Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184888051> ?p ?o ?g. }
- W3184888051 endingPage "105778" @default.
- W3184888051 startingPage "105778" @default.
- W3184888051 abstract "The plant Sophora flavescens Ait. has been used in the clinical management of colorectal cancer (CRC). Its constituent compounds, notably the alkaloids matrine, oxymatrine, and sophoridine, have received considerable research attention in experimental models of CRC in vivo and in vitro. This review found that extracts of S. flavescens and/or its constituent compounds have been reported to inhibit CRC cell proliferation by inducing cell-cycle arrest at the G1 phase, inducing apoptosis via the intrinsic pathway, interfering in cancer metabolism, inhibiting metastasis and angiogenesis, regulating senescence and telomeres, regulating the tumour microenvironment and down-regulating cancer-related inflammation. In addition, matrine and oxymatrine reversed multi-drug resistance and enhanced the effects of chemotherapies. These anti-cancer effects were associated with regulation of several cellular signalling pathways including: MAPK/ERK, PI3K/AKT/mTOR, p38MAPK, NF-κB, Hippo/LATS2, TGF-β/Smad, JAK/STAT3, RhoA/ROC, and Wnt/ β-catenin pathways. These multiple actions in CRC suggest the alkaloids of S. flavescens may be therapeutic candidates for CRC management. Nevertheless, there remains considerable scope for future research into its flavonoid constituents, the effects of combinations of compounds, and the interaction between these compounds and anti-cancer drugs. In addition, more research is needed to investigate likely drug ligand-receptor interactions for each of the bioactive compounds." @default.
- W3184888051 created "2021-08-02" @default.
- W3184888051 creator A5013783802 @default.
- W3184888051 creator A5021578577 @default.
- W3184888051 creator A5070653609 @default.
- W3184888051 creator A5073862289 @default.
- W3184888051 creator A5075466372 @default.
- W3184888051 creator A5090731378 @default.
- W3184888051 date "2021-09-01" @default.
- W3184888051 modified "2023-10-14" @default.
- W3184888051 title "Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer" @default.
- W3184888051 cites W1029708823 @default.
- W3184888051 cites W1538028541 @default.
- W3184888051 cites W1571559303 @default.
- W3184888051 cites W1585172157 @default.
- W3184888051 cites W1701539672 @default.
- W3184888051 cites W1884249196 @default.
- W3184888051 cites W1918480506 @default.
- W3184888051 cites W1966269514 @default.
- W3184888051 cites W1967255207 @default.
- W3184888051 cites W1972825083 @default.
- W3184888051 cites W1978213837 @default.
- W3184888051 cites W1981155770 @default.
- W3184888051 cites W1985484655 @default.
- W3184888051 cites W1985512433 @default.
- W3184888051 cites W1987588843 @default.
- W3184888051 cites W1991136374 @default.
- W3184888051 cites W1992514303 @default.
- W3184888051 cites W1992930337 @default.
- W3184888051 cites W1993407106 @default.
- W3184888051 cites W1993934102 @default.
- W3184888051 cites W1994947876 @default.
- W3184888051 cites W2005619367 @default.
- W3184888051 cites W2008757142 @default.
- W3184888051 cites W2009567773 @default.
- W3184888051 cites W2009925333 @default.
- W3184888051 cites W2016944524 @default.
- W3184888051 cites W2017154887 @default.
- W3184888051 cites W2020950228 @default.
- W3184888051 cites W2028504515 @default.
- W3184888051 cites W2029415253 @default.
- W3184888051 cites W2032347891 @default.
- W3184888051 cites W2039409357 @default.
- W3184888051 cites W2041916919 @default.
- W3184888051 cites W2045126600 @default.
- W3184888051 cites W2059287377 @default.
- W3184888051 cites W2066168802 @default.
- W3184888051 cites W2066906652 @default.
- W3184888051 cites W2075208972 @default.
- W3184888051 cites W2076583198 @default.
- W3184888051 cites W2081213990 @default.
- W3184888051 cites W2085653208 @default.
- W3184888051 cites W2085908746 @default.
- W3184888051 cites W2087952915 @default.
- W3184888051 cites W2088503467 @default.
- W3184888051 cites W2090085231 @default.
- W3184888051 cites W2096439168 @default.
- W3184888051 cites W2102942479 @default.
- W3184888051 cites W2103831817 @default.
- W3184888051 cites W2111253773 @default.
- W3184888051 cites W2121317746 @default.
- W3184888051 cites W2121619780 @default.
- W3184888051 cites W2121662032 @default.
- W3184888051 cites W2131666890 @default.
- W3184888051 cites W2133575920 @default.
- W3184888051 cites W2149142217 @default.
- W3184888051 cites W2154589460 @default.
- W3184888051 cites W2157334943 @default.
- W3184888051 cites W2158021558 @default.
- W3184888051 cites W2159454395 @default.
- W3184888051 cites W2163502188 @default.
- W3184888051 cites W2172133051 @default.
- W3184888051 cites W2187985754 @default.
- W3184888051 cites W2237260456 @default.
- W3184888051 cites W2321647501 @default.
- W3184888051 cites W2325008670 @default.
- W3184888051 cites W2361876374 @default.
- W3184888051 cites W2469004374 @default.
- W3184888051 cites W2500192509 @default.
- W3184888051 cites W2524307711 @default.
- W3184888051 cites W2539337557 @default.
- W3184888051 cites W2560728740 @default.
- W3184888051 cites W2561943186 @default.
- W3184888051 cites W2566478516 @default.
- W3184888051 cites W2610193187 @default.
- W3184888051 cites W2624883694 @default.
- W3184888051 cites W2633313719 @default.
- W3184888051 cites W2767432657 @default.
- W3184888051 cites W2782792613 @default.
- W3184888051 cites W2895682048 @default.
- W3184888051 cites W2899864830 @default.
- W3184888051 cites W2902263717 @default.
- W3184888051 cites W2910310212 @default.
- W3184888051 cites W2925722680 @default.
- W3184888051 cites W2945535500 @default.
- W3184888051 cites W2946363891 @default.
- W3184888051 cites W2946658635 @default.
- W3184888051 cites W2952417916 @default.