876278 date "2021-07-23" @default.
• W3184876278 modified "2023-09-24" @default.
• W3184876278 title "Neuroprotection of the Inner Retina Also Prevents Secondary Outer Retinal Pathology in a Mouse Model of Glaucoma" @default.
• W3184876278 cites W1545065700 @default.
• W3184876278 cites W1567036454 @default.
• W3184876278 cites W1964207930 @default.
• W3184876278 cites W1972799586 @default.
• W3184876278 cites W1976319292 @default.
• W3184876278 cites W1981471604 @default.
• W3184876278 cites W1981660619 @default.
• W3184876278 cites W1984401984 @default.
• W3184876278 cites W1986651040 @default.
• W3184876278 cites W1990976830 @default.
• W3184876278 cites W2005433264 @default.
• W3184876278 cites W2007545854 @default.
• W3184876278 cites W2009133239 @default.
• W3184876278 cites W2012441394 @default.
• W3184876278 cites W2013148589 @default.
• W3184876278 cites W2025988461 @default.
• W3184876278 cites W2034893938 @default.
• W3184876278 cites W2037084455 @default.
• W3184876278 cites W2040350916 @default.
• W3184876278 cites W2040957463 @default.
• W3184876278 cites W2049381025 @default.
• W3184876278 cites W2049917557 @default.
• W3184876278 cites W2049918942 @default.
• W3184876278 cites W2053286088 @default.
• W3184876278 cites W2057250698 @default.
• W3184876278 cites W2057774725 @default.
• W3184876278 cites W2061738739 @default.
• W3184876278 cites W2067149275 @default.
• W3184876278 cites W2069138077 @default.
• W3184876278 cites W2071335850 @default.
• W3184876278 cites W2071575828 @default.
• W3184876278 cites W2075822428 @default.
• W3184876278 cites W2078684091 @default.
• W3184876278 cites W2084340616 @default.
• W3184876278 cites W2091823156 @default.
• W3184876278 cites W2101365155 @default.
• W3184876278 cites W2106320041 @default.
• W3184876278 cites W2118720693 @default.
• W3184876278 cites W2123689976 @default.
• W3184876278 cites W2123999143 @default.
• W3184876278 cites W2134271696 @default.
• W3184876278 cites W2150899253 @default.
• W3184876278 cites W2156555987 @default.
• W3184876278 cites W2157988319 @default.
• W3184876278 cites W2161921948 @default.
• W3184876278 cites W2199100869 @default.
• W3184876278 cites W2252793112 @default.
• W3184876278 cites W2586457419 @default.
• W3184876278 cites W2590511362 @default.
• W3184876278 cites W2605876272 @default.
• W3184876278 cites W2624402324 @default.
• W3184876278 cites W2732996930 @default.
• W3184876278 cites W2736290846 @default.
• W3184876278 cites W2742047599 @default.
• W3184876278 cites W2763802658 @default.
• W3184876278 cites W2783679394 @default.
• W3184876278 cites W2802927435 @default.
• W3184876278 cites W2808483005 @default.
• W3184876278 cites W2983726740 @default.
• W3184876278 cites W3041609621 @default.
• W3184876278 cites W3049318948 @default.
• W3184876278 cites W4230825363 @default.
• W3184876278 cites W4236557375 @default.
• W3184876278 cites W4241774550 @default.
• W3184876278 cites W4242486577 @default.
• W3184876278 cites W4242713152 @default.
• W3184876278 cites W4244174637 @default.
• W3184876278 cites W4247502983 @default.
• W3184876278 cites W4248407091 @default.
• W3184876278 cites W4250726757 @default.
• W3184876278 doi "https://doi.org/10.1167/iovs.62.9.35" @default.
• W3184876278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8300060" @default.
• W3184876278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34297802" @default.
• W3184876278 hasPublicationYear "2021" @default.
• W3184876278 type Work @default.
• W3184876278 sameAs 3184876278 @default.
• W3184876278 citedByCount "4" @default.
• W3184876278 countsByYear W31848762782021 @default.
• W3184876278 countsByYear W31848762782022 @default.
• W3184876278 countsByYear W31848762782023 @default.
• W3184876278 crossrefType "journal-article" @default.
• W3184876278 hasAuthorship W3184876278A5008758037 @default.
• W3184876278 hasAuthorship W3184876278A5026301377 @default.
• W3184876278 hasAuthorship W3184876278A5028247307 @default.
• W3184876278 hasAuthorship W3184876278A5051500568 @default.
• W3184876278 hasAuthorship W3184876278A5058052039 @default.
• W3184876278 hasBestOaLocation W31848762781 @default.
• W3184876278 hasConcept C105702510 @default.

• next