FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3184897000> ?p ?o ?g. }

• W3184897000 abstract "Abstract Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease with high variability of clinical symptoms. In most cases MS appears as a relapsing-remitting disease course that at a later stage transitions into irreversible progressive decline of neurologic function. The mechanisms underlying MS progression remain poorly understood. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. Here we demonstrate that mice that develop mild EAE after immunization with myelin oligodendrocyte glycoprotein 35-55 are prone to undergo clinical progression around 30 days after EAE induction. EAE progression was associated with reduction in CD11c + microglia and dispersed coalescent parenchymal infiltration. We found sex-dependent differences mediated by p38α signaling, a key regulator of inflammation. Selective reduction of CD11c + microglia in female mice with CD11c-promoter driven p38α knockout ( KO) correlated with increased rate of EAE progression. In protected animals, we found CD11c + microglia forming contacts with astrocyte processes at the glia limitans and immune cells retained within perivascular spaces. Together, our study provides evidence on the protective role of CD11c + microglia in controlling CNS immune cell parenchymal infiltration in autoimmune demyelination." @default.
• W3184897000 created "2021-08-02" @default.
• W3184897000 creator A5001959448 @default.
• W3184897000 creator A5008986838 @default.
• W3184897000 creator A5010315130 @default.
• W3184897000 creator A5030887664 @default.
• W3184897000 creator A5070712991 @default.
• W3184897000 creator A5072379424 @default.
• W3184897000 creator A5075667146 @default.
• W3184897000 creator A5082374858 @default.
• W3184897000 creator A5089793470 @default.
• W3184897000 creator A5091386381 @default.
• W3184897000 date "2018-08-20" @default.
• W3184897000 modified "2023-09-26" @default.
• W3184897000 title "Reduction in CD11c⁺microglia correlates with clinical progression in chronic experimental autoimmune demyelination" @default.
• W3184897000 cites W1533029876 @default.
• W3184897000 cites W1554991269 @default.
• W3184897000 cites W1559534070 @default.
• W3184897000 cites W1560481871 @default.
• W3184897000 cites W1607206274 @default.
• W3184897000 cites W1641259203 @default.
• W3184897000 cites W1978675331 @default.
• W3184897000 cites W1993804929 @default.
• W3184897000 cites W2001904531 @default.
• W3184897000 cites W2019926860 @default.
• W3184897000 cites W2020756145 @default.
• W3184897000 cites W2026218766 @default.
• W3184897000 cites W2048103330 @default.
• W3184897000 cites W2052741633 @default.
• W3184897000 cites W2053313675 @default.
• W3184897000 cites W2057682244 @default.
• W3184897000 cites W2058839898 @default.
• W3184897000 cites W2064539458 @default.
• W3184897000 cites W2069417375 @default.
• W3184897000 cites W2082190173 @default.
• W3184897000 cites W2090134990 @default.
• W3184897000 cites W2095411994 @default.
• W3184897000 cites W2099046115 @default.
• W3184897000 cites W2100438302 @default.
• W3184897000 cites W2107277218 @default.
• W3184897000 cites W2116041320 @default.
• W3184897000 cites W2131878205 @default.
• W3184897000 cites W2132924600 @default.
• W3184897000 cites W2136557471 @default.
• W3184897000 cites W2144110754 @default.
• W3184897000 cites W2144818921 @default.
• W3184897000 cites W2147904592 @default.
• W3184897000 cites W2152865207 @default.
• W3184897000 cites W2168028214 @default.
• W3184897000 cites W2169756180 @default.
• W3184897000 cites W2195259275 @default.
• W3184897000 cites W2196308323 @default.
• W3184897000 cites W2504925882 @default.
• W3184897000 cites W2622807556 @default.
• W3184897000 cites W2728530348 @default.
• W3184897000 cites W2737157719 @default.
• W3184897000 cites W2756092850 @default.
• W3184897000 cites W2788933778 @default.
• W3184897000 cites W2889831587 @default.
• W3184897000 cites W2913221496 @default.
• W3184897000 cites W2913625932 @default.
• W3184897000 cites W2952573669 @default.
• W3184897000 cites W2973980275 @default.
• W3184897000 cites W3102446918 @default.
• W3184897000 doi "https://doi.org/10.1101/396036" @default.
• W3184897000 hasPublicationYear "2018" @default.
• W3184897000 type Work @default.
• W3184897000 sameAs 3184897000 @default.
• W3184897000 citedByCount "0" @default.
• W3184897000 crossrefType "posted-content" @default.
• W3184897000 hasAuthorship W3184897000A5001959448 @default.
• W3184897000 hasAuthorship W3184897000A5008986838 @default.
• W3184897000 hasAuthorship W3184897000A5010315130 @default.
• W3184897000 hasAuthorship W3184897000A5030887664 @default.
• W3184897000 hasAuthorship W3184897000A5070712991 @default.
• W3184897000 hasAuthorship W3184897000A5072379424 @default.
• W3184897000 hasAuthorship W3184897000A5075667146 @default.
• W3184897000 hasAuthorship W3184897000A5082374858 @default.
• W3184897000 hasAuthorship W3184897000A5089793470 @default.
• W3184897000 hasAuthorship W3184897000A5091386381 @default.
• W3184897000 hasBestOaLocation W31848970001 @default.
• W3184897000 hasConcept C104317684 @default.
• W3184897000 hasConcept C127716648 @default.
• W3184897000 hasConcept C169760540 @default.
• W3184897000 hasConcept C203014093 @default.
• W3184897000 hasConcept C2776914184 @default.
• W3184897000 hasConcept C2777542381 @default.
• W3184897000 hasConcept C2778486448 @default.
• W3184897000 hasConcept C2778531937 @default.
• W3184897000 hasConcept C2778609137 @default.
• W3184897000 hasConcept C2779357208 @default.
• W3184897000 hasConcept C2779830541 @default.
• W3184897000 hasConcept C2779919695 @default.
• W3184897000 hasConcept C2780640218 @default.
• W3184897000 hasConcept C529278444 @default.
• W3184897000 hasConcept C55493867 @default.
• W3184897000 hasConcept C71924100 @default.
• W3184897000 hasConcept C86803240 @default.
• W3184897000 hasConcept C87753298 @default.
• W3184897000 hasConcept C8891405 @default.

• next